Assessing the impact of Long COVID on healthcare workers’ work – role functioning in tertiary hospitals in Singapore DOI Creative Commons
Zeenathnisa Mougammadou Aribou, Kian Wei Alvin Tan,

See Ming Lim

et al.

Work, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Background Understanding Long COVID's impact on healthcare workers (HCWs) is vital for patient safety and care quality. However, research its prevalence among HCWs in Singapore work lacking. Objective This study aims to assess COVID role functioning two tertiary hospitals, filling a critical gap the literature. Methods Conducted from January April 2023, this evaluated HCWs’ work-role hospitals. over 21, having experienced ≥1 COVID-19 infection, participated an online survey. COVID, defined by NICE criteria, entailed symptoms persisting 4 or more weeks. Work-related was assessed using WRFQv2.0. Descriptive analyses were conducted STATA software. Results Out of 15,882 eligible participants, 573 responded (3.6% response rate). (symptoms ≥4 weeks) 47.5%, notably higher younger (<40 years old), those with moderate/severe infections, multiple infections. had significantly lower WRFQv2.0 mean scores compared without (85.1 vs. 74.3, p < 0.05). Additionally, ≥12 weeks than (85.6 Conclusion underscores potential functioning, especially prolonged symptoms. Tailored adjustments are crucial their successful return pre-illness levels, highlighting importance addressing settings.

Language: Английский

Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement DOI Open Access
Evgeni Gusev, Alexey Sarapultsev

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6389 - 6389

Published: June 9, 2024

Long COVID (LC), also referred to as Post COVID-19 Condition, Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), and other terms, represents a complex multisystem disease persisting after the acute phase COVID-19. Characterized by myriad symptoms across different organ systems, LC presents significant diagnostic management challenges. Central disorder is role low-grade inflammation, non-classical inflammatory response that contributes chronicity diversity observed. This review explores pathophysiological underpinnings LC, emphasizing importance inflammation core component. By delineating pathogenetic relationships clinical manifestations this article highlights necessity for an integrated approach employs both personalized medicine standardized protocols aimed at mitigating long-term consequences. The insights gained not only enhance our understanding but inform development therapeutic strategies could be applicable chronic conditions with similar features.

Language: Английский

Citations

7
Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection DOI
Yuhui Liu,

Quan-Xin Wu,

Qinghua Wang

et al.

Nature Aging, Journal Year: 2024, Volume and Issue: 4(9), P. 1186 - 1193

Published: July 10, 2024

Language: Английский

Citations

6
Long-COVID-19 autonomic dysfunction: An integrated view in the framework of inflammaging DOI

Sergio Giunta,

Chiara Giordani, María De Luca

et al.

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 218, P. 111915 - 111915

Published: Feb. 13, 2024

Language: Английский

Citations

5
Risk Factors for Long COVID in Older Adults DOI Creative Commons

Yunguang Hu,

Yifan Liu, Huiwen Zheng

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 3002 - 3002

Published: Nov. 8, 2023

As time has passed following the COVID-19 pandemic, individuals infected with SARS-CoV-2 have gradually exhibited a variety of symptoms associated long COVID in postacute phase infection. Simultaneously, many countries worldwide, process population aging been accelerating. Within this context, elderly not only become susceptible and high-risk during acute but also considerable risks when confronting COVID. Elderly possess specific immunological backgrounds, aging, their immune systems can enter state known as “immunosenescence”. This further exacerbates “inflammaging” development various comorbidities individuals, rendering them more to Additionally, inflict both physical mental harm upon people, thereby reducing overall quality life. Consequently, impact on people should be underestimated. review seeks summarize infection characteristics intrinsic factors older adults focus it aims explore potential strategies mitigate risk or other emerging infectious diseases among future.

Language: Английский

Citations

11
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans DOI Creative Commons

Sudhanshu Agrawal,

Michelle Tran,

Tara Sinta Kartika Jennings

et al.

Immunity & Ageing, Journal Year: 2024, Volume and Issue: 21(1)

Published: March 21, 2024

Abstract Background Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to resolve resulting hospitalizations mortality. recent COVID-19 pandemic has highlighted this as elderly subjects have emerged vulnerable populations that display increased susceptibility severity SARS-CoV-2. There an urgent need identify the probable mechanisms underlying protect against future outbreaks of such nature. Innate immunity first line defense viruses its decline impacts downstream immune responses. This because dendritic cells (DCs) macrophages key cellular elements innate system can sense respond by producing inflammatory mediators priming CD4 CD8 T-cell Results We investigated changes in responses SARS-CoV-2 function age. Our results using human PBMCs from aged, middle-aged, young indicate activation DCs monocytes response compromised with impairment most apparent pDCs where both aged middle-aged reduced secretion IL-29 confers protection also decreased subjects. In contrast, associated severe including CXCL-8, TREM-1 gene expression data pathways related host dependent decrease concomitant increase pathways. Not only after stimulation but at homeostasis. keeping DC activation, induction cytotoxic T impaired However, baseline accordance enhanced inflammation. Conclusions demonstrate protective anti-viral damaging indicating dysregulated play significant role COVID-19. Furthermore, dysregulation develops early on several these changes. Graphical abstract

Language: Английский

Citations

4
Prevalence and risk factors of long COVID-19 persisting for 2 years in Hainan Province: a population-based prospective study DOI Creative Commons
Daya Zhang,

Chen Chen,

Yunqian Xie

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Coronavirus disease 2019 (COVID-19) can lead to persistent symptoms, sequelae, and other medical complications that may last for weeks or months after recovery. The aim of the study is assess prevalence risk factors long COVID-19 persisting 2 years in Hainan Province, China, aid its recognition, prevention, treatment. Between July August 2022, 960 individuals with confirmed SARS-CoV-2 infection Hainan, were recruited. An epidemiological questionnaire was conducted via phone interviews participants' recovery status years. Among participants, 120 patients (12.5%) experienced at least one complication. most common symptoms cough (33.3%, 40/120), followed by fatigue (25.9%, 31/120), hair loss (23.3%, 28/120), dizziness (20.8%, 25/120). Independent included age over 65, moderate severe infection, chronic diseases, irregular diet, late sleeping, anxiety, fewer than vaccinations (p < 0.05). While infected fully recover, approximately 12.5% experience intermediate long-term effects. This first identify incidence associated longest follow-up time, providing valuable insights timely restoration pre-COVID-19 health.

