Obesity substantially impacts rheumatic and musculoskeletal diseases: time to act

Annals of the Rheumatic Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Obesity is a major health problem and risk factor for many chronic conditions, including rheumatic musculoskeletal diseases (RMDs). Around 7 in 10 adults with RMD live overweight or obesity. not only increases the of developing RMDs. It worsens disease activity, pain, fatigue; impairs treatment responses; thereby reduces quality life physical function. Further, obesity can amplify drive several comorbidities that are more prevalent RMDs hypertension, cardiovascular disease, type 2 diabetes, metabolic dysfunction-associated steatotic liver disease. Moreover, reciprocal arises since make it harder to be physically active maintain healthy weight, especially context an obesogenic environment. In this viewpoint, we review relevant evidence suggest confers distinctive, important challenges care daily living patients With advent highly effective drugs obesity, also highlight research needs robust clinical trials test efficacy effectiveness these therapies as part management inflammatory RMDs, primary agent adjuvant immune targeted therapeutics. Implementing such weight strategies should provide much-needed holistic approach our patients.

Language: Английский

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The cardiology community begins to embrace obesity as an important target for cardiovascular health

PLoS Medicine, Journal Year: 2025, Volume and Issue: 22(4), P. e1004578 - e1004578

Published: April 24, 2025

Naveed Sattar and Martin K Rutter discuss the contributory role of obesity in development progression cardiovascular disease, prospects for tackling epidemic.

Language: Английский

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Promising results but caution needed in GLP-1RA large scale epidemiology

Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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