Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 358 - 380

Published: Sept. 14, 2022

Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area. The unique properties of nanomedicines have massive potential in solving longstanding challenges existing drugs, such as poor localization at the tumor site, high doses toxicity, recurrence, immune response. However, inadequate biocompatibility restricts their clinical translation. Therefore, advanced nanomaterials with enhanced therapeutic efficiency are highly desired to fast-track translation nanomedicines. Intrinsic nanoscale covalent organic frameworks (nCOFs), suitable size, modular pore geometry porosity, straightforward post-synthetic modification via simple transformations, make them incredibly attractive future ability COFs disintegrate slightly acidic microenvironment also gives competitive advantage targeted delivery. This review summarizes recently published applications delivery, photo-immuno therapy, sonodynamic photothermal chemotherapy, pyroptosis, combination therapy. Herein we mainly focused on modifications enhance biocompatibility, efficacy will provide fundamental knowledge designing biocompatible nCOFs-based help rapid development carriers theranostics.

Language: Английский

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Linker length-dependent photocatalytic activity of β-ketoenamine covalent organic frameworks

Applied Catalysis B Environment and Energy, Journal Year: 2022, Volume and Issue: 322, P. 122135 - 122135

Published: Nov. 1, 2022

Language: Английский

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Vinylene-linked covalent organic frameworks with manipulated electronic structures for efficient solar-driven photocatalytic hydrogen production

CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION), Journal Year: 2023, Volume and Issue: 47, P. 171 - 180

Published: March 21, 2023

Language: Английский

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Recent Progress on Phase Engineering of Nanomaterials

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(23), P. 13489 - 13692

Published: Nov. 14, 2023

As a key structural parameter, phase depicts the arrangement of atoms in materials. Normally, nanomaterial exists its thermodynamically stable crystal phase. With development nanotechnology, nanomaterials with unconventional phases, which rarely exist their bulk counterparts, or amorphous have been prepared using carefully controlled reaction conditions. Together these methods are beginning to enable engineering (PEN), i.e., synthesis phases and transformation between different obtain desired properties functions. This Review summarizes research progress field PEN. First, we present representative strategies for direct modulation diverse kinds nanomaterials. We cover ranging from metal nanostructures such as Au, Ag, Cu, Pd, Ru, alloys; oxides, borides, carbides; transition dichalcogenides (TMDs) 2D layered review growth wet-chemical reduction seed-mediated epitaxial chemical vapor deposition (CVD), high pressure transformation, electron ion-beam irradiation. After that, summarize significant influence on various unconventional-phase also discuss potential applications developed areas including catalysis, electrochemical energy storage (batteries supercapacitors), solar cells, optoelectronics, sensing. Finally, existing challenges future directions

Language: Английский

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From Supramolecular Organic Cages to Porous Covalent Organic Frameworks for Enhancing Iodine Adsorption Capability by Fully Exposed Nitrogen‐Rich Sites

Small, Journal Year: 2023, Volume and Issue: 19(34)

Published: May 10, 2023

In order to overcome the limitations of supramolecular organic cages for their incomplete accessibility active sites in solid state and uneasy recyclability liquid solution, herein a nitrogen-rich cage is rationally linked into framework systems four isoreticular covalent frameworks (COFs), that is, Cage-TFB-COF, Cage-NTBA-COF, Cage-TFPB-COF, Cage-TFPT-COF, are successfully synthesized. Structure determination reveals they all high-quality crystalline materials derived from eclipsed packing related two-dimensional frameworks. Since usually have high affinity toward iodine species, adsorption investigations carried out results show them display an enhancement capacities. Especially, Cage-NTBA-COF exhibits capacity 304 wt%, 14-fold higher than sample packed itself. The strong interactions between adsorbed species revealed by spectral analyses. This work demonstrates that, utilizing reticular chemistry strategy extend close-packed porous solids, inherent properties can be greatly exploited targeted applications.

