The Lancet Psychiatry, Journal Year: 2023, Volume and Issue: 10(6), P. 372 - 373
Published: May 1, 2023
Language: Английский
Vaccine, Journal Year: 2025, Volume and Issue: 55, P. 127067 - 127067
Published: March 31, 2025
Language: Английский
Citations
0
BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 22, 2024
Abstract Background Most studies on the impact of COVID-19 pandemic depression burden focused earlier phase specific to lockdowns, but longer-term is less well-studied. In this population-based cohort study, we examined short-term and long-term impacts incidence healthcare service use among patients with depression. Methods Using territory-wide electronic medical records in Hong Kong, identified all aged ≥ 10 years new diagnoses from 2014 2022. We performed an interrupted time-series (ITS) analysis examine changes medically attended before during pandemic. then divided into nine cohorts based year studied their initial ongoing patterns until end applied generalized linear modeling compare rates diagnosis between newly diagnosed A separate ITS explored prevalent Results found immediate increase (RR = 1.21, 95% CI: 1.10–1.33, p < 0.001) population after began non-significant slope change, suggesting a sustained effect Subgroup showed that increases were significant adults older population, not adolescents. Depression used 11% fewer resources than pre-pandemic first year. Pre-existing also had decrease 16% overall all-cause since pandemic, positive change indicating gradual rebound over 3-year period. Conclusions During provision for was suboptimal face increased demand generated by increasing Our findings indicate need improve mental health resource planning preparedness future public crises.
Language: Английский
Citations
2
PLoS Medicine, Journal Year: 2024, Volume and Issue: 21(12), P. e1004457 - e1004457
Published: Dec. 5, 2024
Background Clozapine is widely regarded as a highly efficacious psychotropic drug that largely underused worldwide. Recent disproportionality analyses and nationwide case-control studies suggested potential association between clozapine use hematological malignancy (HM). Nevertheless, the absolute rate difference not well-established due to absence of analytic cohort studies. The clinical significance such risk remains unclear. Methods findings We extracted data from territory-wide public healthcare database January 2001 August 2022 in Hong Kong conduct retrospective study anonymized patients aged 18 + years with diagnosis schizophrenia who used or olanzapine (drug comparator similar chemical structure pharmacological mechanisms) for 90 days, at least 2 prior other antipsychotic records within both groups. Weighted by inverse probability treatment (IPTW) based on propensity scores, Poisson regression was estimate incidence ratio (IRR) HM users. also estimated. In total, 9,965 median follow-up period 6.99 (25th 75th percentile: 4.45 10.32 years) were included, among which 834 After IPTW, demographic characteristics users comparable those had significant weighted IRR 2.22 (95% confidence interval (CI) [1.52, 3.34]; p < 0.001) compared estimated 57.40 CI [33.24, 81.55]) per 100,000 person-years. Findings consistent across subgroups age sex. Sensitivity all supported robustness results showed good specificity but no cancers. main limitation this observational residual confounding effects could have arisen lack randomization use. Conclusions Absolute associated small despite 2-fold elevated rate. Given rarity existing blood monitoring requirements, more restrictive indication special warnings may be necessary.
Language: Английский
Citations
2
QJM, Journal Year: 2023, Volume and Issue: 117(2), P. 125 - 132
Published: Oct. 11, 2023
It is unclear how the coronavirus disease 2019 (Covid-19) pandemic has affected multimorbidity incidence among those with one pre-existing chronic condition, as well vaccination could modify this association.
