Gut dysbiosis in primary sarcopenia: potential mechanisms and implications for novel microbiome-based therapeutic strategies

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 28, 2025

Primary sarcopenia is characterized by a progressive loss of skeletal muscle mass, strength, and physical function that occurs with aging. Despite the related adverse or even serious health outcomes, no medications are currently available for treating primary sarcopenia. Here, we discuss recent advancements in understanding mechanistic role gut microbiota-muscle cross-talk sarcopenia, therapeutic implications. The insights encompass causal dysbiosis potentially mediated through microbiota-derived bioactive metabolites, such as short-chain fatty acids (SCFAs), secondary bile acids, their associated signaling pathways, which may be translated into development new microbiome-based treatment diagnostic approaches. Furthermore, identify challenges need addressing future studies to facilitate translation potential novel differential diagnosis older individuals

Language: Английский

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Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 6, 2025

Muscle mass plays a pivotal role in health maintenance, yet its connection to biological aging remains underexplored. This study investigates the association between appendicular skeletal muscle index (ASMI) and phenotypic age(PhenoAge), while examining mediating of systemic inflammation. The analysis included 7,440 participants from NHANES 2011-2018. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated as residuals regressing PhenoAge on chronological age. Multivariable linear regression analyses were performed assess ASMI PhenoAgeAccel. Mediation conducted quantify extent which inflammation contributes this association. Our revealed that higher is linked slower aging, evidenced by lower PhenoAgeAccel (β = -0.48, 95% CI: -0.66 -0.29, p 0.0001). Systemic partially mediated effect, with mediation proportion 35.1%. varied notably across demographic health-related subgroups, being particularly significant females, individuals obesity, those physical activity. These findings highlight critical importance slowing emerging key mediator. public implications are substantial, suggesting targeted interventions-such resistance training, anti-inflammatory diets, personalized medical approaches-could play decelerating improving long-term outcomes.

Language: Английский

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Effects of high‐intensity interval walking training on muscle strength, walking ability, and health‐related quality of life in people with diabetes accompanied by lower extremity weakness: A randomized controlled trial

Journal of Diabetes Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

ABSTRACT Aims/Introduction This study examined the effects of high‐intensity interval walking training (IWT) compared to moderate‐intensity continuous (CWT) on muscle strength, ability, and health‐related quality life (QOL) in people with diabetes accompanied by lower extremity weakness. Materials Methods People low isometric knee extensor strength using a simple manual dynamometer ( n = 50) were screened randomly divided into 2 groups: CWT 25) IWT 25). Both groups instructed physical therapist perform goal 120 min/week over 5‐month period. The primary outcome, mean change secondary outcomes, such as gait speed QOL, measured at baseline end intervention. Results At intervention, there was no significant difference degree extension between two groups. However, increase changes QOL group (gait speed, P < 0.01; 0.05). Conclusions present showed that for weakness did not improve but ability QOL.

Language: Английский

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Integrating frailty interventions into existing care models: a comprehensive approach to enhancing patient outcomes in chronic disease management

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 21, 2025

Frailty syndrome (FS) is a complex and multifaceted condition commonly observed in old adults patients with chronic diseases, often accompanied by cognitive impairments. This review explores the integration of frailty interventions into existing care models to improve patient outcomes, focusing on four key areas. First, it emphasizes importance comprehensive assessment tools identify impairments early, facilitating targeted planning. Second, highlights value personalized interventions, such as dietary modifications, exercise programs, training, tailored individual needs preferences. Third, underscores critical role multidisciplinary teams providing holistic coordinated care, leveraging expertise diverse healthcare professionals. Finally, examines potential technological innovations caregiver support systems enhancing management addressing challenges posed By integrating these approaches, this presents patient-centered framework aimed at mitigating impact improving long-term outcomes. The findings emphasize need for unified strategy that combines interdisciplinary collaboration, advancements address disease management.