Language: Английский

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Advances in COFs for energy storage devices: Harnessing the potential of covalent organic framework materials

Energy storage materials, Journal Year: 2023, Volume and Issue: 63, P. 103014 - 103014

Published: Oct. 7, 2023

Language: Английский

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Non‐Interpenetrated 3D Covalent Organic Framework with Dia Topology for Au Ions Capture

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(33)

Published: April 23, 2023

Abstract The 3D covalent organic frameworks (COFs) have attracted considerable attention owing to their unique structural characteristics. However, most of COFs interpenetration phenomena, which will result in decreased surface area and porosities, thus limited applications molecular/gas capture. Developing with non‐fold is challenging but significant because the existence non‐covalent interactions between adjacent nets. Herein, a new COF (BMTA‐TFPM‐COF) dia topology for Au ion capture first demonstrated. constructed exhibits high Brunauer–Emmett–Teller 1924 m 2 g −1 , pore volume 1.85 cm 3 . abundant cavities as well exposed CN linkages due non‐interpenetration enable absorb 3+ capacity (570.18 mg ), selectivity (99.5%), efficiency (68.3% adsorption maximum 5 min). This work provides strategy design

Language: Английский

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Oxygen-tolerant CO2 electroreduction over covalent organic frameworks via photoswitching control oxygen passivation strategy

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 17, 2024

Abstract The direct use of flue gas for the electrochemical CO 2 reduction reaction is desirable but severely limited by thermodynamically favorable oxygen reaction. Herein, a photonicswitching unit 1,2-Bis(5’-formyl-2’-methylthien-3’-yl)cyclopentene (DAE) integrated into cobalt porphyrin-based covalent organic framework highly efficient electrocatalysis under aerobic environment. DAE moiety in material can reversibly modulate O activation capacity and electronic conductivity ring-closing/opening reactions UV/Vis irradiation. DAE-based with ring-closing type shows high Faradaic efficiency 90.5% partial current density −20.1 mA cm −2 at −1.0 V vs. reversible hydrogen electrode co-feeding 5% . This work presents an passivation strategy to realize electroreduction performance , which would inspire design electrocatalysts practical source such as from power plants or air.

Language: Английский

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Transformation of an Imine Cage to a Covalent Organic Framework Film at the Liquid–Liquid Interface

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(23)

Published: March 13, 2023

Dynamic covalent chemistry (DCC) opens up a fascinating route for the construction of well-organized supramolecular architectures, starting from organic molecular cages to crystalline macromolecular frameworks (COFs). Herein, first time, we have manifested facile room-temperature DCC-directed transformation discrete imine cage-to-COF film at liquid-liquid interface. The unfolding cage leading generation intermediates, followed by their interface-assisted preorganization and subsequent growth COF film, are elucidated through detailed spectroscopic microscopic investigations. interfacial provides faster fabrication free-standing films with high porosity crystallinity, demonstrating excellent performance towards sieving solvent permeance. Thus, current study new structural interconversion between two entities diverse dimensionality employing DCC confined

Language: Английский

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Covalent organic frameworks as electrode materials for rechargeable metal‐ion batteries

Interdisciplinary materials, Journal Year: 2023, Volume and Issue: 2(2), P. 231 - 259

Published: Feb. 9, 2023

Abstract Covalent organic frameworks (COFs), as a class of crystalline porous polymers, featuring designable structures, tunable frameworks, well‐defined channels, and tailorable functionalities, have emerged promising electrode materials for rechargeable metal‐ion batteries in recent years. Tremendous efforts been devoted to improving the electrochemical performance COFs. However, although significant achievements made, behaviors developed COFs are far away from desirable practical owing intrinsic problems, such poor electronic conductivity, trade‐off relationship between capacity redox potential, unfavorable micromorphology. In this review, progress development is presented, including Li, Na, K, Zn ion batteries. Various research strategies summarized terms molecular‐level design material‐level modification. Finally, major challenges perspectives also discussed aspect large‐scale production improvements.

Language: Английский

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