Genomic Testing of Clark's Theory of the British Industrial Revolution: A Note on Statistical Accuracy and Power

Published: Feb. 28, 2025

Clark[1][2] hypothesizes that the British Industrial Revolution was partly caused by a gradual evolution in frequency distribution of genetic variants associated with intelligence and related phenotypes within population. Clark's theory can be tested rigorously examining time-series trend average polygenic index scores on intelligence-related phenotypes, using genotyped DNA from human skeletal remains. This note discusses various statistical methods for such study uses Monte Carlo simulation to evaluate power estimation accuracy feasible sample sizes.

Language: Английский

Genomic Testing of Clark's Theory of the British Industrial Revolution: A Monte Carlo Analysis of Statistical Feasibility

Published: April 12, 2025

Clark[1][2] hypothesizes that the British Industrial Revolution was partly caused by a gradual evolution in frequency distribution of genetic variants associated with income-related psychosocial phenotypes. Clark's theory could be tested examining time-series trend average polygenic index scores on one or more relevant phenotypes using genotyped DNA from human skeletal remains. This note uses Monte Carlo simulation to evaluate statistical power such test for hypothetical database feasible size. I conclude building sufficient genomic Clark’s is well within capabilities current paleogenomic technology.

Language: Английский