Fusogenic Lipid Nanovesicles as Multifunctional Immunomodulatory Platforms for Precision Solid Tumor Therapy DOI
Ou Xu, Jiaxin Zhou,

Hai‐Yan Xie

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Abstract Although immunotherapy demonstrates considerable prospect in overcoming solid tumors, its clinical efficacy is limited by several factors, such as poor tumor immunogenicity, inadequate immune activation, and immunosuppressive microenvironment (TME). To overcome these challenges, a versatile universal modulation platform should be developed, lipid nanovesicles with membrane fusion capabilities (LNV‐Fs) have attracted great attention for this purpose. By mimicking natural processes, LNV‐Fs enable the precise presentation of immunogenic components on cell membranes, effectively activating anti‐tumor surveillance. Similarly, can equip multiple functionalities autologous adoptive effector cells enhanced therapies. Additionally, function vaccines that elicit robust immunity while promoting long‐term memory. Furthermore, different powerful ability reprogramming TME been reported. Given recent advancements absence comprehensive reviews topic, analysis LNV‐F systems, including their structural classifications, mechanisms, applications cancer provided. future prospects LNV‐Fs, particular emphasis artificial intelligence‐assisted design are explored. This review intended to engage researchers from diverse interdisciplinary fields provide valuable insights advancing precision immunotherapy.

Language: Английский

Fusogenic Lipid Nanovesicles as Multifunctional Immunomodulatory Platforms for Precision Solid Tumor Therapy DOI
Ou Xu, Jiaxin Zhou,

Hai‐Yan Xie

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Abstract Although immunotherapy demonstrates considerable prospect in overcoming solid tumors, its clinical efficacy is limited by several factors, such as poor tumor immunogenicity, inadequate immune activation, and immunosuppressive microenvironment (TME). To overcome these challenges, a versatile universal modulation platform should be developed, lipid nanovesicles with membrane fusion capabilities (LNV‐Fs) have attracted great attention for this purpose. By mimicking natural processes, LNV‐Fs enable the precise presentation of immunogenic components on cell membranes, effectively activating anti‐tumor surveillance. Similarly, can equip multiple functionalities autologous adoptive effector cells enhanced therapies. Additionally, function vaccines that elicit robust immunity while promoting long‐term memory. Furthermore, different powerful ability reprogramming TME been reported. Given recent advancements absence comprehensive reviews topic, analysis LNV‐F systems, including their structural classifications, mechanisms, applications cancer provided. future prospects LNV‐Fs, particular emphasis artificial intelligence‐assisted design are explored. This review intended to engage researchers from diverse interdisciplinary fields provide valuable insights advancing precision immunotherapy.

Language: Английский

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