Fatigue after COVID‐19 in non‐hospitalized patients according to sex

Brain and Behavior, Journal Year: 2023, Volume and Issue: 13(2)

Published: Jan. 9, 2023

Abstract Background Limited evidence exists on sex differences in post‐COVID fatigue among non‐hospitalized patients. Therefore, aim of the study was to evaluate course chronic symptoms subjects with SARS‐CoV‐2 infection, according sex. Methods Patients and staff from University Hospital Krakow anonymously retrospectively completed neuropsychological questionnaire that included eight syndrome. The presence these assessed before COVID‐19 0–4, 4–12, >12 weeks postinfection. inclusion criteria were as follows: age 18 or more years, since onset diagnosis confirmed by RT‐PCR anasopharyngeal swab. Results We 303 patients (79.53% women, 47.52% medical personnel) after a median 30 (interquartile range: 23–35) symptoms. A higher prevalence at least one symptom found females all time intervals compared males ( p < .036). Women, men, often experienced persistent fatigue, not caused effort persisting rest (for <4 weeks, odds ratio [OR] = 2.31, 95% confidence interval [CI]: 1.13–4.73; for 4–12 OR 1.95, CI: 1.06–3.61), non‐restorative sleep 2.17, 1.23–3.81; 1.03–3.71), sore throat 1.97, 1.03–3.78; 2.76, 1.05–7.27). Sex headache, arthralgia, prolonged postexercise observed only during first 4 (OR 2.59, 1.45–4.60, 2.97, 1.02–8.64, 1.87, 1.01–3.51, respectively). There no between women men myalgia self‐reported lymph node enlargement. Conclusions differs significantly sexes individuals COVID‐19, suffering rest, sleep, throat.

Language: Английский

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The determinants of COVID-induced brain dysfunctions after SARS-CoV-2 infection in hospitalized patients

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 8, 2024

The severity of the pandemic and its consequences on health social care systems were quite diverse devastating. COVID-19 was associated with an increased risk neurological neuropsychiatric disorders after SARS-CoV-2 infection. We did a cross-sectional study 3 months post-COVID 178 Cuban subjects. Our has unique CUBAN cohort hospitalized patients healthy constructed latent variable for pre-health conditions (PHC) through Item Response Theory (IRT) symptoms (Post-COVID-NPS) Factor Analysis (FA). There seems to be potential causal relationship between determinants CIBD post-COVID-NPS in patients. relationships accessed by Structural Equation Modeling (SEM) revealed that PHC (

Language: Английский

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Exploring the Relationship Between Lifestyle and Post-COVID Psychiatric Symptoms: Findings from a Brazilian Cohort

American Journal of Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Understanding how lifestyle factors impact psychiatric well-being is essential for supporting recovery in COVID-19 survivors, yet their influence on long-term outcomes remains underexplored. This cross-sectional study evaluates associations between depression, generalized anxiety disorder (GAD), post-traumatic stress (PTSD), suicidal ideation (SI), and syndromic common mental (CMD) with 730 moderate to severe survivors. Lifestyle included physical activity, alcohol substance use during infection, dietary intake, assessments conducted 6 11 months post-hospitalization. Multiple logistic regression was employed each of the five dependent variables. Of participants, 51.9% were male, a mean age 55. Previous sedative severity correlated increased depression (sedative, OR = 2.43, P .011; 1.09, .017), GAD 2.13, .007; 1.08, .009), PTSD 2.10, .008; .004), CMD (OR 1.97, .005). Opioid linked 2.23, .042), "fruits vegetables" consumption 2-3 times/week associated lower odds 0.19, .021). No behaviors found be ideation. These results underscore importance lifestyle-specific mitigating symptoms extended period from COVID-19. particularly pertinent respect minimizing sedatives context GAD, PTSD, as well opioids intake fruits vegetables depression. findings may have substantial implications formulation strategies aimed at prevention health disorders subsequent acute viral infections.

Language: Английский

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Post-COVID-19 condition: systemic inflammation and low functional exercise capacity

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: March 14, 2024

Introduction Post-COVID-19 condition (PCC) is characterised by a plethora of symptoms, with fatigue appearing as the most frequently reported. The alterations that drive both persistent and post-acute disease newly acquired symptoms are not yet fully described. Given lack robust knowledge regarding mechanisms PCC we have examined impact inflammation in PCC, evaluating serum cytokine profile its potential involvement inducing different Methods In this cross-sectional study, recruited 227 participants who were hospitalised acute COVID-19 2020 came back for follow-up assessment 6–12 months after hospital discharge. enrolled two symptomatic groups: Self-Reported Symptoms group (SR, n = 96), did present major organ lesions, reported several debilitating such fatigue, muscle weakness, loss sense smell taste; decreased Pulmonary Function (SRPF, 54), composed individuals same described SR, plus diagnosed pulmonary lesions. A Control ( 77), minor complaints following COVID-19, was also included study. Serum levels, symptom questionnaires, physical performance tests general clinical data obtained assessment. Results SRPF presented lower IL-4 concentration compared q 0.0018) SR 0.030), IFN-α2 content 0.007). addition, higher MIP-1β 0.029). CCL11 0.012 0.001, respectively) MCP-1 levels 0.052 both) SRPF. G-CSF to 0.014). Female showed handgrip strength relation 0.0082). Male needed more time complete timed up-and-go test, men 0.0302 0.0078, respectively). Our results indicate profiles accompanied distinct inflammatory markers circulation. Of particular concern function findings, likely long-lasting consequences health quality life, found phenotypes.