Language: Английский
Citations
6
Influenza and Other Respiratory Viruses, Journal Year: 2024, Volume and Issue: 18(3)
Published: March 1, 2024
ABSTRACT Background Although psychiatric disorders have been associated with reduced immune responses to other vaccines, it remains unknown whether they influence COVID‐19 vaccine effectiveness (VE). This study evaluated risk of hospitalization and estimated mRNA VE stratified by disorder status. Methods In a retrospective cohort analysis the VISION Network in four US states, rate laboratory‐confirmed COVID‐19‐associated between December 2021 August 2022 was compared across diagnoses monovalent vaccination status using Cox proportional hazards regression. Results Among 2,436,999 adults, 22.1% had ≥1 disorder. The incidence higher among patients any versus no (394 vs. 156 per 100,000 person‐years, p < 0.001). Any (adjusted hazard ratio [aHR], 1.27; 95% CI, 1.18–1.37) mood (aHR, 1.25; 1.15–1.36), anxiety 1.33, 1.22–1.45), psychotic 1.41; 1.14–1.74) were each significant independent predictors hospitalization. disorder, aHRs for association 0.35 (95% 0.25–0.49) after recent second dose, 0.08 0.06–0.11) third 0.33 0.17–0.66) fourth unvaccinated patients. Corresponding estimates 65%, 92%, 67%, respectively, similar (68%, 79%). Conclusion Psychiatric increased However, provided protection regardless status, highlighting its benefit individuals disorders.
Language: Английский
Citations
1
International Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 146, P. 107149 - 107149
Published: June 21, 2024
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 17, 2024
People who use drugs (PWUD) are at a high risk of contracting and developing severe coronavirus disease 2019 (COVID-19) other infectious diseases due to their lifestyle, comorbidities, the detrimental effects opioids on cellular immunity. However, there is limited research vaccine responses in PWUD, particularly regarding role that T cells play immune response acute respiratory syndrome 2 (SARS-CoV-2). Here, we show before vaccination, PWUD did not exhibit an increased frequency preexisting cross-reactive SARS-CoV-2 that, despite inhibitory have T-cell immunity, standard vaccination can elicit robust polyfunctional CD4+ CD8+ were similar those found controls. Our findings indicate stimulates effective highlight targeted as essential public health instrument for control COVID-19 this group high-risk patients.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)
Published: Aug. 2, 2024
Abstract People with COVID-19 can experience post-acute sequelae of SARS-CoV-2 (PASC). Studies on risk factors PASC outcomes are ongoing, especially for endocrine system-related diseases that may impact the cardiovascular system. Cardiac-related is one burdens after infection. This study aimed to examine cardiac-related PASC. In this nested case-control study, we obtained electronic health records (EHRs) database from Hong Kong Hospital Authority. We defined cases as patients at least and controls without any applied incidence density sampling matched age sex a 1:10 ratio. Multivariable conditional logistic regression was used determine associations between A total 455 individuals 3,423 were in underlying cohort. COVID-19-associated hospitalisation (aOR: 1.41, 95% CI: 1.03–1.93) peripheral vascular disease 2.98, 1.31–6.79) associated an increased likelihood Higher doses vaccine (2 doses: 0.68 [0.52–0.89]; ≥3 0.56 [0.40–0.78]) more frequent healthcare utilization visits 0.95, 0.92–0.97) lower first among Chinese population. identified vaccination protective against PASC, which should be prioritized high-risk patients.
Language: Английский
Citations
0
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 8, 2024
ABSTRACT Background Recent disproportionality analyses and nationwide case-control studies suggested a potential association between clozapine use hematological malignancy (HM). Nevertheless, the absolute rate difference is unclear due to absence of cohort studies. Methods We extracted data from territory-wide public healthcare database in Hong Kong build retrospective anonymized patients aged 18+ with diagnosis schizophrenia who used or olanzapine (drug comparator highly similar chemical structure pharmacological mechanisms) for 90+ days, at least two prior other antipsychotic records within both groups. Weighted by inverse probability treatment based on propensity scores, Poisson regression was estimate incidence ratio (IRR) HM users. The also estimated. Results In total, 9,965 were included, 834 users, had significant IRR 2.22 (95% CI 1.52, 3.34) compared Absolute estimated be 57.40 33.24, 81.55) per 100,000 person-years. Findings consistent across sub-groups age sex terms effect size, although non-significant those 65 older. Sensitivity all supported robustness results showed good specificity but no cancers. Conclusion very small there twofold elevated rate. Pharmacotherapies may consider this rare risk addition known side effects.
Language: Английский
Citations
0
2022 IEEE 46th Annual Computers, Software, and Applications Conference (COMPSAC), Journal Year: 2024, Volume and Issue: unknown, P. 833 - 842
Published: July 2, 2024
Language: Английский
Citations
0