Innovative therapeutic strategies using ADHD medications tailored to the behavioral characteristics of patients with chronic pain

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

Chronic pain affects a significant portion of adults and is linked to psychosocial issues, cognitive dysfunction, psychiatric disorders, complicating treatment. Attention deficit hyperactivity disorder (ADHD) increasingly recognized as contributing factor chronic pain, particularly nociplastic with notable prevalence comorbidity between ADHD conditions like fibromyalgia low back pain. behaviors such impulsivity overactivity can exacerbate by leading patients seek risky treatments or discontinue care prematurely. medications are expected alleviate severity improving associated dysfunction addressing central sensitization, fundamental mechanism in Brain abnormalities contribute increased spontaneous activity the anterior cingulate cortex-posterior insular pathway due neuroinflammation, alterations action potential firing, changes transmission pathways spinal dorsal horn. Additionally, norepinephrine synthesis reduced efficiency amplify nociceptive information from periphery facilitate sensitization ADHD. Beyond typical stimulants, reuptake inhibitors, alpha-2 receptor agonists, various antidepressants, mood stabilizers, antipsychotics, Parkinson's disease medications, antidementia have proven effective alleviating symptoms. These for ADHD, may offer innovative solutions managing targeting both cognitive/behavioral observed comorbid Further research into these mechanisms could lead new, more pharmacological condition that often overlooked.

Language: Английский

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Depressive Disorders

Cambridge University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 145 - 157

Published: Jan. 2, 2025

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Cognitive flexibility of male rats is increased by augmented punishment in a reversal learning task but ketamine has no detectable long-term effects

Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

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PSICOFÁRMACOS DISPENSADOS EM UMA FARMÁCIA NO MUNICÍPIO DE JOÃO PESSOA – PB ENTRE JANEIRO A JUNHO DE 2024

Revista Multidisciplinar do Nordeste Mineiro, Journal Year: 2025, Volume and Issue: 8(1), P. 1 - 26

Published: April 30, 2025

Os medicamentos psicofármacos são substâncias que agem no sistema nervoso central (SNC), podem ser divididos em 4 categorias: antidepressivos, antipsicóticos, estabilizadores do humor e ansiolíticos. O objetivo deste estudo foi avaliar os principais dispensados uma farmácia comunitária da cidade de João Pessoa durante meses janeiro a junho 2024. A pesquisa trata-se um descritivo, exploratório, com abordagem quantitativa qualitativa dados respeito dos dez foram obtidos através interno própria farmácia, Linx Big Farma. coletados organizados, processados tabulados software Microsoft Office Excel® 2010. Foram 698 psicofármacos, sendo classe mais comercializada na filial antidepressivos 39,97%, seguida pelos ansiolíticos 39,83%, o pode sugerir intensificação depressão ansiedade população. É possível observar quatro dispensados, três inibidores seletivos recaptação serotonina antidepressivo tricíclico. obteve maior dispensação sertralina 115 unidades, totalizando 41,2%, pela fluoxetina, escitalopram amitriptilina. Essa ratifica entendimento das atuais classes consumidas população farmácias comunitárias para tratamento transtornos mentais, vem fornecer instruções esclarecedoras objetivas uso consciente medicamentos.

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How and when to treat the most common adverse effects of antipsychotics: Expert review from research to clinical practice

Acta Psychiatrica Scandinavica, Journal Year: 2020, Volume and Issue: 143(2), P. 172 - 180

Published: Dec. 11, 2020

As most treatment guidelines for antipsychotics focus on clinical efficacy, we will instead adverse effects and how to manage them. In this review, aim provide an up-to-date resource providers who prescribe have included here "what's new" "what do" numerous antipsychotic-induced effects.A review was performed of relevant literature, studies, randomized trials, systematic reviews. This information combined with the experience authors formulate a practical guide treating emphasis metabolic movement disorder brief mention some others (sedation sexual dysfunction).Antipsychotics are integral part psychiatric care often prescribed lifelong. When choosing antipsychotic, special consideration must be given which undeniable impact quality life can deciding factor in patients' medication compliance. While patients may respond well one specific medication, they still that lead them discontinue it or switch more tolerable but less effective option. However, strategies do exist managing effects, especially allowing better personalization antipsychotic choice.

