Nanomaterials reshape the pulmonary mechanical microenvironment: novel therapeutic strategies for respiratory diseases

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 2, 2025

Respiratory diseases, including chronic obstructive pulmonary disease (COPD), idiopathic fibrosis (IPF), and lung cancer, exhibit elevated death rates pathological intricacy, requiring advancements that surpass the constraints of traditional therapies. This study comprehensively outlines novel applications nanomaterials in respiratory medicine by accurately modulating mechanical microenvironment, encompassing alveolar surface tension, extracellular matrix rigidity, immune-fibroblast interaction network. The precise delivery, stimuli-responsive characteristics, biomimetic design markedly improve drug concentration at lesion site mitigate fibrosis, inflammation, malignant tumor advancement disrupting signaling pathways. clarifies their multifaceted benefits treating COPD, IPF, decreased systemic toxicity improved spatiotemporal control. Nonetheless, clinical translation continues to encounter obstacles, impediments large-scale production, inadequate compatibility with breathing devices, disputes concerning long-term biosafety. In future, amalgamation precision medicine, adaptive smart materials, multi-omics artificial intelligence technologies will facilitate development individualized diagnostic therapeutic systems, establishing a paradigm for proactive management disorders. review offers essential theoretical foundations technical approaches practical application enhancement techniques medicine.

Language: Английский

Therapeutic Applications of Poly-miRNAs and miRNA Sponges

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4535 - 4535

Published: May 9, 2025

MicroRNAs (miRNAs) are small, non-coding RNA molecules that play crucial roles in regulating gene expression, and their dysregulation is implicated various human diseases. Over the years, several research groups have identified miRNAs as promising therapeutic targets for intervention. Therapeutic strategies involve either overexpression or knockdown of specific miRNAs. This review aims to provide a comprehensive overview synthetic poly-miRNAs miRNA sponges, highlighting applications. It begins with an introduction role diseases, followed by detailed discussion on sponges exploring application cardiovascular, inflammatory, autoimmune, metabolic disorders, well cancer therapy. Additionally, targeted delivery, challenges, limitations these therapies addressed.

Language: Английский