Language: Английский

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Symptom Clusters in Adults with Post-COVID-19: A Cross-Sectional Survey

Clinical Nursing Research, Journal Year: 2023, Volume and Issue: 32(8), P. 1071 - 1080

Published: Aug. 11, 2023

More than 100 symptoms have been reported for post-coronavirus disease 2019 (COVID-19) and this study aimed to organize self-reported by identifying symptom clusters. We used a cross-sectional survey with convenience sample of 491 adults who experiencing prolonged COVID. A list 25 post-COVID-19 was measure the symptoms, exploratory factor analysis undertaken identify clusters people lasting 5 8 weeks 9 or longer. Six were identified each two groups, five similar across both groups: respiratory, general viral, smell/taste, cognitive cardiac, mental health. The >9-week group primarily from factors: respiratory-muscular Post-COVID-19 differ timeframes. Symptom useful in establishing coherent patterns multiple complex symptoms.

Language: Английский

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Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 27, 2024

Introduction The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration enhance quality and efficiency. Methods At FMUSP-HC academic health system, we implemented innovative flow management routines for collecting, organizing analyzing demographic data, COVID-related data biological materials from over 4,500 patients with confirmed SARS-CoV-2 hospitalized 2020 2022. This strategy was mainly planned in three areas: a database hospitalizations; setting-up multidisciplinary taskforce conduct follow-up assessments after discharge; biobank. Additionally, curated collection created within institutional digital library papers map output. Results Over course experience, possible benefits challenges this type support approach were identified discussed, leading set recommended strategies institution. Demographic clinical hospitalizations compiled including adults minority children adolescents laboratory COVID-19, covering 2020–2022, approximately 350 fields per patient. To date, been used 16 published studies. assessed 700 6 11 months hospitalization through comprehensive, in-person evaluations; database, comprising around 2000 subject, 15 publications. Furthermore, thousands blood samples collected during acute phase remain stored future investigations. more than 3,700 aliquots have ongoing investigating various aspects COVID-19. Lastly, mapping overall output revealed that between 2022 our system produced 1,394 scientific articles on Discussion Research is crucial component an effective epidemic response, preparation process should include well-defined plan sharing resources. initiatives described present paper successful aim foster large-scale Although single model may not be appropriate all contexts, open make systems efficient generate best evidence.

Language: Английский

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A Two-Year cohort study examining the impact of cytokines and chemokines on cognitive and psychiatric outcomes in Long-COVID-19 patients

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Cluster analysis identifies long COVID subtypes in belgian patients

Biology Methods and Protocols, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Abstract Severe acute respiratory syndrome coronavirus infection presents complications known as long COVID, a multisystemic organ disease which allows multidimensional analysis. This study aims to uncover clusters of COVID cases and establish their correlation with the clinical classification developed at Clinical Research Unit Brugmann University Hospital, Brussels. Such an endeavour is instrumental in customizing patient management strategies tailored unique needs each distinct group. A two-stage exploratory analysis was performed on retrospective cohort 205 patients, involving factorial mixed data, then hierarchical clustering post component The study's sample comprised 76% women, average age 44.5 years. Three forms were identified: long, persistent, post-viral syndrome. Multidimensional using demographic, clinical, biological variables identified three patients. Biological data did not provide sufficient differentiation between clusters. emphasizes importance identifying or classifying patients according predominant Long phenotypes, well forms, appear be associated pathophysiological mechanisms genetic predispositions. underscores need for further research.

Language: Английский

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Manifestações psicopatológicas e cognitivas associadas à infecção pelo vírus SARS-CoV-2

Published: May 10, 2023

Introduction: Preliminary studies with patients infected the SARS-CoV-2 virus indicate involvement of different organs and systems, including central nervous system (CNS).Changes in CNS include acute chronic manifestations involving clinical expressions psychiatric, neurological or neuropsychiatric nature.In this present thesis, our objective is to characterize psychopathological cognitive alterations after 6-11 months infection.Objectives: a.To describe infection; b.Identify baseline variables that may predict manifestations" c.To investigate association smell taste changes at d.Correlate biological infection, as measured by general blood tests cytokine panel, correlate them 6 11 after.Methods: About 700 adult individuals laboratory-confirmed diagnosis COVID-19 were evaluated.Such had several data markers collected during hospitalization, being subsequently evaluated multidisciplinary, from discharge.At time, materials again collected.This thesis deals primarily a structured psychiatric interview combined symptom assessment scales battery neuropsychological order assess cognition.Results: The results are presented 3 articles.In Article 1, which involves objectives 1 2, we found: diagnoses 'depression', 'generalized anxiety disorder' 'post-traumatic stress observed, respectively, 8%, 15.5% 13 .6% sample.Memory decline was subjectively reported 51.1% patients.Psychiatric outcomes not associated any related severity illness phase, nor psychosocial stressors illness.The article 2 refer 3, is: concomitant moderate/severe olfactory gustatory loss phase significantly worse performance word list memory task.Finally, below 4. multivariate analysis found gender, age, ethnicity, education, comorbidity, frailty physical activity cognition.Bivariate (eg, G-CSF, IFN-alpha2, IL13, IL15, IL1-RA, EL1-alpha, IL45, IL5, IL6, IL7, TNF-Beta, VEGF, C-Reactive Protein D -Dimer) follow-up cognition.However, regression (LASSO), such inflammatory cytokines did remain cognition.Conclusion: Our suggest mental disorders frequent notably depression, generalized post-traumatic disorders.In addition these, about half sample report decline.However, these findings variable disease disease.On other hand, observed chemosensory tasks.Finally, support hypothesis (both

Language: Английский

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