Transfusion,
Journal Year:
2024,
Volume and Issue:
64(6), P. 1025 - 1039
Published: April 25, 2024
Abstract
Background
Limited
studies
have
explored
the
association
between
clinical
symptoms
and
titers
of
SARS‐CoV‐2
antibodies.
Study
Design
Methods
In
this
cross‐sectional
study,
whole‐blood
donors
who
had
experienced
a
confirmed
or
suspected
COVID‐19
infection
completed
questionnaires
at
time
blood
donation.
Plasma
immunoglobulin
G
(IgG)
were
measured
using
an
enzyme‐linked
immunosorbent
assay.
Logistic
regression
models
used
to
calculate
odds
ratios
(ORs)
for
high‐titer
convalescent
plasma
(CCP)
each
variable.
Results
Among
total
386
donors,
120
(31%)
with
IgG
≥1:160
classified
as
donors.
The
multivariable
ORs
(95%
confidence
intervals
[CIs])
high
2.33
(1.45–3.75),
2.11
(1.29–3.43),
1.10
(1.01–1.21),
1.19
(1.00–1.43),
1.97
(1.05–3.71)
sore
throat,
cough,
symptom
count,
fever
duration,
low
(compared
non‐fever),
respectively.
No
significant
was
observed
other
medical
visits
CCP.
CCP
duration
restricted
COVID‐19‐infected
while
associations
throat
cough
remained
in
infected
addition,
visit
positively
associated
but
not
bootstrapped
logistic
models,
reproducible
both
Discussion
Experiencing
overall
We
also
identified
potential
predictors
during
pandemic.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 23, 2024
Abstract
Backgrounds
The
SARS-CoV-2
virus
has
caused
global
outbreaks,
including
the
recent
Omicron
BA.2
wave
in
Shanghai
spring
2022.
While,
viral
load
dynamic
of
infections
with
different
clinical
severity
was
still
unclear.
Methods
A
prospective
cohort
conducted
on
48,830
hospitalized
COVID-19
patients
three
hospitals
Shanghai,
China,
from
23
March
and
15
May
Regular
nucleic
acid
testing
performed
Cycle
threshold
(Ct)
value
tested
by
RT-PCR
used
as
a
proxy
load.
since
initial
detection
risk
factors
were
analyzed.
Results
study
included
31%
asymptomatic
cases,
68%
mild-moderate
1%
severe
1.29%
critical
fatal
cases.
57%
positive
upon
admission,
average
Ct
remained
stable
peak
concentrations
occurring
at
4
days
(median
27.5),
followed
decrease
shedding
time
(VST)
6.1
(IQR,
4.0-8.8
days).
varied
age
severity,
but
values
occurred
similar
times.
Unvaccinated
status,
over
60,
comorbidities
associated
higher
longer
durations.
Asymptomatic
cases
had
40%
contagious
probability
within
6
detection.
Mild-moderate
27%,
>50%
infectiousness
post-symptom
resolution,
respectively.
Conclusion
could
forecast
consequences.
older
people
specific
are
high-risk
groups
high
long
duration.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(3), P. 509 - 509
Published: March 2, 2024
Background:
Understanding
the
immune
response
to
evolving
viral
strains
is
crucial
for
evidence-informed
public
health
strategies.
The
main
objective
of
this
study
assess
influence
vaccination
on
neutralizing
activity
SARS-CoV-2
delta
and
omicron
infection
against
various
variants.
Methods:
A
total
97
laboratory-confirmed
COVID-19
cases
were
included.
To
activity,
we
measured
or
(BA.1
BA.2)
wild-type
(WT),
delta,
BA.1,
BA.2,
with
results
stratified
based
status.
Results:
WT,
variants
was
significantly
higher
in
vaccinated
patients
than
those
unvaccinated
patients.
In
individuals
infected
variant,
decrease
binding
BA.1
BA.2
statistically
significant
(3.9-
2.7-fold,
respectively)
compared
delta.
contrast,
followed
by
breakthrough
improved
cross-neutralizing
variants,
only
1.3-
1.2-fold
decreases
respectively.
Vaccination
that
Conclusions:
associated
different
enhanced
protection
provided
infections
could
have
practical
implications
optimizing
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 8, 2024
Abstract
Vaccination
against
COVID-19
was
integral
to
controlling
the
pandemic
that
persisted
with
continuous
emergence
of
SARS-CoV-2
variants.
