Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science

The Lancet Psychiatry, Journal Year: 2020, Volume and Issue: 7(6), P. 547 - 560

Published: April 15, 2020

Language: Английский

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Depression

The Lancet, Journal Year: 2018, Volume and Issue: 392(10161), P. 2299 - 2312

Published: Nov. 1, 2018

Language: Английский

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The integrated motivational–volitional model of suicidal behaviour

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2018, Volume and Issue: 373(1754), P. 20170268 - 20170268

Published: July 16, 2018

Suicide is a major public health concern accounting for 800 000 deaths globally each year. Although there have been many advances in understanding suicide risk recent decades, our ability to predict no better now than it was 50 years ago. There are potential explanations this lack of progress, but the absence, until recently, comprehensive theoretical models that emergence suicidal ideation distinct from transition between and attempts/suicide key progress. The current article presents integrated motivational–volitional (IMV) model behaviour, one such model. We propose defeat entrapment drive group factors, entitled volitional moderators (VMs), govern behaviour. According IMV model, VMs include access means suicide, exposure capability (fearlessness about death increased physical pain tolerance), planning, impulsivity, mental imagery past In article, we describe origins premises underpinning empirical tests future research directions. This part theme issue ‘Evolutionary thanatology: impacts dead on living humans other animals'.

Language: Английский

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Anxiety disorders

The Lancet, Journal Year: 2021, Volume and Issue: 397(10277), P. 914 - 927

Published: Feb. 11, 2021

Language: Английский

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Reducing the global burden of depression: a Lancet–World Psychiatric Association Commission

The Lancet, Journal Year: 2018, Volume and Issue: 393(10189), P. e42 - e43

Published: Oct. 25, 2018

Language: Английский

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Global, regional and national burden of anxiety disorders from 1990 to 2019: results from the Global Burden of Disease Study 2019

Epidemiology and Psychiatric Sciences, Journal Year: 2021, Volume and Issue: 30

Published: Jan. 1, 2021

Abstract Aims Anxiety disorders are widespread across the world. A systematic understanding of disease burden, temporal trend and risk factors anxiety provides essential foundation for targeted public policies on mental health at national, regional, global levels. Methods The estimation in Global Burden Disease Study 2019 using review was conducted to describe incidence, prevalence disability-adjusted life years (DALYs) 204 countries regions from 1990 2019. We calculated estimated annual percentage change (EAPC) quantify trends burden by sex, region age over past 30 analysed impact epidemiological demographic changes disorders. Results Globally, 45.82 [95% uncertainty interval (UI): 37.14, 55.62] million incident cases disorders, 301.39 (95% UI: 252.63, 356.00) prevalent 28.68 19.86, 39.32) DALYs were Although overall age-standardised rate remained stable three decades, latest absolute number increased 50% 1990. observed huge disparities both changing country age. In 2019, 7.07% due attributable bullying victimisation, mainly among population aged 5–39 years, proportion almost all territories compared with Conclusion disorder is still most common illness world has a striking disease. Controlling potential factors, such as bullying, establishing effective knowledge dissemination diversifying intervention strategies adapted specific characteristics will reduce

Language: Английский

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Digital interventions for the treatment of depression: A meta-analytic review.

Psychological Bulletin, Journal Year: 2021, Volume and Issue: 147(8), P. 749 - 786

Published: Aug. 1, 2021

The high global prevalence of depression, together with the recent acceleration remote care owing to COVID-19 pandemic, has prompted increased interest in efficacy digital interventions for treatment depression.We provide a summary latest evidence base depression based on largest study sample date.A systematic literature search identified 83 studies (N = 15,530) that randomly allocated participants intervention versus an active or inactive control condition.Overall heterogeneity was very (I 2 84%).Using random-effects multilevel metaregression model, we found significant medium overall effect size compared all conditions (g .52).Subgroup analyses revealed differences between and different (WLC: g .70;attention: .36;TAU: .31),significantly higher sizes involved human therapeutic guidance .63)compared self-help .34),and significantly lower effectiveness trials .30)compared .59).We no difference outcomes smartphone-based apps computer-and Internet-based human-guided face-to-face psychotherapy although number both comparisons low.Findings from current meta-analysis variety populations.However, reported may be exaggerated because publication bias, compliance outside highly controlled settings remains challenge. Public Significance StatementThis demonstrates populations.Additionally, it highlights have valuable role play routine care, most notably when accompanied by guidance.However, major challenge, little more than 50% completing full average.

Language: Английский

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Toward clinical digital phenotyping: a timely opportunity to consider purpose, quality, and safety

npj Digital Medicine, Journal Year: 2019, Volume and Issue: 2(1)

Published: Sept. 6, 2019

The use of data generated passively by personal electronic devices, such as smartphones, to measure human function in health and disease has significant research interest. Particularly psychiatry, objective, continuous quantitation using patients' own devices may result clinically useful markers that can be used refine diagnostic processes, tailor treatment choices, improve condition monitoring for actionable outcomes, early signs relapse, develop new intervention models. If a principal goal digital phenotyping is clinical improvement, needs attend now factors will help or hinder future adoption. We identify four opportunities directed toward this goal: exploring intermediate outcomes underlying mechanisms; focusing on purposes are likely practice; anticipating quality safety barriers adoption; the potential personalized medicine arising from integration interventions. Clinical relevance also means explicitly addressing consumer needs, preferences, acceptability ultimate users There risk that, without considerations, benefits delayed not realized because approaches feasible application healthcare, evidence required support commissioning, developed. Practical steps accelerate agenda include further development technology platforms scalability equity, establishing shared repositories common standards, fostering multidisciplinary collaborations between stakeholders (including patients), computer scientists, researchers.

Language: Английский

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Effectiveness of digital psychological interventions for mental health problems in low-income and middle-income countries: a systematic review and meta-analysis

The Lancet Psychiatry, Journal Year: 2020, Volume and Issue: 7(10), P. 851 - 864

Published: Aug. 29, 2020

Language: Английский

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Effectiveness of CBT for children and adolescents with depression: A systematic review and meta-regression analysis

European Psychiatry, Journal Year: 2019, Volume and Issue: 57, P. 33 - 45

Published: Jan. 16, 2019

Cognitive-behavioral therapy (CBT) is first choice of treatment for depressive symptoms and disorders in adolescents, however improvements are necessary because overall efficacy low. Insights on CBT components contextual structural characteristics might increase the efficacy. The aim our approach to evaluate youth with depression investigate influence specific components, factors that could improve effects.A systematic review randomized controlled trials was conducted, searches were undertaken CINAHL, CENTRAL, EMBASE, MEDLINE/PubMed PsycINFO. Outcomes meta-analyzed confidence results assessed using GRADE-method. Meta-regression used pinpoint or other associated an in- decrease effects CBT.We included 31 4335 participants. Moderate-quality evidence found reducing at end follow-up, as indicated prevention resulted 63% less risk being depressed follow-up. containing a combination behavioral activation challenging thoughts component (as part cognitive restructuring) involvement caregiver(s) intervention better outcomes long term.There effective (subclinical) depression. Our analyses show when contains also involved. However, influential these three moderators should be further tested RCTs.

Language: Английский

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