Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Clinical and Experimental Obstetrics & Gynecology, Journal Year: 2025, Volume and Issue: 52(2)
Published: Feb. 24, 2025
Background: Perimenopausal women often require hormone replacement therapy (HRT), which is associated with an increased risk of developing breast nodules compared to in other age groups. Consequently, this study aimed identify factors for nodule development perimenopausal and develop a predictive model mitigate these risks. Methods: This prospective cohort included 436 who underwent ultrasound examinations at the Affiliated Hospital Guizhou Medical University, China. Clinical data were collected, 304 cases (70%) assigned modeling group, while remaining 132 (30%) allocated validation group using computerized randomization method. Subsequently, participants each categorized into either control or disease based on presence absence nodules. Risk occurrence from analyzed univariate analysis multivariate logistic regression. A nomogram was subsequently constructed R software. The accuracy discriminative ability evaluated both groups goodness-of-fit curves receiver operating characteristic (ROC) analysis. Results: Factors exhibiting significant differences regression model. results revealed that family relationships, modified Kupperman score, depression, dietary status, estradiol (E2), triglycerides (TG), total cholesterol (TC) independent during perimenopause. In contrast, elevated high follicle-stimulating (FSH) levels identified as protective factor against developed assess validity perimenopause, curves. showed χ2 = 4.936, p 0.764 training 8.642, 0.071 testing group. model’s discrimination by ROC curve, showing area under curve (AUC) 0.941 model, along specificity 91.7%, sensitivity 96.4%. AUC also 0.941, 90.2% 98.4%. Conclusions: Poor unhealthy habits, severe menopausal symptoms, estrogen levels, blood lipid FSH serve approach demonstrates strong power.
Language: Английский
Citations
0
International Dairy Journal, Journal Year: 2024, Volume and Issue: 156, P. 105978 - 105978
Published: May 13, 2024
Language: Английский
Citations
3
Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10
Published: Dec. 18, 2023
Introduction: Human milk delivers critical nutritional and immunological support to human infants. Milk fat globules (MFGs) their associated membranes (MFGMs) contain the majority of lipids many bioactive components that contribute neonatal development health, yet compositions have not been fully defined, mechanisms responsible for formation these structures remain incompletely understood. Methods: In this study, we used untargeted mass spectrometry quantitatively profile protein freshly obtained MFGs paired, physically separated MFGM fractions from 13 samples. We also profiled MFG 9 pooled samples 18 lactating mouse dams. Results: identified 2,453 proteins 2,795 in samples, respectively, 1,577 MFGs. Using paired analyses abundance MFGMs compared (MFGM-MFG; 1% FDR), 699 were more highly abundant (MFGM-enriched), 201 less (cytoplasmic). MFGM-enriched comprised membrane systems (apical plasma multiple vesicular membranes) hypothesized be lipid secretion transport signaling systems. Cytoplasmic included ribosomal proteasomal Comparing between MFGs, found a positive correlation ( R 2 = 0.44, p < 0.0001) relative abundances 1,279 common across species. Discussion: Comparative pathway enrichment reveal similarities trafficking pathways involved identify potentially novel Our results advance knowledge composition quantities greater detail, provide quantitative specifically enriched proteins, core cellular secretion.
Language: Английский
Citations
4
International Journal of Dairy Technology, Journal Year: 2024, Volume and Issue: 77(3), P. 645 - 650
Published: April 1, 2024
The formation of the mammary secretion, proteins, lipids and ions is fundamental importance to dairy industry. cellular interactions which allow secretion protein especially milk fat globules are still controversial. However, electron microscopy provides a basis for straightforward scheme presented as diagram. Each step in process can then be defined, published evidence each assessed areas need further work clearly recognised. We also hope that diagram will act way combining global approaches such proteomics or knockouts with detail microscopy.
Language: Английский
Citations
1
PharmaNutrition, Journal Year: 2024, Volume and Issue: unknown, P. 100418 - 100418
Published: Oct. 1, 2024
Language: Английский
Citations
1
Journal of Dairy Research, Journal Year: 2023, Volume and Issue: 90(4), P. 367 - 375
Published: Nov. 1, 2023
Abstract The milk fat globule membrane (MFGM) is formed by complex cell biological processes in the lactating mammary epithelial which result release of (MFG) into secretory alveolus. MFG bounded a continuous unit (UM), separated from lipid thin layer cytoplasm. This unique apocrine secretion process has been shown all species so far investigated. Once released alveolus there considerable transformation UM with its attached MFGM. stable and expressed shows same transformed MFGM structure. Again, this structure common to mammalian However, explanation very much depends on method investigation. Transmission electron microscope (TEM) studies suggest literal breakdown discontinuous plus cytoplasm patches strands, whereas more recent confocal laser scanning light microscopy (CLSM) indicate separation, UM, two phases, one liquid ordered other disordered. review designed show that TEM CLSM results different views structures once certain deficiencies techniques are factored in.
Language: Английский
Citations
2
Foothill and mountain agriculture and stockbreeding, Journal Year: 2024, Volume and Issue: 75(1), P. 167 - 174
Published: March 28, 2024
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0