International Journal of Epidemiology, Journal Year: 2024, Volume and Issue: 53(5)
Published: Aug. 14, 2024
Language: Английский
Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(3), P. 451 - 465
Published: Jan. 12, 2024
Parkinson’s disease is the world’s fastest growing brain disorder, and exposure to environmental toxicants principal reason. In this paper, we consider alternative, but unsatisfactory, explanations for its rise, including improved diagnostic skills, aging populations, genetic causes. We then detail three that are likely among main causes of disease— certain pesticides, solvent trichloroethylene, air pollution. All ubiquitous, many affect mitochondrial functioning, all can access humans via various routes, inhalation ingestion. reach hopeful conclusion most thus preventable help create a world where increasingly rare.
Language: Английский
Citations
21
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 112 - 112
Published: Jan. 19, 2024
Parkinson’s disease is the second most common neurodegenerative and increasing in incidence. The combination of motor non-motor symptoms makes this a devastating for people with their care givers. characterised by mitochondrial dysfunction neuronal death substantia nigra, reduction dopamine, accumulation α-synuclein aggregates neuroinflammation. microbiome–gut–brain axis also important disease, involved spread inflammation aggregated α-synuclein. mainstay treatment dopamine replacement therapy, which can reduce some signs. There need additional options to supplement available medications. Photobiomodulation (PBM) form light therapy that has been shown have multiple clinical benefits due its enhancement electron transport chain subsequent increase membrane potential ATP production. PBM modulates cellular signalling inflammation. Clinically, used decades improve wound healing, treat pain, swelling heal deep tissues. Pre-clinical experiments indicated signs provide neuroprotection. This effect seen whether directed head animal or other parts body (remotely). A small number trials given weight possibility using both may potentially slow progression.
Language: Английский
Citations
12
Gastro Hep Advances, Journal Year: 2024, Volume and Issue: 3(4), P. 519 - 534
Published: Jan. 1, 2024
Language: Английский
Citations
12
EFSA Supporting Publications, Journal Year: 2024, Volume and Issue: 21(2)
Published: Feb. 1, 2024
Scientific interest in the use of environmental microbiomes for risk assessment is rapidly growing, as exemplified by various EFSA opinions. In absence official regulatory guidelines on how to integrate assessment, aims this report are therefore determine whether microbiome studies can be used such purposes, and propose a roadmap integration assessments under EFSA's remit. The identifies current gaps (in terms knowledge from technical point view) barriers that might delay implementation methods, offers recommendations standardised (multi-)omics techniques purposes. Our main findings identified five priorities: (i) defining core (what it encompasses what made of, including identification bioindicators) assess impact any type disturbance; (ii) standardising methodologies protocols, sampling interpretation, guarantee comparability analyses; (iii) developing tools facilitate interpretation; (iv) collecting microbiome-based data shared, curated maintained databases; (v) setting up European Network Microbiome Laboratories reach an agreement standardise studies, interactions between researchers access or samples, actively include multiple stakeholders discussions involving assessment. There both short- longer-term priorities, all which highlight need mobilise concurrently different agencies institutions, well research. also points out capacity building training, acceptance emerging technology, communication issues. These will hopefully contribute elaboration widely accepted framework dealing with.
Language: Английский
Citations
8
Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(3), P. 131 - 132
Published: Jan. 2, 2024
Language: Английский
Citations
6
Movement Disorders, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 27, 2024
Abstract The age‐standardized prevalence of Parkinson's disease (PD) has increased substantially over the years and is expected to increase further. This emphasizes need identify modifiable risk factors PD, which could form a logical entry point for prevention PD. World Health Organization (WHO) recommended reducing exposure specific environmental that have been reported be associated with in particular pesticides, trichloroethylene (TCE), air pollution. In this review we critically evaluate epidemiological biological evidence on associations these PD whether putative are causal. We conclude when considered isolation, it difficult determine causal, large part because decades‐long lag between relevant exposures incidence manifest However, tandem from complementary research lines (such as animal models), increasingly likely reflect harmful causal effects. Fundamentally, whilst highlight some gaps require further attention, believe current base sufficiently strong enough support our call stronger policy action. © 2024 Author(s). Movement Disorders published by Wiley Periodicals LLC behalf International Parkinson Disorder Society.
