Transition-metal-free isofunctional reaction of α,β-unsaturated ketones/nitriles DOI

Runyou Ye,

Jialin Ming,

Qinyue Tao

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Language: Английский

Recent Advances in Electrochemical Carboxylation with CO2 DOI

Guo‐Quan Sun,

Li‐Li Liao,

Chuan‐Kun Ran

et al.

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(18), P. 2728 - 2745

Published: Sept. 3, 2024

ConspectusCarbon dioxide (CO

Citations

36
Aromatization-driven deconstructive functionalization of spiro dihydroquinazolinones via dual photoredox/nickel catalysis DOI Creative Commons

Hong-Jie Miao,

Jinhua Zhang, Wenke Li

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(23), P. 8993 - 8999

Published: Jan. 1, 2024

The aromatization-driven deconstructive coupling of spiro carbocycles with organic halides via dual photoredox/nickel catalysis is developed. An in-depth mechanism study revealed that this reaction proceeded a radical-metal crossover pathway.

Language: Английский

Citations

16
DFT study on isothiourea-catalyzed C–C bond activation of cyclobutenone: the role of the catalyst and the origin of stereoselectivity DOI

D.C. Li,

Yang Wang

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(13), P. 2662 - 2669

Published: Jan. 1, 2024

The mechanism of organocatalytic C-C bond activation have been theoretically investigated.

Language: Английский

Citations

9
Deacylative arylation and alkynylation of unstrained ketones DOI Creative Commons
B. L. Zhang,

Hui Bai,

Bei‐Bei Zhan

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(17)

Published: April 26, 2024

Ketones are ubiquitous in bioactive natural products, pharmaceuticals, chemical feedstocks, and synthetic intermediates. Hence, deacylative coupling reactions enable the versatile elaboration of a plethora chemicals to access complex drug candidates products. Here, we present arylation alkynylation strategies for synthesis wide range alkyl-tethered arenes alkynes from cyclic ketones methyl under dual nickel/photoredox catalysis. This reaction begins by generating pre-aromatic intermediate (PAI) through condensation ketone

Language: Английский

Citations

9
High‐Valent Copper Catalysis Enables Regioselective Fluoroarylation of Gem‐Difluorinated Cyclopropanes DOI Creative Commons
Xiuli Wu,

Xiangyu Song,

Ying Xia

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(18)

Published: March 9, 2024

Abstract Transition‐metal (TM) catalyzed reaction of gem ‐difluorinated cyclopropanes ( ‐DFCPs) has drawn much attention recently. The generally occurs via the activation distal C─C bond in ‐DFCPs by a low‐valent TM through oxidative addition, eventually producing mono‐fluoro olefins as coupling products. However, achieving regioselective proximal that overcomes intrinsic reactivity catalysis remains elusive. Here, new mode enabled high‐valent copper catalysis, which allows exclusive congested is presented. achieves fluoroarylation uses NFSI (N‐fluorobenzenesulfonimide) electrophilic fluoro reagent and arenes C─H nucleophiles, enabling synthesis diverse CF 3 ‐containing scaffolds. It proposed species plays an important role possibly σ‐bond metathesis.

Language: Английский

Citations

6
Condition-Controlled Divergent Selective Synthesis of (Z)-N-Vinyl and N-Allenyl Benzimidazoles by Pd- or Bi-Catalyzed Direct N-Alkenylation Reactions DOI

Guodong Shen,

Kun Bi,

Dehe Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

We have developed a condition-controlled divergent synthesis of (Z)-N-vinyl and N-allenyl benzimidazoles from 1,1,3-triphenylprop-2-yn-1-ols through Pd- or Bi-catalyzed N-alkenylation reactions involving nucleophilic attack C-C bond cleavage processes. The desired two different kinds products can be conveniently selectively synthesized by using this strategy, which features stereospecific synthesis, good functional group tolerance, broad substrate scope, high efficiency. strategy provides significant advantages for the biologically pharmaceutically active imidazoheterocycles.

Language: Английский

Citations

0
Electrochemical Borylation of C−C and C−Het Bonds DOI Creative Commons
T. Cheung, Hairong Lyu

ChemElectroChem, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Recently, electrochemical methods have been harnessed as a transition metal‐free strategy for borylation reactions in the synthesis of organoboron compounds. This article reviews C−C and C−Het bonds, offering systematic discussion C−C, C−N, C−O, C−S bond reactions. These transformations are applied to substrates including ammonium salts, aryl azo sulfones, carboxylic acids, arylhydrazines, nitroarenes, alcohols, thioethers, showcasing broad compatibility. Additionally, review discusses reaction mechanisms, scalability, practical applications these strategies. The concludes by outlining future research directions reactions, aiming at expending their incorporating boron into wider array organic compounds, challenging unactivated C−F borylations.

Language: Английский

Citations

0
Palladium-catalyzed carbon–carbon bond cleavage of primary alcohols: decarbonylative coupling of acetylenic aldehydes with haloarenes DOI Creative Commons

Zewei Jin,

Qiang Li, Maoshuai Zhu

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(10), P. 7826 - 7831

Published: Jan. 1, 2025

We report a novel method for the palladium-catalyzed cleavage of C–C bonds in primary alcohols, thereby enabling new route synthesis diarylacetylenes.

Language: Английский

Citations

0
Syntheses, molecular structures and properties of (Ph4P)2[trans-O2RuCl4]·CH2Cl2 and [(Ph3P)2N]2[trans-O2RuCl4]·CH2Cl2 DOI

Zhi-Cui Zhang,

Yan-Ping Jiao,

Dandan Lu

et al.

Zeitschrift für Naturforschung B, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract The two trans -Ru VI complexes, (Ph 4 P) 2 [ -O RuCl ]·CH Cl ( 1 ) and [(Ph 3 N] ), were obtained in high yields by direct oxidation of ·3H O with NaIO , followed treatment KOH cation exchange reactions. crystal structures the complexes determined single X-ray diffraction. Complexes both crystallize triclinic space groups P 1 ‾ $\overline{1}$ a = 9.9766(16), b 11.0566(18), c 12.566(2) Å, α 69.354(2), β 77.228(2), γ 82.328(2)°, Z for complex 10.897(3), 12.402(4), 14.449(5) 110.395(4), 91.853(4), 98.500(4)°, . characterized FT-IR, H NMR, 31 P{H} UV/Visible spectroscopies, their electrochemical properties also investigated.

Language: Английский

Citations

0
Pd-Catalyzed Aerobic C–H Carbonylative Esterification of Imidazo[1,2-a]pyridines with Alcohols as the Carbonyl Source DOI
Jianguo Sun, He’an Luo, Junyong Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

A simple and practical method has been developed for the carbonylative esterification of imidazo[1,2-a]pyridines via C(sp2)-H bond functionalization using alkyl alcohols under mild reaction conditions. The carbonyl fragment is sourced from radical-mediated C-C cleavage alcohols, providing a green, safe, economic alternative to traditional sources like carbon monoxide. Through this strategy, number imidazo[1,2-a]pyridine-3-carboxylates were obtained substrates by single step.

Language: Английский

Citations

0