Language: Английский

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Paraphilia and Hypersexuality in Bipolar I Disorder and Histrionic Personality Disorder: A Case Report

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Paraphilias are rare and often overlooked psychiatric conditions characterized by intense, atypical, recurrent sexual urges or behaviors. This case report describes a 33-year-old woman with comorbid bipolar I disorder histrionic personality disorder, presenting hypersexuality risky practices, suggestive of quantitative paraphilia. The patient's behavior included group encounters, unprotected intercourse, impulsive dissemination explicit images via social media, culminating in Trichomonas vaginalis infection. Management required an interdisciplinary approach, combining pharmacotherapy (lithium carbonate quetiapine), cognitive-behavioral therapy (CBT) targeting impulsivity emotional regulation, psychoeducational interventions emphasizing safe practices impulse control. highlights the interconnected nature severe disorders dysregulation, need for integrated therapeutic strategies to achieve clinical stabilization minimize risks. also underscores gaps specific guidelines managing paraphilic behaviors populations, particularly contemporary sociocultural contexts evolving dynamics. Future studies warranted develop structured, evidence-based approaches address this complex interplay comorbidities paraphilias.

Language: Английский

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What role did serious mental illness play in Jackson Pollock’s drip paintings? Abstract expressionism and possible links to serious mental illness and encrypted images (polloglyphs)

CNS Spectrums, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 1, 2025

The link between creativity and serious mental illness (SMI) is widely discussed. Jackson Pollock one example of a giant in the field art who was both highly creative experiencing an SMI. created new genre known as abstract expressionism ("action painting") defined showing frenetic actions painting. question arises whether his SMI played any role way he drip paintings, especially when overactive manic. Furthermore, did visual hallucinations or enhanced perception associated with mania psychosis facilitate embedding camouflaging images under layers thrown paint? Seeing Pollocks paintings has been controversy ever since these were created. Some experts attribute this to pareidolia-perceiving specific out random ambiguous patterns-a phenomenon be by fractal fuzzy edges such seen Rorschach ink blots well paintings. So, are Pollock's merely images, insert polloglyphs-images that encrypted tell story about inner being-into then disguise them drippings? Here, we explore answers questions discuss included earliest sketches used repeatedly later argue not accidental.

Language: Английский

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Patterns in (es)citalopram prescriptions to Medicaid and Medicare patients in the United States: the potential effects of evergreening

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

Citalopram and escitalopram are among the most used medications key treatments for many psychiatric disorders. Previous findings suggest citalopram prescription rates changing because of patent ending as opposed to evidence a clear therapeutic advantage-so-called "evergreening". This retrospective study focuses on characterizing chronologic geographic variation in use from 2015 2020 US Medicaid Medicare patients. We hypothesized that will decrease with concurrent increase escitalopram, consistent costs per state were obtained State Drug Utilization Database Provider Payment Data. States' annual outside 95% confidence interval considered significantly different average. Overall, decreasing trend an increasing noted both The differences between generic brand drugs, forms being less expensive than brand-name version. Despite limited suggesting have any meaningful or adverse effects, there exists noticeable decline cooccurred prescribing, our hypothesis. Moreover, these general pharmacoepidemiologic trends significant variability. There was disproportionate spending (relative their use) versions medicines relative forms.

Language: Английский

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Evidence-based guidelines for the pharmacological treatment of migraine

Cephalalgia, Journal Year: 2025, Volume and Issue: 45(4)

Published: April 1, 2025

We here present evidence-based guidelines for the pharmacological treatment of migraine. These guidelines, created by Italian Society Study Headache and International Society, aim to offer clear, actionable recommendations healthcare professionals. They incorporate from randomized controlled trials expert-based opinions. The follow Grading Recommendations, Assessment, Development Evaluation approach assessing quality evidence. guideline development involved a systematic review literature across multiple databases, adherence Cochrane methods, structured framework data extraction interpretation. Although provide robust foundation migraine treatment, they also highlight gaps in current research, such as paucity head-to-head drug comparisons need long-term outcome studies. serve resource standardize promote high-quality care different settings.

Language: Английский

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Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor

Clinical Kidney Journal, Journal Year: 2023, Volume and Issue: 16(12), P. 2365 - 2377

Published: Sept. 18, 2023

People living with chronic kidney disease (CKD) frequently suffer from mild cognitive impairment and/or other neurocognitive disorders. This review in two parts will focus on adverse drug reactions resulting as a potentially modifiable risk factor CKD patients. Many patients have substantial burden of comorbidities leading to polypharmacy. A recent study found that seen by nephrologists were the most complex treat because their high number and medications. Due polypharmacy, these may experience wide range reactions. Along progression, accumulation uremic toxins lead blood-brain barrier (BBB) disruption pharmacokinetic alterations, increasing affecting central nervous system (CNS). In dialysis, excretion drugs depend function is severely reduced such toxic levels or its metabolites be reached at relatively low doses, unless dosing adjusted. first discuss how represents for CNS via (i) BBB associated (ii) impact dialysis itself pharmacokinetics.

Language: Английский

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