Global scientific research landscape on binge drinking: a comprehensive bibliometric and visualization analysis of trends, collaborations, and future directions DOI Creative Commons
Sa’ed H. Zyoud

Substance Abuse Treatment Prevention and Policy, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 10, 2025

Binge drinking constitutes a significant public health concern. Defined as the consumption of five or more alcoholic beverages on single occasion, binge leads to acute cognitive and motor impairments is associated with multitude detrimental consequences. Therefore, aim this study was analyse globally published peer-reviewed literature drinking. A thorough search Scopus database conducted gather all relevant research. Keywords related were used locate wide range studies. Specific criteria subsequently applied narrow results, ensuring inclusion only most articles. This process yielded collection 2,763 research papers. Finally, software program called VOSviewer utilized visualize connections between these bibliometric analysis performed investigate trends in 1980 2024. The findings revealed increase publications (R²=0.916; p < 0.001), peak 2018 (191 articles). majority (89.65%, n = 2,477) articles, followed by review articles (4.74%, 131). Authors from 139 countries contributed binge-drinking research, USA (n 1,550; 56.1%) UK 216; 7.82%) leading volume publications. National Institute Alcohol Abuse Alcoholism 65; 2.35%) University North Carolina at Chapel Hill 63; 2.28%) emerged main institutional contributors. United States funding source, supporting 599 (21.68%), Institutes Health States, 544 (19.69%). In particular, post-2016 period witnessed shift themes toward mechanistic investigations alongside studies societal interventions, reflecting growing focus mitigating broader social impact first comprehensive Over past decade, has increased dramatically, led UK, Spain. Initially, focused cultural factors, shifted after 2016 animal models, shaping future directions strategies.

Language: Английский

Psychiatric comorbidities in alcohol use disorder DOI
Álvaro Castillo‐Carniglia, Katherine M. Keyes, Deborah S. Hasin

et al.

The Lancet Psychiatry, Journal Year: 2019, Volume and Issue: 6(12), P. 1068 - 1080

Published: Oct. 17, 2019

Language: Английский

Citations

321
Use of Medications for Alcohol Use Disorder in the US DOI Open Access
Beth Han, Christopher M. Jones,

Emily B. Einstein

et al.

JAMA Psychiatry, Journal Year: 2021, Volume and Issue: 78(8), P. 922 - 922

Published: June 16, 2021

Treatment rates for alcohol use disorder (AUD) are low 1 (eg, 7.6% in 2019 2 ).The US Food and Drug Administration has approved 4 evidence-based medications treating

Language: Английский

Citations

80
Alcohol use disorders and ADHD DOI
Mathias Luderer, Josep Antoni Ramos‐Quiroga, Stephen V. Faraone

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 128, P. 648 - 660

Published: July 12, 2021

Language: Английский

Citations

63
Diabetes and Mental Health DOI Creative Commons

David J. Robinson,

Kimberley Hanson,

Akshay Jain

et al.

Canadian Journal of Diabetes, Journal Year: 2023, Volume and Issue: 47(4), P. 308 - 344

Published: June 1, 2023

Diabetes mellitus is a disease that takes heavy toll on the lives of people who have received diagnosis. For those diagnosed with T1D, it major life stress (and can become medical emergency) often dominates focus individuals and their families. T2D be (often for first several years) asymptomatic or cause symptoms are relatively easy to ignore. Yet, minor metabolic aberrations develop into larger ones eventually affect most physiological systems lead characteristic end-stage complications threaten life, limb, vital functions.

Language: Английский

Citations

36
Biomarkers of moderate alcohol intake and alcoholic beverages: a systematic literature review DOI Creative Commons
Marta Trius‐Soler, Giulia Praticò,

Gözde Gürdeniz

et al.