Language: Английский

Citations

0
Effects of sleep quality on the risk of various long COVID symptoms among older adults following infection: an observational study DOI Creative Commons
Min Du, Ping Yang,

Manchang Li

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 9, 2025

The long-term sequelae of coronavirus disease 2019 (COVID-19) and its recovery have becoming significant public health concerns. Therefore, this study aimed to enhance the limited evidence regarding relationship between sleep quality on long COVID among older population aged 60 years or old. Our included 4,781 COVID-19 patients enrolled from April May 2023, based Peking University Health Cohort. Sleep was assessed using Pittsburgh Quality Index (PSQI) scale. Long evaluated by well-trained professionals through patients' self-reported symptoms. Binary logistic regression models were employed calculate odds ratios (OR) 95% confidence intervals (95% CI). prevalence adults 57.4% (2,743/4,781). Specifically, general symptoms, cardiovascular respiratory gastrointestinal neurological psychiatric symptoms 47.7% (2,282/4,781), 3.4% (163/4,781), 35.2% (1683/4,781), 8.7% (416/4,781) 5.8% (279/4,781), respectively. For each one-point increase in PSQI scores, risk COVID, increased 3% CI: 1.01, 1.06), 7% 1.13), 11% 1.07, 1.15), 20% 1.15, 1.25), In multivariate models, compared with good sleepers, poor exhibited an (aOR = 1.17; 1.03, 1.33), 1.50; 1.06, 2.14), 2.03; 1.61, 2.54), 2.57; CI 1.96, 3.37). findings indicate that is related various manifestations populations. A comprehensive assessment multidisciplinary management may be essential ensure healthy aging future.

Language: Английский

Citations

0
Closing the gap in dementia research by community-based cohort studies in the Chinese population DOI Creative Commons

Xiaowen Zhou,

Zhenxu Xiao, Wanqing Wu

et al.

The Lancet Regional Health - Western Pacific, Journal Year: 2025, Volume and Issue: 55, P. 101465 - 101465

Published: Jan. 21, 2025

Language: Английский

Citations

0
Síntomas prevalentes y características de la población en la COVID prolongada: una revisión de alcance DOI Creative Commons
Karina Marques Prediger, Ana Cristina Ribeiro, Sílvia Carla da Silva André Uehara

et al.

Revista Latino-Americana de Enfermagem, Journal Year: 2025, Volume and Issue: 33

Published: Jan. 1, 2025

Objetivo: mapear la literatura científica sobre las características clínicas y demográficas de COVID prolongada. Método: se trata una revisión alcance basada en los principios recomendados por el JBI directrices del PRISMA para extracción datos, realizada a partir cuatro bases datos. Se utilizó estrategia PCC recolección siendo resultados descritos diagramados. La selección estudios realizó después eliminación duplicados, evaluación individual pares. Resultados: un análisis 13 artículos seleccionados mostró que prolongada afecta todas franjas etarias personas ambos sexos, presentando multiplicidad síntomas, como fatiga (61,5%), disnea (46,1%), alteraciones olfato y/o gusto (38,6%), ansiedad (15,3%) deterioro cognitivo (30,7%). En sexo femenino identificó mayor riesgo desarrollar Conclusión: identificación síntomas prevalentes contribuye salud pública, diagnóstico asistencia afectadas enfermedad. recomiendan futuros abordaje persistencia relación adherencia al esquema vacunación contra COVID-19, sexo, raza/etnia, grado susceptibilidad diferentes etarias, nivel educativo e ingresos, además comorbilidades más frecuentes población.

Citations

0
Sintomas prevalentes e características da população na COVID Longa: uma revisão de escopo DOI Creative Commons
Karina Marques Prediger, Ana Cristina Ribeiro, Sílvia Carla da Silva André Uehara

et al.

Revista Latino-Americana de Enfermagem, Journal Year: 2025, Volume and Issue: 33

Published: Jan. 1, 2025

Objetivo: mapear a literatura científica sobre as características clínicas e demográficas da COVID Longa. Método: trata-se de uma revisão escopo baseada nos princípios preconizados pelo JBI diretrizes do PRISMA para extração dos dados, realizada partir quatro bases dados. Utilizou-se estratégia PCC coleta sendo os resultados descritos diagramados. A seleção estudos foi após remoção duplicatas, avaliação individual em pares. Resultados: análise 13 artigos selecionados mostraram que Longa atinge todas faixas etárias pessoas ambos sexos, apresentando multiplicidade sintomas, como fadiga (61,5%), dispneia (46,1%), alterações no olfato e/ou paladar (38,6%), ansiedade (15,3%) comprometimento cognitivo (30,7%). No sexo feminino identificado risco aumentado desenvolver Conclusão: identificação sintomas prevalentes na contribuem saúde pública, o diagnóstico assistência às acometidas pela doença. Recomenda-se futuros abordagem persistência relação adesão ao esquema vacinal contra COVID-19, sexo, raça/etnia, grau susceptibilidade nas diferentes etárias, nível escolaridade renda além das comorbidades mais recorrentes população.

Citations

0