Dyes and Pigments, Journal Year: 2024, Volume and Issue: 223, P. 111951 - 111951
Published: Jan. 6, 2024
Language: Английский
Polymer Chemistry, Journal Year: 2025, Volume and Issue: 16(8), P. 947 - 953
Published: Jan. 1, 2025
Light and fuel responsive polymers were developed. Transient hydrogels could be formed only after exposure to both photochemical stimuli.
Language: Английский
Citations
0
ChemSystemsChem, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract RNA is an information‐carrying molecule that instructs protein synthesis, but it also functions as a catalyst in so‐called ribozymes. Here, we study this multifunctional character using dynamic combinatorial library powered by chemical fuel. On the one hand, demonstrate templates oligomerization and inhibits deoligomerization. other show can be structural element formation of hydrogels. Moreover, its hydrogel, degradation nucleases accelerated. Thus, have role beyond blueprints, protectors, selectors. Template‐oligomer interactions create new (micro)environments might affect evolutionary dynamics.
Language: Английский
Citations
0
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Systems that change properties upon exposure to chemical stimuli offer the interesting prospect of (partially) mimicking functions living systems. Over past decade, numerous supramolecular systems whose composition and are regulated by dissipation fuels have been reported. These typically based on transient transformation a "dormant" species into an active, self-assembling monomer. The process is powered fuel consumption terminates depletion, restoring initial dormant state. Previously reported out-of-equilibrium polymerizations relied activation adding or removing small structural units enable polymerization. Here, we present approach combines reversibility dynamic covalent chemistry trigger "recycling" components combinatorial library (DCL). Treatment equilibrated DCL aliphatic imines aromatic amines with activated carboxylic acid (ACA) generates dissipative protonated amines. acidic conditions creation polymer held together interactions between crown ether moieties embedded in scaffold imines. Thus, reshuffles connectivity enables temporary purely (polymeric) system polymer. We demonstrate strategy using two different feedstocks consisting diimine macrocycle involving calix[4]arene distribution imine (cyclo)oligomers derived from isophthalaldehyde skeleton.
Language: Английский
Citations
0
Science and Technology of Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 22, 2025
Language: Английский
Citations
0
CCS Chemistry, Journal Year: 2023, Volume and Issue: 6(1), P. 69 - 90
Published: Sept. 27, 2023
Oligopeptide self-assembly materials have emerged as a promising class of biomaterials with diverse applications in biomedicine.This review highlights the recent progress comprehending selfassembly mechanisms intrinsic to oligopeptides and their behavior response specific stimuli.By methodically structuring amino acid sequence managing external stimuli such pH levels, redox conditions, or enzymatic activity, we can exercise unprecedented control over process.By controlling process oligopeptides, various structures extraordinary versatility be obtained, including micelles, nanofibers, coacervate droplets, each possessing modifiable mechanical chemical properties.Furthermore, these self-assembled constructs demonstrate immense potential within varied biomedical applications.The stimuli-sensitive nature oligopeptide assembly facilitates timely encapsulation release therapeutic cargos, consequently eliciting desired cellular responses.This approach paves way for more precise tumor targeting, personalized medicinal treatments, well-regulated drug dispensation.Their innate biocompatibility proficiency replicating extracellular matrix (ECM) render them ideally suited tissue engineering, wound remediation, regenerative medicine.In summary, self-assembling show tremendous adaptable platforms cutting-edge applications, thereby bridging divide between fundamental research practical clinical application.
Language: Английский
Citations
8
Chemical Communications, Journal Year: 2023, Volume and Issue: 59(96), P. 14236 - 14248
Published: Jan. 1, 2023
This Feature Article summarizes the recent advances in chemical reaction mediated supramolecular hydrogels and provides perspectives for further advances.
Language: Английский
Citations
7
Published: Jan. 17, 2024
Spontaneous chemical reactions proceed energetically downhill to either a local or global minimum, limiting possible transformations those that are exergonic. Endergonic do not spontaneously and require an input of energy. Light has been used drive number deracemisations thermodynamically unfavourable bond-forming reactions, but is restricted substrates can absorb, directly indirectly, energy provided by photons. In contrast, anabolism involves uphill powered fuels. Here we report on the transduction from artificial fuel Diels–Alder reaction. Carboxylic acid catalysed carbodiimide-to-urea formation chemically orthogonal reaction diene dienophile, transiently brings functional groups into close proximity, causing otherwise prohibited cycloaddition in modest yield (15% after two fuelling cycles) with high levels regio- (>99%) stereoselectivity (92:8 exo:endo). Kinetic asymmetry cycle ratchets away equilibrium distribution Diels–Alder:retro-Diels–Alder products. The driving endergonic occurs through ratchet mechanism (an information ratchet, depending synthetic protocol), reminiscent how molecular machines directionally bias motion. Ratcheting synthesis potential expand chemistry toolbox, offering new paradigms reactivity, complexity control.
Language: Английский
Citations
2
Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(37)
Published: April 8, 2024
A well-behaved dynamic library composed of two imines and corresponding amines was subjected to the action an activated carboxylic acid (ACA), whose decarboxylation is known be base promoted, in different solvents, namely CD
Language: Английский
Citations
2
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 27, 2024
Division is crucial for replicating biological compartments and, by extension, a fundamental aspect of life. Current studies highlight the importance simple vesicular structures in prebiotic conditions, yet mechanisms behind their self-division remain poorly understood. Recent research suggests that environmental factors can induce phase transitions fatty acid-based protocells, leading to vesicle fission. However, using chemical energy division, similar extant life, has been less explored. This study investigates mechanism division membrane budding driven without complex molecular machinery. We demonstrate that, response fuel, vesicles bud off smaller daughter vesicles. The finely controlled adjusting fuel concentration, offering valuable insights into primitive cellular dynamics. showcase robustness across different acids, retaining encapsulated materials during and suggesting protocell-like behavior. These results underscore potential drive autonomous replication protocell models, highlighting plausible pathway emergence Furthermore, this contributes development synthetic cells, enhancing our understanding minimal requirements life providing foundation future biology origins
Language: Английский
Citations
2
Chemical Science, Journal Year: 2023, Volume and Issue: 15(2), P. 431 - 441
Published: Dec. 11, 2023
Platinum's recent evolution spans from responsive complexes to multicomponent assemblies. This Perspective Article explores the role of this metal in designing macrocycles and polymers that reshape or restructure response external stimuli.
Language: Английский
Citations
6