Reassessing Schistosoma worms: the overlooked role in host pathology and disease elimination DOI Creative Commons
Haoran Zhong, Zhiqiang Fu, Jinming Liu

et al.

Infectious Diseases of Poverty, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 26, 2025

Abstract Background Schistosomiasis, a neglected tropical disease, remains pressing global health challenge, hindering progress toward achievement of the Sustainable Development Goals (SDGs) in endemic regions. Despite advances control strategies, including preventive chemotherapy and integrated measures, elimination schistosomiasis an elusive goal. Current understanding pathogenesis has largely focused on egg-induced pathology, while contributions schistosome worms to disease progression are relatively underexplored. The objective this article is highlight critical, yet overlooked, role advocate for broader research focus their direct impact host pathology efforts towards elimination. Main text Single-sex infections, which may occur low-transmission areas, deserve greater attention as they evade traditional egg-based diagnostics. These infections also provide valuable model explore pathology. Recent studies suggest that worms, via excretory-secretory products (ESPs), contribute liver inflammation, fibrosis, immune modulation independent egg deposition. Understanding interactions between hosts essential elucidating progression. Furthermore, potential similarities ESPs those carcinogenic trematodes need further investigation into long-term Conclusions Expanding include advancing diagnostic therapeutic strategies. By incorporating single-sex infection models targeting worm-derived molecules, it possible uncover overlooked aspects pathogenesis, improve accuracy, support efforts, thereby contributing realization SDGs. Graphical

Language: Английский

Reassessing Schistosoma worms: the overlooked role in host pathology and disease elimination DOI Creative Commons
Haoran Zhong, Zhiqiang Fu, Jinming Liu

et al.

Infectious Diseases of Poverty, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 26, 2025

Abstract Background Schistosomiasis, a neglected tropical disease, remains pressing global health challenge, hindering progress toward achievement of the Sustainable Development Goals (SDGs) in endemic regions. Despite advances control strategies, including preventive chemotherapy and integrated measures, elimination schistosomiasis an elusive goal. Current understanding pathogenesis has largely focused on egg-induced pathology, while contributions schistosome worms to disease progression are relatively underexplored. The objective this article is highlight critical, yet overlooked, role advocate for broader research focus their direct impact host pathology efforts towards elimination. Main text Single-sex infections, which may occur low-transmission areas, deserve greater attention as they evade traditional egg-based diagnostics. These infections also provide valuable model explore pathology. Recent studies suggest that worms, via excretory-secretory products (ESPs), contribute liver inflammation, fibrosis, immune modulation independent egg deposition. Understanding interactions between hosts essential elucidating progression. Furthermore, potential similarities ESPs those carcinogenic trematodes need further investigation into long-term Conclusions Expanding include advancing diagnostic therapeutic strategies. By incorporating single-sex infection models targeting worm-derived molecules, it possible uncover overlooked aspects pathogenesis, improve accuracy, support efforts, thereby contributing realization SDGs. Graphical

Language: Английский

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