Using
a
mathematical
model
describing
within-host
infection
dynamics,
we
estimate
differences
in
virus
and
immunity
due
factors
infecting
variant,
age,
vaccination
history
(vaccination
brand,
number
doses
time
since
vaccination).
We
fit
our
Bayesian
framework
upper
respiratory
tract
viral
load
measurements
obtained
from
cases
Delta
Omicron
infections
Singapore,
whom
majority
only
had
one
nasopharyngeal
swab
measurement.
With
this
dataset,
are
able
recreate
similar
trends
URT
dynamics
observed
past
modelling
studies
fitted
longitudinal
patient
data.
found
greater
potential
than
Delta,
indicating
propensity
establish
infection.
Moreover,
heterogeneities
across
subgroups
could
be
recreated
by
fitting
immunity-related
parameters
as
history-specific,
or
without
age
modification.
Our
results
consistent
notion
immunosenescence
pathogenesis
elderly
individuals,
issue
waning
increased
last
vaccination.
Lastly,
not
subdue
well
it
for
infections.
This
study
provides
insight
into
influence
vaccine-elicited
on
interplay
between
history.
Furthermore,
demonstrates
need
disentangle
host
changes
pathogen
discern
influencing
dynamics.
Finally,
work
way
forward
use
datasets
including
large
patients
repeated
measurements.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(7), P. 1938 - 1938
Published: March 27, 2024
Background:
The
long-term
sequelae
of
coronavirus
disease
2019
(COVID-19)
significantly
affects
quality
life
(QoL)
in
survivors.
Delayed
development
the
adaptive
immune
response
is
associated
with
more
severe
and
a
worse
prognosis
COVID-19.
effects
delayed
on
COVID-19
QoL
are
unknown.
Methods:
We
conducted
prospective
study
to
assess
relationship
between
antibody
acute
phase
infection
naïve
unvaccinated
patients
suffering
from
or
critical
their
12
months
after
hospital
discharge.
12-item
Short
Form
Survey
(SF-12)
questionnaire
was
used
for
assessment
QoL.
SF-12
evaluates
both
mental
physical
components
QoL,
incorporating
component
score
(MCS-12)
(PCS-12).
A
defined
as
testing
negative
anti-spike
SARS-CoV-2
antibodies
at
time
admission.
Results:
included
274
(154
men
120
women).
Of
enrolled
patients,
144
had
response.
These
lower
MCS-12
(p
=
0.002),
but
PCS-12
0.397)
not
different
12-month
follow-up
compared
positive
antibodies.
negatively
irrespective
possible
confounders
0.006;
B
3.609;
ηp2
0.035;
95%
CI
1.069–6.150).
An
MSC-12
below
50
points
positively
0.001;
1.092;
OR
2.979;
1.554–5.711).
Conclusions:
This
confirmed
that,
COVID-19,
result
admission
one
year
Transfusion,
Journal Year:
2024,
Volume and Issue:
64(6), P. 1025 - 1039
Published: April 25, 2024
Abstract
Background
Limited
studies
have
explored
the
association
between
clinical
symptoms
and
titers
of
SARS‐CoV‐2
antibodies.
Study
Design
Methods
In
this
cross‐sectional
study,
whole‐blood
donors
who
had
experienced
a
confirmed
or
suspected
COVID‐19
infection
completed
questionnaires
at
time
blood
donation.
Plasma
immunoglobulin
G
(IgG)
were
measured
using
an
enzyme‐linked
immunosorbent
assay.
Logistic
regression
models
used
to
calculate
odds
ratios
(ORs)
for
high‐titer
convalescent
plasma
(CCP)
each
variable.
Results
Among
total
386
donors,
120
(31%)
with
IgG
≥1:160
classified
as
donors.
The
multivariable
ORs
(95%
confidence
intervals
[CIs])
high
2.33
(1.45–3.75),
2.11
(1.29–3.43),
1.10
(1.01–1.21),
1.19
(1.00–1.43),
1.97
(1.05–3.71)
sore
throat,
cough,
symptom
count,
fever
duration,
low
(compared
non‐fever),
respectively.
No
significant
was
observed
other
medical
visits
CCP.
CCP
duration
restricted
COVID‐19‐infected
while
associations
throat
cough
remained
in
infected
addition,
visit
positively
associated
but
not
bootstrapped
logistic
models,
reproducible
both
Discussion
Experiencing
overall
We
also
identified
potential
predictors
during
pandemic.
