Treatment and long-term outcome of mental disorders: the grim picture from a quasi-epidemiological investigation in 54,826 subjects from 40 countries
Psychiatry Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 116459 - 116459
Published: March 1, 2025
Language: Английский
Unravelling the joint genetic architecture between psychiatric and insulin-related traits in the general population
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 6, 2024
Abstract
Attention-deficit/hyperactivity
disorder
(ADHD),
autism
spectrum
(ASD),
and
obsessive-compulsive
(OCD)
are
heritable
disorders
that
frequently
co-occur
with
insulin
resistance
(IR)-related
conditions.
Traditional
genetic
case-control
comparisons
challenged
by
the
extent
of
heterogeneity
comorbidity
within
across
these
In
this
study
we
step
away
from
univariate
analyses
to
let
biology
guide
us
potential
links
between
psychiatry-related
traits.
We
used
large-scale
population-based
studies
(N=
17,666-697,734)
applied
genomic
structural
equation
modeling
identify
factor
structure
best
representing
joint
architecture
symptom
scores
ADHD,
ASD,
OCD,
five
IR-related
traits:
body
mass
index
(BMI),
fasting
plasma
glucose
(FPG),
insulin,
glycated
haemoglobin
(HbA1c),
homeostatic
model
assessment
for
IR.
Subsequently
performed
multivariate
genome-wide
association
on
psychiatry-IR
related
factors
explore
associations
unravel
its
biological
basis.
Factor
indicated
a
three-factor
fitted
data
(x2(df=9)=18.79,
AIC=56.8,
CFI=0.99,
SRMR=0.068).
One
included
ADHD
traits
three
(BMI,
FPG,
HbA1c),
while
another
encompassed
OCD
HbA1c.
The
last
solely
Gene-wide
revealed
57
genes
significantly
associated
ADHD-IR
(p<
2.961e-06)
one
gene,
MTNR1B
(p=3.44e-07),
OCD/OCS-IR
factor.
Gene-set
found
neurodevelopmental
pathways.
Our
findings
suggest
shared
liability
psychiatric
symptoms
in
general
population,
offering
new
perspectives
molecular
genetics
underlying
overlap
somatic
conditions
as
well
biologically
informed
clustering
psychiatry.
Language: Английский
The Problem of Assessing the Extent of Somatic Comorbidity in Patients with Major Depressive Disorder and Bipolar Disorder: Metabolic Syndrome, Cardiovascular Diseases, and Type II Diabetes Mellitus
V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY,
Journal Year:
2024,
Volume and Issue:
58(4-2), P. 29 - 38
Published: Dec. 16, 2024
The
deleterious
impact
of
depression
on
the
course
and
outcome
somatic
illness
is
well
understood,
but
subject
how
diseases
affect
clinical
picture,
course,
prognosis
has
received
little
attention.
There
a
lack
awareness
actual
level
comorbidity
in
patients
with
depression,
as
relationship
features
disease,
patient
age,
sex,
diagnostic
variants
depression.
Metabolic
syndrome
(MS),
cardiovascular
(CVDs),
type
II
diabetes
(T2D)
are
most
common
comorbidities,
causing
significant
impairment
contributing
to
mortality
rates.
All
these
closely
related
through
shared
pathophysiologic
mechanisms
neuro-immuno-metabolic
cardio-metabolic
nature.
Inflammatory
processes
genetic
risk
factors
play
crucial
role
realization
mechanisms.
Objective:
aim
this
study
analyze
existent
knowledge
prevalence
MS,
CVDs,
T2D
major
depressive
disorder
(MDD)
bipolar
(BD)
comparative
aspect,
taking
into
account
possible
effects
sex
age.
Additionally,
we
strive
highlight
specific
comorbid
patients.
Methods:
We
conducted
literature
review
topic
MDD
BD
T2D.
mostly
selected
meta-analyses
prospective
studies
large
samples.
Results:
According
current
research,
MS
affects
an
average
30-35%
individuals
both
MDD,
minor
predominance
male
CVDs
detected
18-20%
25-45%
also
slight
8-10%
people
no
gender
differences.
consistent
identifiable
signs
that
distinguish
from
non-comorbid
for
either
or
MDD.
Conclusion:
More
research
chronic
required,
particularly
given
scarcity
scientific
data
Russian
population.
Language: Английский