Lung damage in SARS‐CoV‐2 patients: An autopsy study in the era of vaccination

European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Abstract Aims The contribution of SARS‐CoV‐2 infection on lung damage and the effect vaccination either containing number deaths or mitigating has not been systematically investigated. Methods Post‐mortem analysis was performed among consecutive in‐patients with COVID‐19 deceased in Province Trieste (2020–2022). outcomes study were (i) rates in‐hospital mortality, (ii) to death, (iii) histological extent injury (iv) impact vaccination. Results A total 1038 hospitalized patients who died autopsied deep lungs a randomly selected sample 508 cases. Among them, (a) cause death ( n = 90), (b) contributing 304) (c) an accompanying feature 114). incidence as primary mortality decreased over time (23.8% 2020, 20.9% 2021 7.9% 2022). On multivariable analysis, (any dose) independently associated lower related (HR .15, p < .001), after adjusting for other independent predictors. 172 vaccinated at least two doses death: 93% triple‐vaccinated, 7% double‐vaccinated. had greater frequency pneumonia severity score 0 1 (20.3% vs. 5.4% 7.7%, .001, respectively), substantially proportion 3 (26.2% 55.1%, .001) compared unvaccinated patients. Conclusions reduced may have ability mitigate damage.

Language: Английский

---

Real world evidence for public health decision-making on vaccination policies: perspectives from an expert roundtable

Expert Review of Vaccines, Journal Year: 2023, Volume and Issue: 23(1), P. 27 - 38

Published: Dec. 12, 2023

Introduction Influenza causes significant morbidity and mortality, but influenza vaccine uptake remains below most countries' targets. Vaccine policy recommendations vary, as do procedures for reviewing appraising the evidence.

Language: Английский

---

Effectiveness and safety of COVID-19 vaccination in people with blood cancer

European Journal of Cancer, Journal Year: 2024, Volume and Issue: 201, P. 113603 - 113603

Published: Feb. 5, 2024

Background People with blood cancer have increased risk of severe COVID-19 outcomes and poor response to vaccination. We assessed the safety effectiveness vaccines in this vulnerable group compared general population. Methods Individuals aged ≥12 years as 1st December 2020 QResearch primary care database were included. adjusted vaccine (aVE) against COVID-19-related hospitalisation death people using a nested matched case-control study. Using self-controlled case series methodology, we 56 pre-specified adverse events within 1-28 days first, second or third dose without cancer. Findings The cohort comprised 12,274,948 individuals, whom 81,793 had protective cancer, although they less effective, particularly hospitalisation, In population, aVE was 64% (95% confidence interval [CI] 48%-75%) 14-41 after dose, 80% CI 78%-81%) Against mortality, >80% dose. found no significant difference any between Interpretation Our study provides robust evidence which supports use vaccinations for

Language: Английский

---

Changes in sick notes associated with COVID-19 from 2020 to 2022: a cohort study in 24 million primary care patients in OpenSAFELY-TPP

BMJ Open, Journal Year: 2024, Volume and Issue: 14(7), P. e080600 - e080600

Published: July 1, 2024

Objectives Long-term sickness absence from employment has negative consequences for the economy and can lead to widened health inequalities. Sick notes (also called ‘fit notes’) are issued by general practitioners when a person cannot work reasons more than 7 days. We quantified sick note rate in people with evidence of COVID-19 2020, 2021 2022, as an indication burden recovering COVID-19. Design Cohort study. Setting With National Health Service (NHS) England approval, we used routine clinical data (primary care, hospital testing records) within OpenSAFELY-TPP database. Participants People 18–64 years recorded positive test or diagnosis 2020 (n=365 421), (n=1 206 555) 2022 321 313); population matched age, sex region 2019 (n=3 140 326), 439 534), (n=4 571 469) 818 870); hospitalised pneumonia (n=29 673). Primary outcome measure Receipt primary care. Results Among SARS-CoV-2 diagnosis, was 4.88 per 100 person-months (95% CI 4.83 4.93) 2.66 2.64 2.67) 1.73 1.72 1.73) 2022. Compared region-matched population, adjusted HR receipt over entire follow-up period (up 10 months) 4.07 4.02 4.12) decreasing 1.57 1.56 1.58) The highest first 30 days postdiagnosis all years. COVID-19, after adjustment, lower pneumonia. Conclusions Given under-recording postacute COVID-19-related symptoms, these findings contribute valuable perspective on long-term effects Despite likely underestimation rate, were frequently compared those without, even era most vaccinated. Most occurred postdiagnosis, but increased risk several months may provide further impact.

Language: Английский

---

Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients’ records at source using OpenSAFELY

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 10, 2024

Abstract Background Ethnicity is known to be an important correlate of health outcomes, particularly during the COVID-19 pandemic, where some ethnic groups were shown at higher risk infection and adverse outcomes. The recording patients’ in primary care can support research efforts achieve equity service provision outcomes; however, coding ethnicity present complex challenges. We therefore set out describe detail with a view supporting use this data wide range settings, as part wider robustly define methods using administrative data. Methods completeness consistency OpenSAFELY-TPP database, containing linked hospital records > 25 million patients England. also compared breakdown that 2021 UK census. Results 78.2% registered on 1 January 2022 had their recorded records, rising 92.5% when supplemented was for women than men. rate ranged from 77% South East England 82.2% West Midlands. rates chronic or other serious conditions. For each five broad groups, within 2.9 percentage points population Census whole. multiple 98.7% latest ethnicities matched most frequently coded ethnicity. Patients whose categorised Other likely have discordant (32.2%). Conclusions Primary OpenSAFELY over three quarters all patients, combined sources high level completeness. overall distribution across English practices similar Census, regional variation. This report identifies best available codelist electronic record

Language: Английский

---