Genes & Nutrition, Journal Year: 2023, Volume and Issue: 18(1)

Published: April 19, 2023

Abstract The predominant source of alcohol in the diet is alcoholic beverages, including beer, wine, spirits and liquors, sweet ciders. Self-reported intakes are likely to be influenced by measurement error, thus affecting accuracy precision currently established epidemiological associations between itself, beverage consumption, health or disease. Therefore, a more objective assessment intake would very valuable, which may through biomarkers food (BFIs). Several direct indirect have been proposed forensic clinical contexts assess recent longer-term intakes. Protocols for performing systematic reviews this field, as well assessing validity candidate BFIs, developed within Food Biomarker Alliance (FoodBAll) project. aim review list validate ethanol per se excluding markers abuse, but related common categories beverages. Validation biomarker(s) itself each was done according published guideline biomarker reviews. In conclusion, intake, e.g., ethyl glucuronide, sulfate, fatty acid esters, phosphatidyl ethanol, show considerable inter-individual response, especially at low moderate intakes, need further development improved validation, while BFIs beer wine highly promising help accurate assessments these specific

Language: Английский

Citations

25
Repurposing Semaglutide and Liraglutide for Alcohol Use Disorder DOI Creative Commons
Markku Lähteenvuo, Jari Tiihonen, Anssi Solismaa

et al.

JAMA Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Importance Preliminary studies suggest that glucagon-like peptide-1 receptor (GLP-1) agonists, used to treat type 2 diabetes and obesity, may decrease alcohol consumption. Objective To test whether the risk of hospitalization due use disorder (AUD) is decreased during GLP-1 agonists compared with periods nonuse for same individual. Design, Setting, Participants This cohort study was an observational conducted nationwide in Sweden using data from January 2006 December 2023. The population-based identified registers inpatient care, specialized outpatient sickness absence, disability pension. were all residents aged 16 64 years who had a diagnosis AUD. Exposures primary exposure individual (compared agonists), secondary medications indication Main Outcomes Measures outcome AUD analyzed Cox regression within-individual model. Secondary outcomes any substance (SUD)–related hospitalization, somatic suicide attempt. Results included 227 866 individuals AUD; 144 714 (63.5%) male 83 154 (36.5%) female, mean (SD) age 40.0 (15.7) years. Median (IQR) follow-up time 8.8 (4.0-13.3) A total 133 210 (58.5%) experienced hospitalization. Semaglutide (4321 users) associated lowest (AUD: adjusted hazard ratio [aHR], 0.64; 95% CI, 0.50-0.83; SUD: aHR, 0.68; 0.54-0.85) liraglutide (2509 second 0.72; 0.57-0.92; 0.78; 0.64-0.97) both SUD Use medication modestly (aHR, 0.98; 0.96-1.00). 0.68-0.90) 0.79; 0.69-0.91) also hospitalizations but not attempts (semaglutide: 0.55; 0.23-1.30; liraglutide: 1.08; 0.55-2.15). Conclusions Relevance Among patients comorbid obesity/type diabetes, semaglutide substantially lower than officially approved medications. be effective treatment AUD, clinical trials are urgently needed confirm these findings.

Language: Английский

Citations

14
Uncovering the impact of alcohol on internal organs and reproductive health: Exploring TLR4/NF‐kB and CYP2E1/ROS/Nrf2 pathways DOI Creative Commons
Eason Qi Zheng Kong, Vetriselvan Subramaniyan, Natasha Sura Anak Lubau

et al.

Animal Models and Experimental Medicine, Journal Year: 2024, Volume and Issue: 7(4), P. 444 - 459

Published: June 9, 2024

This review delves into the detrimental impact of alcohol consumption on internal organs and reproductive health, elucidating underlying mechanisms involving Toll-like receptor 4 (TLR4)/Nuclear factor kappa light chain enhancer activated B cells (NF-kB) pathway Cytochrome P450 2E1 (CYP2E1)/reactive oxygen species (ROS)/nuclear erythroid 2-related 2 (Nrf2) pathways. The TLR4/NF-kB pathway, crucial for inflammatory immune responses, triggers production pro-inflammatory agents type-1 interferon, disrupting balance between antioxidant responses when tissues are chronically exposed to alcohol. Alcohol-induced dysbiosis in gut microbes heightens wall permeability pathogen-associated molecular patterns (PAMPs), leading liver cell infection subsequent inflammation. Concurrently, CYP2E1-mediated metabolism generates ROS, causing oxidative stress damaging cells, lipids, proteins, deoxyribonucleic acid (DNA). To counteract this imbalance, Nrf2 regulates gene expression, inhibiting progression promoting responses. Excessive intake results elevated enzymes (ADH, CYP2E1, catalase), NADH, acetaldehyde, acetate, damage vital such as heart, brain, lungs. Moreover, negatively affects health by hypothalamic-pituitary-gonadal axis, infertility both men women. These findings underscore profound concerns associated with alcohol-induced damage, emphasizing need public awareness regarding intricate interplay multi-organ impacts consumption.