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 10, 2025
As glyphosate's application becomes increasingly widespread across the globe, its potential adverse effects on humans have garnered growing concerns. Little evidence has revealed associations between glyphosate and glucose homeostasis. A total of 2094 individuals were recruited from NHANES 2013–2018. Urinary glyphosate, alkaline phosphatase (ALP), fasting plasma (FPG), insulin, glycated hemoglobin A1c (HbA1c) measured. Homeostatic model assessment beta-cell function (HOMA2-β), insulin resistance (HOMA2-IR), sensitivity (HOMA2-IS) assessed. Generalized linear models mediation analyses fitted to estimate homeostasis, ALP. demonstrated a statistically significant positive association with FPG HbA1c in dose–response manner, while showing negative HOMA2-β. Each doubling increase urinary was associated 1.13%, 1.50%, − 2.80% alteration FPG, HbA1c, HOMA2-β, respectively. Obesity modified dyshomeostasis stronger obese individuals. In addition, elevated ALP significantly mediated proportions 9.91% 20.23%, Environmental exposure dyshomeostasis, which more pronounced partly by
Language: Английский
Citations
0
Arquivos de Neuro-Psiquiatria, Journal Year: 2025, Volume and Issue: 83(03), P. 001 - 010
Published: March 1, 2025
The etiology of Parkinson's disease (PD) is complex and multifactorial, depending on interactions involving environmental/lifestyle genetic factors. aspects the are becoming well characterized, while environmental factors still need further investigation. In present narrative review, we have described most concrete evidence associations between risk developing PD. Physical activity, healthy dietary patterns, smoking, caffeine intake protective against Head trauma, consumption milk dairy products, pesticide exposure were associated with a higher alcohol consumption, living in rural areas, farming, water PD controversial. Results several studies strongly suggest that diabetes mellitus factor for development PD, as pre-diabetic state. Lower serum levels uric acid an increased worse clinical features faster progression symptoms. effects nonsteroidal antiinflammatory drugs use Several other potentially PD: pollutants such organic solvents, to sunlight, vitamin D deficiency, bullous pemphigoid, bipolar disorder, inflammatory bowel disease, irritable syndrome, certain infections agents, essential tremor. Environmental important markers Understanding these risks could lead implementation risk-modifying actions
Language: Английский
Citations
0
Chemosphere, Journal Year: 2025, Volume and Issue: 377, P. 144348 - 144348
Published: April 9, 2025
Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder worldwide, and no effective cure currently available. Neuropathologically, PD characterized by selective degeneration of dopaminergic neurons in substantia nigra accumulation alpha-synuclein (aSyn)-rich proteinaceous inclusions within surviving neurons. As a multifactorial disorder, approximately 85 % cases are sporadic with unknown etiology. Among many risk factors implicated PD, exposure to neurotoxic pesticides stands out as significant contributor. While effects still uncharacterized, it has already been shown that rotenone, paraquat, maneb, dieldrin affect critical cellular pathways, including mitochondrial proteasomal dysfunction, aSyn aggregation, autophagy dysregulation, disruption dopamine metabolism. With constant rise pesticide usage meet demands growing human population, environmental contamination subsequent development also increasing. This review explores molecular mechanisms which influences development, shedding light on their role pathogenesis highlighting need for preventative measures regulatory oversight mitigate these risks.
Language: Английский
Citations
0
Journal of Oral Rehabilitation, Journal Year: 2024, Volume and Issue: 51(8), P. 1645 - 1652
Published: May 20, 2024
Abstract Background and Objective Parkinson's disease (PD) poses a range of challenges, including oral health issues, that significantly impact the patient's quality life. Despite growing awareness PD, receives limited attention. To shed light on this matter, personal scoping review explores perspectives Professor K.G. Raphael, who is both professional PD patient, various aspects in PD. Methods Through semi‐structured interviews, Prof. Raphael shares her insights complexities as patient to compose an agenda for care, research, education, patients. Results She emphasises importance interdisciplinary collaboration education. Additionally, identifies crucial research areas, such exploring role microbiome assessing exercise Conclusion This study resulted agendas improve advocating holistic approach enhance patients' well‐being. its limitations, highlights imperative integrating into broader management emphasising empowerment.
Language: Английский
Citations
2