Language: Английский

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Associations between sedentary behaviour and sarcopenia among patients aged 40 and older with chronic obstructive pulmonary disease: a cross-sectional study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 29, 2025

Language: Английский

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The impact of lifestyle factors across the life course on sarcopenia and physical frailty

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Purpose of review Muscle health helps maintain locomotor capacity, a key component intrinsic which is required for healthy ageing. Sarcopenia characterized by the age-related decline in muscle mass and strength leading to impaired physical performance, has been described as biological substrate frailty. Both sarcopenia frailty share phenotypic features weakness slowness, lead common adverse outcomes, have potential reversal through early identification intervention. The purpose this present recent evidence impact lifestyle interventions across life course on Recent findings Resistance exercise alone or combined with balance aerobic training part multicomponent program high-quality diets incorporating adequate protein remain mainstay treatment Reducing sedentary time increasing activity, adherence Mediterranean diet, vegetable caffeinated beverage intake, cardiovascular risk factor modification, improving sleep hygiene depressive symptoms may also contribute slowing down health. Summary Lifestyle such mental are effective against Targeting modifications midlife retard further capacity optimize older persons, reducing sarcopenia, their attendant negative outcomes.

Language: Английский

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Effects of 12-month physical and cognitive training on sarcopenia determinants in older adults: a subgroup analysis of a randomised clinical trial

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: Feb. 6, 2025

Abstract Background Low physical activity is a major risk for sarcopenia. Whether training according to guidelines accompanied with cognitive effective on sarcopenia, remains unclear. Aims We investigated whether the effects of 12-month and (PTCT) (PT) grip knee extension strength, muscle mass, walking speed differed between older adults without Methods Community-dwelling ( N = 314, mean age 74.5 ± 3.8 years, 60% women) who did not meet were randomized PTCT PT groups. both groups included supervised home-based multicomponent training. Cognitive (CT) computer-based exercises executive functioning. Sarcopenia was determined European Working Group in Older People 2019 criteria. Generalized estimation equation analysis conducted. Results Compared PT, had no additive effect or participants In pooled data (PT + PTCT) change strength greater sarcopenia n 49) group compared non-sarcopenia 264) (interaction, p =.014). Both improved speed, but statistically significant difference observed. Muscle mass either group. Conclusion Physical recommendations improves maintains Additional benefits these outcomes. Trial registration number ISRCTN52388040 date 20/1/2017.

Language: Английский

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Sense of belonging and its positive association with physical activity levels and negative association with sedentary behaviors in residential aged care facilities in COVID-19 pandemic: a longitudinal study

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Introduction The COVID-19 pandemic reduced physical activity levels and increased sedentary behavior among older adults in residential care facilities. Another effect of this crisis was that facilitating a sense social belonging through in-person activities, such as group exercises or communal meals, became difficult. This study examines the relationship between activity, behavior, adults. Methods longitudinal study, which lasted 10 months, involved 57 Participants completed Échelle de mesure du Sentiment d’Appartenance Sociale ( ESAS ) questionnaire three times wore an accelerometer on their waists for 1 week each time to measure levels. questionnaire, validated tool evaluating adults, measures series questions assess individual’s feelings acceptance intimacy within group. Results were predominantly (7.30 h/day) engaged low-intensity activities (2.9 h/day). They did not meet recommended 150 min/week moderate-to-vigorous activity. high, with mean scores 6.75 ), 7.08 (Acceptance), 6.43 (Intimacy). Light negatively associated time. positively light correlated Conclusion underscores importance reducing By promoting interactions we can enhance well-being population, especially during conditions. study’s findings should inspire future interventions focus these aspects, thereby improving health outcomes facilities

Language: Английский

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Economic autonomy as a determinant of physical activity behavior in Chinese older adults

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 20, 2025

The physical activity of the old people is affected by many factors, and economic situation an important factor affecting activity. However, relationship between autonomy patterns among older adult Chinese has not been fully studied. To investigate association different types adults aged 60 above. Cross-sectional analysis 1,961 participants from 2018 China Health Retirement Longitudinal Study (CHARLS). Economic was categorized into autonomous non-autonomous groups. Physical assessed through type, frequency, duration, purpose, using validated questionnaires. showed positive associations with low moderate-intensity activities (p < 0.05). economically individuals demonstrated higher participation in high-intensity activities, primarily due to work-related demands (78.7%). frequency significantly groups 0.01).

Language: Английский

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Risk factors for sarcopenia in community setting across the life course: A systematic review and a meta-analysis of longitudinal studies

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 133, P. 105807 - 105807

Published: March 1, 2025

Language: Английский

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