From Genes to Worms: A Deep Dive into Helminth Omics

Published: Jan. 1, 2025

Language: Английский

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Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 13, 2025

The “Old Friends Hypothesis” suggests insufficient exposure to symbionts hinders immune development, contributing increased immune-related diseases in the Global North. microbiome is often focus; helminths, potentially also offering health benefits, lack attention. Infection and effect of helminths are influenced perhaps determined by micro-organisms. Mechanisms behind parasite-microbiome interactions poorly understood, despite implications on host health. These typically studied for single helminth species laboratory animal models, overlooking diversity. Reviewing research relationships between microbial diversity yielded 27 publications; most focused human or other mammalian hosts, relying natural rather than experimental inoculation. Only about half investigated outcomes. Remaining knowledge gaps warrant considering additional candidate model systems. Given high helminthiasis burden we propose seeking models South, where a considerable proportion aspects helminth-microbiome took place. Low availability genomic resources however, necessitates more integrative helminthological efforts. substantial similarities systems, several fishes health/disease. More effort could be done establish this cichlids, whose representatives African Great Lakes provide well-delineated, closed system relevant view fish-borne zoonoses water-borne parasites. A good baseline exists these cichlids’ genomics, parasitology, microbiology. We suggest exploring Lake cichlids as hosts diversity,

Language: Английский

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Ecology of vertical tumor transmission in the freshwater cnidarian Hydra oligactis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 18, 2025

Language: Английский

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Does the host matter? Testing the impact of host identity on the microbiome of a trematode parasite

Parasitology Research, Journal Year: 2025, Volume and Issue: 124(3)

Published: March 1, 2025

Language: Английский

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Different trematode parasites in the same snail host: Species‐specific or shared microbiota?

Molecular Ecology, Journal Year: 2023, Volume and Issue: 32(19), P. 5414 - 5428

Published: Aug. 24, 2023

The concept that microbes associated with macroorganisms evolve as a unit has swept evolutionary ecology. However, this idea is controversial due to factors such imperfect vertical transmission of microbial lineages and high microbiome variability among conspecific individuals the same population. Here, we tested several predictions regarding microbiota four trematodes (Galactosomum otepotiense, Philophthalmus attenuatus, Acanthoparyphium sp. Maritrema novaezealandense) parasitize snail host We predicted each parasite species would harbour distinct microbiota, composition similarity decreasing increasing phylogenetic distance species. also trematode co-infecting individual influence other's microbiota. detected significant differences in alpha beta diversity, well differential abundance, found no evidence phylogenetically closely related had more similar uncovered indicator bacterial taxa were significantly Trematode sharing showed mostly one-sided exchanges, community one approaching other. hypothesize natural selection acting on specific may be important maintain horizontally acquired microbes, playing role. In particular, consistent diverse bacteriota than others, potentially result stronger stabilizing pressures. conclude species-specific processes shape assembly different exploiting

Language: Английский

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Helminth-host-environment interactions: Looking down from the tip of the iceberg

Journal of Helminthology, Journal Year: 2023, Volume and Issue: 97

Published: Jan. 1, 2023

Abstract In 1978, the theory behind helminth parasites having potential to regulate abundance of their host populations was formalized based on understanding that those macroparasites reduce survival or fecundity infected population would be among forces limiting unregulated growth. Now, 45 years later, a phenomenal breadth factors directly indirectly affect host–helminth interaction has emerged. Based largely publications from past 5 years, this review explores three lenses: perspective helminth, host, and environment. What biotic abiotic as well social intrinsic helminths? are negative, positive, implications for communities? larger-scale dynamic environment, what evidence do we have human-induced environmental change will modify dynamic? The overwhelming message is context everything. Our second-, third-, fourth-level interactions extremely limited, far drawing generalizations about myriad microbe-helminth-host interactions.Yet intricate, co-evolved balance complexity these may provide level resilience in face global change. Hopefully, albeit limited compilation recent research spark new interdisciplinary studies, application One Health approach all systems generate testable conceptual frameworks encompass our host–helminth–environment triad.

Language: Английский

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Microbial artists: the role of parasite microbiomes in explaining colour polymorphism among amphipods and potential link to host manipulation

Journal of Evolutionary Biology, Journal Year: 2024, Volume and Issue: 37(9), P. 1009 - 1022

Published: July 11, 2024

Abstract Parasite infections are increasingly reported to change the microbiome of parasitized hosts, while parasites bring their own microbes what can be a multi-dimensional interaction. For instance, recent hypothesis suggests that microbial communities harboured by may play role in well-documented ability many manipulate host phenotype, and explain why degree which phenotype is altered varies among conspecific parasites. Here, we explored whether microbiomes both hosts associated with variation manipulation Using colour quantification methods applied digital images, investigated uninfected Transorchestia serrulata amphipods, as well amphipods infected Plagiorhynchus allisonae acanthocephalans dilepidid cestode. We then characterized bacteriota amphipod parasites, looking for correlations between bacterial taxa found large colours, weak support direct impact on hosts. Conversely, most interestingly, parasite’s was more strongly correlated potential amphipod-associated bacteria well. Some have synthesize pigments, propose they interact determination amphipods. This study provides correlational an association evolution host–parasite interactions generally.

Language: Английский

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Microbiota Dynamics During Ascaris suum Larval Migration: Implications for Host Microbial Communities in a Murine Model

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 198, P. 107122 - 107122

Published: Nov. 14, 2024

Language: Английский

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Form and Function in the Digenea, with an Emphasis on Host–Parasite and Parasite–Bacteria Interactions

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 3 - 45

Published: Jan. 1, 2024

Language: Английский

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What shapes a microbiome? Differences in bacterial communities associated with helminth-amphipod interactions

International Journal for Parasitology, Journal Year: 2024, Volume and Issue: 54(14), P. 733 - 742

Published: Aug. 30, 2024

The fast technological advances of molecular tools have enabled us to uncover a new dimension hidden within parasites and their hosts: microbiomes. Increasingly, parasitologists characterise host microbiome changes in the face parasitic infections, revealing potential these microscopic fast-evolving entities influence host-parasite interactions. However, most microbiomes seem depend on parasite species question. Furthermore, we should understand relative role infections as modulators when compared with other microbiome-impacting factors (e.g., size, age, sex). Here, characterised single intermediate infected by two belonging different phyla: acanthocephalan Plagiorhynchus allisonae dilepidid cestode, both infecting Transorchestia serrulata amphipods collected simultaneously from same locality. We used v4 hypervariable region 16S rRNA prokaryotic gene identify hemolymph bacterial community uninfected, acanthocephalan-infected, cestode-infected amphipods, well bacteria amphipods' immediate environment them. Our results show that were more strongly associated differences richness than amphipod presence eggs female even load. Amphipods acanthocephalans had divergent community, marked decrease alpha diversity uninfected hosts. In accordance species-specific nature found unique microbial taxa associating hosts each species, only shared between there some detected all parasitised (regardless species), but not or environment. propose distantly related helminths may be important either helping defences parasites' success, could thus interact evolution.

Language: Английский

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