Pharmaceutical 3D Printing Technology Integrating Nanomaterials and Nanodevices for Precision Neurological Therapies DOI Creative Commons
Jurga Bernatonienė,

Mindaugas Plieskis,

Kęstutis Petrikonis

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 352 - 352

Published: March 9, 2025

Pharmaceutical 3D printing, combined with nanomaterials and nanodevices, presents a transformative approach to precision medicine for treating neurological diseases. This technology enables the creation of tailored dosage forms controlled release profiles, enhancing drug delivery across blood−brain barrier (BBB). The integration nanoparticles, such as poly lactic-co-glycolic acid (PLGA), chitosan, metallic nanomaterials, into 3D-printed scaffolds improves treatment efficacy by providing targeted prolonged release. Recent advances have demonstrated potential these systems in conditions like Parkinson’s disease, epilepsy, brain tumors. Moreover, printing allows multi-drug combinations personalized formulations that adapt individual patient needs. Novel approaches, including stimuli-responsive systems, on-demand dosing, theragnostics, provide new possibilities real-time monitoring disorders. Despite innovations, challenges remain terms scalability, regulatory approval, long-term safety. future perspectives this suggest its revolutionize treatments offering patient-specific therapies, improved penetration, enhanced outcomes. review discusses current state, applications, nanotechnology treatment, highlighting need further research overcome existing challenges.

Language: Английский

Delivery of drugs through the blood–brain barrier: need for trials DOI
William A. Banks, Michelle A. Erickson, Elizabeth M. Rhea

et al.

The Lancet Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Mechanisms of receptor-mediated transcytosis at the blood-brain barrier DOI Creative Commons
Habib Baghirov

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113595 - 113595

Published: March 6, 2025

In receptor-mediated transcytosis (RMT) of large therapeutics across the blood-brain barrier (BBB), construct - a macromolecule or larger carrier with therapeutic payload binds protein on brain capillary endothelial cells (BCEC), internalization and release into parenchyma. The construct's into, trafficking from, but also possible entrapment within BCEC are affected by its engineered properties whose optimization has helped derive insights transport mechanisms at BCEC. Furthermore, advances in multi-omics, as well large-scale screening directed evolution campaigns have identify new targets for RMT this perspective, I raise reflect some fundamental questions one can arrive comparing BBB-targeted constructs different target proteins. These concern underlying, transcytosis-promoting factors that constructs' appears to converge on, precise role proteins RMT, through which these may mediate trafficking, tentative criteria selection Based considerations propose several scenarios strategies interfere more efficient internalization, endosomal network toward abluminal membrane, from BCEC, both smaller macromolecules carriers.

Language: Английский

Citations

0
Pharmaceutical 3D Printing Technology Integrating Nanomaterials and Nanodevices for Precision Neurological Therapies DOI Creative Commons
Jurga Bernatonienė,

Mindaugas Plieskis,

Kęstutis Petrikonis

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 352 - 352

Published: March 9, 2025

Pharmaceutical 3D printing, combined with nanomaterials and nanodevices, presents a transformative approach to precision medicine for treating neurological diseases. This technology enables the creation of tailored dosage forms controlled release profiles, enhancing drug delivery across blood−brain barrier (BBB). The integration nanoparticles, such as poly lactic-co-glycolic acid (PLGA), chitosan, metallic nanomaterials, into 3D-printed scaffolds improves treatment efficacy by providing targeted prolonged release. Recent advances have demonstrated potential these systems in conditions like Parkinson’s disease, epilepsy, brain tumors. Moreover, printing allows multi-drug combinations personalized formulations that adapt individual patient needs. Novel approaches, including stimuli-responsive systems, on-demand dosing, theragnostics, provide new possibilities real-time monitoring disorders. Despite innovations, challenges remain terms scalability, regulatory approval, long-term safety. future perspectives this suggest its revolutionize treatments offering patient-specific therapies, improved penetration, enhanced outcomes. review discusses current state, applications, nanotechnology treatment, highlighting need further research overcome existing challenges.

Language: Английский

Citations

0