Continuous Flow aqueous tandem conversion of trans-ferulic acid into high added value chemicals DOI Creative Commons
Kelvin Adrian Sanoja‐López, Rafael Luque

Results in Engineering, Journal Year: 2024, Volume and Issue: unknown, P. 103827 - 103827

Published: Dec. 1, 2024

Language: Английский

Towards sustainable quantum dots: Regulatory framework, toxicity and emerging strategies DOI
Carlotta Campalani, Jean‐Christophe M. Monbaliu

Materials Science and Engineering R Reports, Journal Year: 2025, Volume and Issue: 163, P. 100940 - 100940

Published: Jan. 29, 2025

Language: Английский

Citations

1
Upscaled Synthesis of α‐ and β‐Peptides in a Continuous‐Flow Reactor Using Propylene Carbonate as an Eco‐Friendly Solvent DOI Open Access
Nikolett Varró,

Beáta Mándityné Huszka,

Eszter Erdei

et al.

Chemistry - Methods, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

A rapid, eco‐friendly, and scalable continuous‐flow solid‐phase peptide synthesis (CF‐SPPS) technology has been developed using propylene carbonate (PC) as a solvent. PC, greener alternative to DMF, is selected based on the GSK solvent selection guide. To evaluate its compatibility with CF‐SPPS, four α‐peptides were synthesized, achieving high yields purity. The method further validated challenging sequences, including β‐peptide foldamers an α/β‐peptide chimera. scale up this innovative approach, larger column geometries are optimized ensure appropriate resin load flow rate for desired residence times. demonstrated capability synthesize peptides >4 g satisfactory efficiency. key feature use of PC in minimal amounts, significantly enhancing process's green credentials. low consumption efficiency align chemistry principles, reducing waste improving sustainability. process mass intensity highlights environmental benefits, making it sustainable large‐scale synthesis. This breakthrough showcases potential CF‐SPPS meet demands more efficient production.

Language: Английский

Citations

0
Photoinduced Enantioselective Transformations via o-Quinodimethane Intermediates DOI Creative Commons
Liwen Xia, Qingqin Huang, Zhaofei Zhang

et al.

Tetrahedron Chem, Journal Year: 2025, Volume and Issue: unknown, P. 100131 - 100131

Published: April 1, 2025

Language: Английский

Citations

0
Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing DOI
Diana V. Silva-Brenes, Shailesh Agrawal, Vilmalí López-Mejías

et al.

Reaction Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 9(10), P. 2728 - 2739

Published: Jan. 1, 2024

This study reports efforts toward the integrated advanced manufacturing of anti-narcoleptic drug modafinil via flow chemistry and continuous crystallization.

Language: Английский

Citations

0
Continuous Flow aqueous tandem conversion of trans-ferulic acid into high added value chemicals DOI Creative Commons
Kelvin Adrian Sanoja‐López, Rafael Luque

Results in Engineering, Journal Year: 2024, Volume and Issue: unknown, P. 103827 - 103827

Published: Dec. 1, 2024

Language: Английский

Citations

0