Iron-Catalyzed Three-Component Reactions of Cyclopropanols with Alkenes and N-Heteroarenes via Ring-Opening and C–H Functionalization DOI
Jie Yang, Shuang Wu, Ying Chu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

An iron-catalyzed ring-opening multicomponent reaction of cyclopropyl alcohols with alkenes and N-heteroarenes involving aryl C(sp2)-H functionalization was developed. This protocol facilitates the regioselective introduction both β-carbonyl moiety an N-heteroarene group across C═C bond alkene, thus allowing a straightforward, efficient, facile access to 5-heteroarene ketones. In this process, strategy relies on alkyl radical formation from alcohols, addition bonds, heteroaryl cascades. general approach displays excellent selectivity control broad functional-group tolerance.

Language: Английский

Iron-Catalyzed Three-Component Reactions of Cyclopropanols with Alkenes and N-Heteroarenes via Ring-Opening and C–H Functionalization DOI
Jie Yang, Shuang Wu, Ying Chu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

An iron-catalyzed ring-opening multicomponent reaction of cyclopropyl alcohols with alkenes and N-heteroarenes involving aryl C(sp2)-H functionalization was developed. This protocol facilitates the regioselective introduction both β-carbonyl moiety an N-heteroarene group across C═C bond alkene, thus allowing a straightforward, efficient, facile access to 5-heteroarene ketones. In this process, strategy relies on alkyl radical formation from alcohols, addition bonds, heteroaryl cascades. general approach displays excellent selectivity control broad functional-group tolerance.

Language: Английский

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