The Lancet Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Nature Medicine, Journal Year: 2024, Volume and Issue: 30(8), P. 2148 - 2164
Published: Aug. 1, 2024
Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex, multisystem disorder that can affect nearly every organ system be severely disabling. The cumulative global incidence long around 400 million individuals, which estimated to have an annual economic impact approximately $1 trillion-equivalent about 1% economy. Several mechanistic pathways are implicated in COVID, including viral persistence, immune dysregulation, mitochondrial dysfunction, complement endothelial inflammation microbiome dysbiosis. devastating impacts on individual lives and, due its complexity prevalence, also has major ramifications for systems economies, even threatening progress toward achieving Sustainable Development Goals. Addressing challenge requires ambitious coordinated-but so far absent-global research policy response strategy. In this interdisciplinary review, we provide synthesis state scientific evidence assess human health, systems, economy metrics, forward-looking roadmap.
Language: Английский
Citations
106
New England Journal of Medicine, Journal Year: 2024, Volume and Issue: 391(6), P. 515 - 525
Published: July 17, 2024
Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) can affect many organ systems. However, temporal changes during the disease 2019 (Covid-19) pandemic, including evolution SARS-CoV-2, may have affected risk and burden PASC. Whether PASC changed over course pandemic is unclear.
Language: Английский
Citations
84
Nature Medicine, Journal Year: 2024, Volume and Issue: 30(6), P. 1564 - 1573
Published: May 30, 2024
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes post-acute sequelae of disease 2019 (COVID-19) (PASC) in many organ systems. Risks these have been characterized up to years after infection, but longer-term follow-up is limited. Here we built a cohort 135,161 people with SARS-CoV-2 and 5,206,835 controls from the US Department Veterans Affairs who were followed for 3 estimate risks death PASC. Among non-hospitalized individuals, increased risk was no longer present first year incident PASC declined over still contributed 9.6 (95% confidence interval (CI): 0.4–18.7) disability-adjusted life (DALYs) per 1,000 persons third year. hospitalized remained significantly elevated (incidence rate ratio: 1.29 CI: 1.19–1.40)). Risk years, substantial residual year, leading 90.0 55.2–124.8) DALYs persons. Altogether, our findings show reduction time, burden mortality health loss remains among individuals.
Language: Английский
Citations
71
Cell, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
32
Nature Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Citations
15
Diagnostics, Journal Year: 2024, Volume and Issue: 14(6), P. 621 - 621
Published: March 14, 2024
While ground-glass opacity, consolidation, and fibrosis in the lungs are some of hallmarks acute SAR-CoV-2 infection, it remains unclear whether these pulmonary radiological findings would resolve after symptoms have subsided. We conducted a systematic review meta-analysis to evaluate chest computed tomography (CT) abnormalities stratified by COVID-19 disease severity multiple timepoints post-infection. PubMed/MEDLINE was searched for relevant articles until 23 May 2023. Studies with COVID-19-recovered patients follow-up CT at least 12 months post-infection were included. evaluated short-term (1–6 months) long-term (12–24 follow-ups (severe non-severe). A generalized linear mixed-effects model random effects used estimate event rates findings. total 2517 studies identified, which 43 met inclusion (N = 8858 patients). Fibrotic-like changes had highest rate (0.44 [0.3–0.59]) (0.38 [0.23–0.56]) follow-ups. meta-regression showed that over time decreased any abnormality (β −0.137, p 0.002), opacities −0.169, < 0.001), increased honeycombing 0.075, 0.03), did not change fibrotic-like changes, bronchiectasis, reticulation, interlobular septal thickening (p > 0.05 all). The severe subgroup significantly higher bronchiectasis 0.02), reticulation 0.001) when compared non-severe subgroup. In conclusion, significant remained up 2 years post-COVID-19, especially disease. Long-lasting post-SARS-CoV-2 infection signal future public health concern, necessitating extended monitoring, rehabilitation, survivor support, vaccination, ongoing research targeted therapies.
Language: Английский
Citations
14
The Lancet Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
1
Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(18)
Published: July 25, 2024
Epithelial barriers are programmed for defense and repair but also the site of long-term structural remodeling disease. In general, this paradigm features epithelial stem cells (ESCs) that called on to regenerate damaged tissues can be reprogrammed detrimental remodeling. Here we identified a Wfdc21-dependent monocyte-derived dendritic cell (moDC) population functioned as an early sentinel niche basal ESC reprogramming in mouse models injury after respiratory viral infection. Niche function depended moDC delivery ligand GPNMB receptor CD44 so properly timed antibody blockade or provided long-lasting correction broad disease phenotypes. These same control points worked directly human organoids. Together, findings identify mechanism explain modify what is otherwise stereotyped sometimes response injury.
Language: Английский
Citations
4
JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(12), P. e2450014 - e2450014
Published: Dec. 26, 2024
Importance COVID-19 infection has been associated with acute kidney injury. However, its possible association long-term function is not well understood. Objective To investigate whether decline accelerated after compared other respiratory tract infections. Design, Setting, and Participants This cohort study used linked data from the Stockholm Creatinine Measurements (SCREAM) Project between February 1, 2018, January 2022, in Stockholm, Sweden. All hospitalized nonhospitalized adults database at least 1 estimated glomerular filtration rate (eGFR) measurement 2 years prior to a positive test result or pneumonia diagnosis were selected. Statistical analyses conducted June 2023 October 2024. Exposure (including influenza). Main Outcomes Measures Mean annual change eGFR was calculated linear regression model. Results The comprised 134 565 individuals (74 819 females [55.6%]; median [IQR] age, 51 [37-64] years). consisted of 35 987 (19 359 [53.8%]; 71 [56-81] (IQR) baseline 94 (79-107) mL/min/1.73m for 79 (61-92) cohort. After adjustment covariates, both infections demonstrated decline, greater magnitude (3.4% [95% CI, 3.2%-3.5%] COVID-19; 2.3% 2.1%-2.5%] pneumonia). more severe among (5.4%; 95% 5.2%-5.6%) but remained similar those pneumonia. Conclusions Relevance found an function, particularly hospitalization, People who should receive closer monitoring ensure early optimized management chronic disease effectively prevent complications further decline.
Language: Английский
Citations
4
EMC - Tratado de Medicina, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Citations
0