Recommendation: Mitochondria as a target of micro- and nanoplastic toxicity — R0/PR2

Published: Nov. 30, 2023

Mitochondria are unique organelles to perform critical functions such as energy production, lipid oxidation, calcium homeostasis, and steroid hormone synthesis in eukaryotic cells. The proper functioning of mitochondria is crucial for cellular survival, bioenergetics. Mitochondrial structure function maintained by the mitochondrial quality control system, which consists processes biogenesis, dynamics (fusion/fission), mitophagy, unfolded protein response UPRMT. dysfunction and/or damage associated with initiation progression several human diseases, including neurodegenerative, cardiovascular, age-related diabetes, cancer. Environmental stress contaminants may exacerbate sensitivity causes dysfunction. There growing evidence about impact nanoplastics (NPs) microplastics (MPs) on health function. MPs/NPs were reported trigger oxidative reactive oxygen species eventually change membrane potential. can cross through biological barriers body be internalized cells, potentially altering dynamics, bioenergetics, signaling pathways, thus impacting metabolism This review states effects homeostasis well apoptosis discussed.

Language: Английский

Author comment: Mitochondria as a target of micro- and nanoplastic toxicity — R0/PR1

Published: June 7, 2023

Mitochondria are unique organelles to perform critical functions such as energy production, lipid oxidation, calcium homeostasis, and steroid hormone synthesis in eukaryotic cells. The proper functioning of mitochondria is crucial for cellular survival, bioenergetics. Mitochondrial structure function maintained by the mitochondrial quality control system, which consists processes biogenesis, dynamics (fusion/fission), mitophagy, unfolded protein response UPRMT. dysfunction and/or damage associated with initiation progression several human diseases, including neurodegenerative, cardiovascular, age-related diabetes, cancer. Environmental stress contaminants may exacerbate sensitivity causes dysfunction. There growing evidence about impact nanoplastics (NPs) microplastics (MPs) on health function. MPs/NPs were reported trigger oxidative reactive oxygen species eventually change membrane potential. can cross through biological barriers body be internalized cells, potentially altering dynamics, bioenergetics, signaling pathways, thus impacting metabolism This review states effects homeostasis well apoptosis discussed.

Language: Английский