Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection

The Lancet Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 101030 - 101030

Published: Feb. 1, 2025

Zika virus, a mosquito-transmitted orthoflavivirus, has become pathogen of global health concern ever since the virus caused an epidemic in Brazil 2015 associated with approximately 700 000 laboratory-confirmed cases congenital microcephaly. The subsequent spread 2016 resulted wide spectrum neurological, ophthalmological, and developmental abnormalities across Americas, Africa, Asia. In this context, non-human primate models have essential tools for research to understand pathogenesis brain injury perinatal complications developing testing medical countermeasures such as vaccines, diagnostics, therapeutics. Fetal been observed various species is influenced by factors strain, gestational age at inoculation, inoculation dose route. Miscarriages are also seen common outcomes first trimester infections. This Series paper reviews diverse currently used mitigate public effects future epidemics.

Language: Английский

Missed opportunities for equity: a crucial perspective on the Lancet's Zika virus research Series

The Lancet Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский