Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: Aug. 16, 2024

Abstract Bioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological processes in living systems. As the great advancement of nanotechnology recent years, bioorthogonal nanozymes are innovated tackle challenges that emerged practical biomedical applications. uniquely positioned owing their advantages high customizability and tunability, as well good adaptability systems, which bring exciting opportunities for More intriguingly, offers opportunity innovating catalytic materials. In this comprehensive review, significant progresses discussed with both spatiotemporal controllability performance highlight design principles rapid The remaining future perspectives then outlined along thriving field. It is expected review will inspire promote novel nanozymes, facilitate clinical translation.

Language: Английский

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In-situ activation of biomimetic single-site bioorthogonal nanozyme for tumor-specific combination therapy

Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122755 - 122755

Published: Aug. 13, 2024

Language: Английский

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Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Bioorthogonal catalysis has revolutionized the field of chemical biology by enabling selective and controlled transformations within living systems. Research converged on development innovative catalyst scaffolds, seeking to broaden scope bioorthogonal reactions, boost their efficiency, surpass limitations conventional catalysts. This review provides a comprehensive overview latest advancements in research based different scaffold materials. Through an in-depth analysis fabrication strategies applications catalysts, this discusses design principles, mechanisms action, these novel catalysts biology. Current challenges future directions exploring diversity are also highlighted. The integration diverse scaffolds offers exciting prospects for precise manipulation biomolecules therapeutic In addition, fills gaps previous reviews, such as fully summarizing presented materials applied emphasizing potential impact advancing chemistry, offering field.

Language: Английский

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Light-Triggered Bioorthogonal Nanozyme Hydrogels for Prodrug Activation and Treatment of Bacterial Biofilms

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Bioorthogonal nanozymes offer in situ activation of pro-dyes and prodrugs using abiotic chemical transformations. Bacterial infections, especially biofilm-associated are extremely difficult to treat due obstacles such as poor antibiotic penetration the rising threat resistance. Spatiotemporal control bioorthogonal catalysis provides a strategy for "on-demand" generation therapeutics, effectively localizing therapeutic action minimizing side effects. Here, we present fabrication visible-light-responsive alginate hydrogel beads embedded with polyzymes (PZs). Exposure 405 nm light induces reduction Fe(III) Fe(II), triggering dissolution PZ-gel concomitant release polyzyme. This approach enabled selective prodrug Linezolid, last-in-line Gram-positive bacterial enabling targeted eradication multidrug-resistantStaphylococcus aureus biofilms. Overall, use biomaterial along noninvasive visible offers nontoxic platform spatiotemporal antibiotics through activation.

Language: Английский

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An Innovative and Efficient Low Temperature Hydrothermal-Calcination Process for β-FeOOH Nanorods and Hollow-Structure α-Fe2O3 Magnetic Nanorods Exclusively Utilizing FeCl3 in an Alcohol-Containing Aqueous Solution

Materials, Journal Year: 2025, Volume and Issue: 18(9), P. 2079 - 2079

Published: May 1, 2025

A facile low temperature hydrothermal-calcination approach was developed for the fabrication of β-FeOOH nanorods (NRs) and hollow-structure α-Fe2O3 magnetic (MNRs), products were characterized using SEM, TEM, XRD VSM techniques. To achieve smaller-sized NRs, effects Fe3+ concentration, volume ratio ethanol to water in solution, hydrothermal temperature, time on structure precursors systematically investigated, with an average length 104 nm diameter 36 fabricated at 100 °C 2 h 0.15 M ferric chloride hexahydrate 50% solution. Subsequently, MNRs 67 nm, 20 thickness 5 successfully obtained via calcination process 400 2.5 versatile applications.

Language: Английский

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Chitosan nanoreactor modified with PNIPAAm as efficient catalyst for preparation of chiral boron compounds in aqueous phase

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143865 - 143865

Published: May 1, 2025

Language: Английский

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Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Innovative strategies for targeted anticancer therapies have gained significant momentum, with metal complexes emerging as tunable catalysts more effective and safer treatments. Rational design engineering of enable the development tailored molecular structures optimized precision oncology. The strategic incorporation complex within combinatorial amplifies their properties. This perspective highlights advancements in synthetic rational since 2019, showing how are by designing to release or

Language: Английский

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Solid-State Self Carbo-Passivation for Refurbishing Colloidal Dispersity of Catalytic Silica Nanoreactors

Materials Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

A self-carbo-passivation strategy tackles the agglomeration issue in silica nanostructures by thermally forming carbonaceous skin patches on nanoparticle surface.

Language: Английский

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