Association between prognostic nutritional index and all-cause mortality and cardiovascular disease mortality in American adults with non-alcoholic fatty liver disease

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 10, 2025

Background The current research was to investigate the relationship between prognostic nutritional index (PNI) and mortality, with a focus on all-cause cardiovascular disease (CVD) for those non-alcoholic fatty liver (NAFLD). Methods Data from 20,142 patients who participated in National Health Nutrition Examination Survey (NHANES), which carried out 2005 2014, were included this research. To examine PNI both we employed weighted Cox regression models multiple variables. Kaplan–Meier survival curves utilized visualize distribution across different levels of PNI. non-linear association mortality addressed through penalized spline smoothing. Subgroup analyses conducted potential influence relevant clinical variables mortality. precision forecasting outcome assessed as well using time-dependent receiver operating characteristic curve (ROC) analysis. Results analysis linked higher significantly reduced CVD Multivariable demonstrated that increasing consistently lowered risks. With threshold value 50.5, link showed pattern after adjusting confounding factors. confirmed robust associations, particularly race, education, BMI, fibrosis. Time-dependent ROC highlighted strong predictive performance various time points. Conclusion played significant role an effective predictor prognosis individuals diagnosed NAFLD.

Language: Английский

Association between geriatric nutritional risk index and osteoarthritis in aged person over 60: data from NHANES 2005-2018

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 8, 2025

Background Osteoarthritis (OA), a prevalent age-related degenerative joint disorder, demonstrates significant associations with nutritional status. This study examines the prognostic value of Geriatric Nutritional Risk Index (GNRI) in OA risk stratification among elderly individuals. Methods retrospective analysis utilized seven NHANES cycles (2005-2018) encompassing geriatric participants (≥ 60 years) possessing complete GNRI measurements and baseline covariates. For comparative cohort balancing, propensity score matching was executed using inverse probability weighting matched-pairs design, adjusting for age, alcohol consumption, Poverty Income Ratio. Multivariable-adjusted weighted logistic regression quantified GNRI-OA associations, restricted cubic splines (RCS) characterizing nonlinear dynamics. Subgroup analyses were also performed. Results cross-sectional identified 656 cases 3,120 rigorously screened participants. Elevated levels demonstrated association increased populations, correlation remaining robust sensitivity adjusted metabolic confounders. Specifically, ≥ 123.63 associated higher this population. RCS revealed non-linear relationship (p_non-linear < 0.001) between risk, particularly men non-smokers. indicated that males, Hispanic Americans, Non-Hispanic Black people, non-smokers, those low PIR more sensitive to changes GNRI. Conclusion independently prevalence demonstrating status’s pivotal role pathophysiology. The impact on may differ across demographic subgroups, highlighting need personalized approaches managing based

Language: Английский

The association between lifelines diet score and metabolic associated fatty liver disease: a case–control study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 15, 2025

Introduction Adherence to a healthy dietary pattern is fundamental recommendation for the prevention of Metabolic Associated Fatty Liver Disease (MAFLD); however, conclusive evidence regarding optimal remains elusive. Objectives The Lifelines Diet Score (LLDS) novel, evidence-based scoring system designed evaluate diet quality. However, despite extensive research on patterns and liver health, specific relationship between LLDS MAFLD underexplored. This study aims investigate association MAFLD, providing insights into how adherence, as measured by LLDS, may influence risk prevalence MAFLD. Methods case–control enrolled 215 individuals who had recently been diagnosed with 430 controls at King Khalid University Hospital. All participants were aged 20 60 years, data collection occurring from February 2023 January 2025. intake was assessed through utilization validated semi-quantitative food frequency questionnaire, which comprised total 168 distinct items. Logistic regression used estimate Results Out 645 participants, newly patients analyzed. After stratifying based tertiles, those in highest group 78% lower odds than lowest tertile (odds ratio (OR): 0.22; 95% Confidence interval (CI): 0.12–0.36, p trend <0.001). remained robust even after adjustment major confounders. These findings highlight novel assessment health research. Conclusion Our strengthens that adherence (as LLDS) associated risk, accounting further integrating genetic molecular needed refine personalized recommendations prevention.

Language: Английский