Language: Английский

Citations

11
Combined pharmacological and psychosocial interventions for alcohol use disorder DOI
Silvia Minozzi, Giusy Rita Maria La Rosa, Francesco Salis

et al.

Cochrane library, Journal Year: 2025, Volume and Issue: 2025(3)

Published: March 20, 2025

Language: Английский

Citations

1
Alcohol Use Disorder Diagnoses Among Individuals Who Take HIV Preexposure Prophylaxis DOI Creative Commons
Anton L.V. Avanceña, Godwin Okoye, Rishit Yokananth

et al.

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(4), P. e257295 - e257295

Published: April 25, 2025

Importance Alcohol use disorder (AUD) may negatively affect preexposure prophylaxis (PrEP) adherence and continuation, reducing PrEP effectiveness. Objective To estimate the prevalence of factors associated with AUD diagnoses among commercially insured individuals who take PrEP. Design, Setting, Participants This retrospective cohort study used US health care claims data to identify aged 16 64 years received at least 1 new prescription between January 1, 2014, December 31, 2021. Data were analyzed from June 2024 February 2025. Exposure Sociodemographic characteristics included patient age, sex, geographic location, employment status, type insurance. Clinical sexually transmitted infection (STI) diagnosis testing, psychotherapy services, other mental conditions. Main Outcomes Measures The main outcome was an within 6 months before or after date initiation. Among diagnosis, receipt medications for (MAUDs), including Food Drug Administration (FDA)–approved MAUDs (acamprosate, disulfiram, oral injectable naltrexone) non–FDA-approved (baclofen, gabapentin, topiramate) determined. Results 43 913 receiving (mean [SD] 35.8 [10.94] years; 35 027 [90.1%] male assigned birth). There 6274 (14.29%) had 1245 (2.84%) 5029 (11.45%) their initiation, respectively. sociodemographic clinical that similar whether diagnosed sex birth (before: adjusted odds ratio [aOR], aOR, 0.62; 95% CI, 0.52-0.73; after: 0.81; 0.73-0.90) presence such as depression 3.26; 2.78-3.84; 3.17; 2.88-3.49), anxiety 2.16; 1.83-2.55; 2.24; 2.04-2.46), any substance 14.54; 12.46-16.96; 13.09; 11.82-14.49). 531 (8.46%) FDA-approved MAUD 883 (14.07%) a claim MAUD. Conclusions Relevance population-based found nearly 15% took initiation; more likely have co-occurring conditions, less than 9% These findings suggest interventions are needed improve services

Language: Английский

Citations

1
A cascade of care for alcohol use disorder: Using 2015–2019 National Survey on Drug Use and Health data to identify gaps in past 12‐month care DOI
Carrie M. Mintz, Sarah M. Hartz,

Sherri L. Fisher

et al.

Alcoholism Clinical and Experimental Research, Journal Year: 2021, Volume and Issue: 45(6), P. 1276 - 1286

Published: May 16, 2021

Although effective treatments exist, alcohol use disorder (AUD) is undertreated. We used a cascade of care framework to understand gaps in for persons with AUD.Using 2015-2019 National Survey on Drug Use and Health data, we evaluated the following steps care: (1) adult prevalence AUD; (2) proportion adults AUD who utilized health past 12 months; (3) screened about their use; (4) received brief intervention misuse; (5) information treatment (6) treatment. Analyses were stratified by severity.Of 214,505 included sample, weighted was 7.8% (95% CI 7.6-8.0%). Cascades showed majority individuals months [81.4% 80.7-82.1%)] [69.9% 68.9-70.8%)]. However, only minority subsequent care, including 11.6% 11.0-12.2%) reported receiving intervention, 5.1% 4.6-5.6%) referred treatment, 5.8% 5.4-6.3%) Similar patterns observed when cascades severity.Persons commonly utilize are often use, but few receive Healthcare settings-particularly primary settings-represent prime opportunity implement improve outcomes this high-risk population.

Language: Английский

Citations

53