TYROBP promotes the spread of pancreatic cancer by causing M2 TAM polarization DOI
Dingwen Zhong, Yonghui Liao, Wenhui Chen

et al.

Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Background and Aim M2‐polarized tumor‐associated macrophages (M2 TAMs) are known to promote cancer progression, exosomes crucial mediators of communication within the tumor microenvironment (TME). However, specific role derived from M2 TAMs in pancreatic (PC) progression remains poorly understood. Tyrosine kinase binding protein (TYROBP, also as DAP12 for DNAX activating protein‐12) is a transmembrane signal transduction polypeptide that interacts with immune cell receptors, influencing cellular functions via pathways. TYROBP prominently found exosomes, facilitating its transfer PC cells suggesting potential pathogenesis. Methods This study initially confirmed presence exosomes. The impact on proliferation, apoptosis, migration, invasion was investigated. Special attention given TYROBP's influence metastasis underlying mechanisms, focusing particularly CD44/AKT/ERK signaling pathway. Results expression did not significantly affect proliferation or apoptosis but demonstrated notable inhibitory effect migration invasion, which mediated through Both vivo vitro experiments consistently showed enhanced metastasis. Conclusions elucidates plays direct promoting association polarization. Therefore, represents novel therapeutic target interventions aimed at combatting progression.

Language: Английский

TYROBP promotes the spread of pancreatic cancer by causing M2 TAM polarization DOI
Dingwen Zhong, Yonghui Liao, Wenhui Chen

et al.

Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Background and Aim M2‐polarized tumor‐associated macrophages (M2 TAMs) are known to promote cancer progression, exosomes crucial mediators of communication within the tumor microenvironment (TME). However, specific role derived from M2 TAMs in pancreatic (PC) progression remains poorly understood. Tyrosine kinase binding protein (TYROBP, also as DAP12 for DNAX activating protein‐12) is a transmembrane signal transduction polypeptide that interacts with immune cell receptors, influencing cellular functions via pathways. TYROBP prominently found exosomes, facilitating its transfer PC cells suggesting potential pathogenesis. Methods This study initially confirmed presence exosomes. The impact on proliferation, apoptosis, migration, invasion was investigated. Special attention given TYROBP's influence metastasis underlying mechanisms, focusing particularly CD44/AKT/ERK signaling pathway. Results expression did not significantly affect proliferation or apoptosis but demonstrated notable inhibitory effect migration invasion, which mediated through Both vivo vitro experiments consistently showed enhanced metastasis. Conclusions elucidates plays direct promoting association polarization. Therefore, represents novel therapeutic target interventions aimed at combatting progression.

Language: Английский

Citations

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