Prenatal and Postnatal Ambient Air Pollution and Kawasaki Disease DOI Creative Commons
Penghui Yang, Jing Zhang, Kai‐Jun Zhang

et al.

JACC Advances, Journal Year: 2025, Volume and Issue: 4(4), P. 101651 - 101651

Published: March 14, 2025

Accumulating evidence indicates associations between ambient air pollution and Kawasaki disease (KD), but the results remain inconsistent. This systematic review meta-analysis aimed to comprehensively summarize current on effects of pollutants KD. The PubMed, Web Science, Embase, Scopus databases were searched up January 18, 2025 for studies investigating A fixed- or random-effects model was used calculate pooled ORs with 95% CIs an increase in pollutant concentration 10 μg/m3. risk bias assessed using Risk Bias In Nonrandomized Studies Exposures tool, quality by Grading Recommendations, Assessment, Development, Evaluations framework. protocol registered PROSPERO (CRD42024545321). Thirteen 124,857 participants included. Seven at high bias. revealed increased KD after short-term postnatal exposure PM2.5 (OR: 1.011; CI: 1.003-1.019; I2 = 0%; high-quality evidence) PM10 1.004; 1.000-1.008; 38%; evidence), as well long-term 1.415; 1.179-1.697; 41%; evidence). Prenatal carbon monoxide, nitric oxide, nitrogen oxides, sulfur dioxide; oxide; monoxide oxides also associated occurrence. Both prenatal several are

Language: Английский

Serum Olink Targeted Proteomics Identifies IL-17A as a Prospective Inflammatory Marker for the Prediction and Diagnosis of Kawasaki Disease DOI Creative Commons
Xiaoxuan Tu, Xueqi Chen,

Liyan Xu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 3093 - 3103

Published: March 1, 2025

Kawasaki disease (KD) is an acute febrile vasculitis and the leading cause of acquired heart in children. However, early diagnosis KD remains challenging, its pathogenic mechanisms are yet to be fully elucidated. This study utilized Olink Targeted Proteomics analyze serum protein profiles identify potential diagnostic biomarkers for patients with KD. Based on children final diagnosis, they were categorized into either group or control (FC) group. Serum samples from each randomly selected analyzed using Target 96 Inflammation panel. A retrospective analysis clinical data was also conducted. By integrating results data, receiver operating characteristic (ROC) curve performed determine critical thresholds identified biomarkers. 25 differentially expressed proteins, 18 upregulated 7 downregulated proteins Using LASSO regression analysis, we 5 biomarkers, IL-17A, CCL23, SCF, TWEAK, NT-3, that could used distinguish FC. Among these, IL-17A exhibited greatest fold change. Additionally, a subset participants underwent cytokine testing within first days fever onset during hospitalization. Our this found IL-17 levels significantly elevated subsequently diagnosed suggest inflammation-associated strongly linked family, especially showed best correlation, providing clinicians new biomarker

Language: Английский

Citations

1
Update on Diagnosis and Management of Kawasaki Disease: A Scientific Statement From the American Heart Association DOI
Nicholas Houska, Megan Albertz, Richard J. Ing

et al.

Journal of Cardiothoracic and Vascular Anesthesia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Gut microbiota, inflammatory cytokines, and Kawasaki disease: a Mendelian randomization study and mediation analysis DOI
Ji‐Gan Wang,

Hui‐Hong Dou,

Qiujuan Liang

et al.

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

Citations

0
Interplay of gut microbiota in Kawasaki disease: role of gut microbiota and potential treatment strategies DOI
Qing Yang,

Yaqing Kang,

Wei Tang

et al.

Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Feb. 27, 2025

Kawasaki disease (KD) is an acute systemic immune vasculitis with predominant involvement of the medium and small arteries. It mostly affects pediatric patients, representing most common form in children less than 5 years old. Numerous diseases, especially those related to system, have established links intestinal flora. Recent studies investigated flora changes throughout management KD. There was gut microbiota dysbiosis KD at phase, particularly downregulation short-chain fat acids-producing over-proliferation opportunistic pathogens. The relationship between response therapies individuals specific remains uncertain. Targeted microbial supplements dietary regulation may serve as potential measures alleviate complications thus improve prognosis. This review provides overview current understanding interplay Furthermore, it discusses possibility altering reinstate a healthy condition.

Language: Английский

Citations

0
Unveiling the anti-inflammatory mechanism of exogenous hydrogen sulfide in Kawasaki disease based on network pharmacology and experimental validation DOI Creative Commons

Ling Yu,

Qianwen Luo,

Xiaohui Rao

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 3, 2025

Kawasaki disease (KD) is a severe pediatric vasculitis leading to coronary artery complications. Hydrogen sulfide (H2S), recognized endogenous gasotransmitter with anti-inflammatory properties, offers potential as novel treatment for KD through its cardiovascular benefits. However, the specific effects and underlying mechanisms remain unclear. The objective of present study investigate therapeutic exogenous H2S in using network pharmacology experimental validation. By online database searches, total 405 pharmacological targets H2S, 826 KD-related targets, 107 were identified. Through PPI analysis Cytoscape screening, 9 hub genes filtered, namely TNF, IL6, JUN, AKT1, IL1B, TP53, NFKB1, MAPK1, RELA. KEGG pathway enrichment indicated that TLR4/MyD88/NF-κB signaling may play crucial role on KD. Additionally, vivo experiments confirmed sodium hydrosulfide (NaHS), an donor, markedly improved body weight, reduced inflammatory pathology arteries, downregulated levels cytokines TNF-α, IL-1β, IL-6. Furthermore, WB NaHS inhibited expression TLR4, MyD88, NF-κB, p-NF-κB. In brief, it first reveal attenuates response via pathway, highlighting approach These findings lay foundation further development H2S-based therapies management.

Language: Английский

Citations

0
Prenatal and Postnatal Ambient Air Pollution and Kawasaki Disease DOI Creative Commons
Penghui Yang, Jing Zhang, Kai‐Jun Zhang

et al.

JACC Advances, Journal Year: 2025, Volume and Issue: 4(4), P. 101651 - 101651

Published: March 14, 2025

Accumulating evidence indicates associations between ambient air pollution and Kawasaki disease (KD), but the results remain inconsistent. This systematic review meta-analysis aimed to comprehensively summarize current on effects of pollutants KD. The PubMed, Web Science, Embase, Scopus databases were searched up January 18, 2025 for studies investigating A fixed- or random-effects model was used calculate pooled ORs with 95% CIs an increase in pollutant concentration 10 μg/m3. risk bias assessed using Risk Bias In Nonrandomized Studies Exposures tool, quality by Grading Recommendations, Assessment, Development, Evaluations framework. protocol registered PROSPERO (CRD42024545321). Thirteen 124,857 participants included. Seven at high bias. revealed increased KD after short-term postnatal exposure PM2.5 (OR: 1.011; CI: 1.003-1.019; I2 = 0%; high-quality evidence) PM10 1.004; 1.000-1.008; 38%; evidence), as well long-term 1.415; 1.179-1.697; 41%; evidence). Prenatal carbon monoxide, nitric oxide, nitrogen oxides, sulfur dioxide; oxide; monoxide oxides also associated occurrence. Both prenatal several are

Language: Английский

Citations

0