Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(45)
Published: June 16, 2023
Abstract
Electrochemistry
utilizes
electrons
as
a
potent,
controllable,
and
traceless
alternative
to
chemical
oxidants
or
reductants,
typically
offers
more
sustainable
option
for
achieving
selective
organic
synthesis.
Recently,
the
merger
of
electrochemistry
with
readily
available
electrophiles
has
been
recognized
viable
increasingly
popular
methodology
efficiently
constructing
challenging
C−C
C‐heteroatom
bonds
in
manner
complex
molecules.
In
this
mini‐review,
we
have
systematically
summarized
most
recent
advances
electroreductive
cross‐electrophile
coupling
(eXEC)
reactions
during
last
decade.
Our
focus
on
electrophiles,
including
aryl
alkyl
(pseudo)halides,
well
small
molecules
such
CO
2
,
SO
D
O.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 30, 2022
Abstract
Herein,
a
facile
and
general
electroreductive
deuteration
of
unactivated
alkyl
halides
(X
=
Cl,
Br,
I)
or
pseudo-halides
OMs)
using
D
2
O
as
the
economical
deuterium
source
was
reported.
In
addition
to
primary
secondary
halides,
sterically
hindered
tertiary
chlorides
also
work
very
well,
affording
target
deuterodehalogenated
products
with
excellent
efficiency
incorporation.
More
than
60
examples
are
provided,
including
late-stage
dehalogenative
natural
products,
pharmaceuticals,
their
derivatives,
all
incorporation
(up
99%
D),
demonstrating
potential
utility
developed
method
in
organic
synthesis.
Furthermore,
does
not
require
external
catalysts
tolerates
high
current,
showing
possible
use
industrial
applications.
Chemical Communications,
Journal Year:
2022,
Volume and Issue:
58(15), P. 2430 - 2442
Published: Jan. 1, 2022
The
electrocatalytic
urea
oxidation
reaction
(UOR)
has
attracted
substantial
research
interests
over
the
past
few
years
owing
to
its
critical
role
in
coupled
electrochemical
systems
for
energy
conversion,
example,
coupling
with
hydrogen
evolution
(HER)
realize
urea-assisted
production
and
assembling
direct
fuel
cells
(DUFC)
by
oxygen
reduction
(ORR).
UOR
process
been
proved
be
a
two-step
which
involves
an
pre-oxidation
of
metal
sites
subsequent
chemical
molecules
on
as-formed
high-valence
sites.
Hence,
designing
advanced
(pre-)catalysts
boosted
is
great
importance
improving
performance
thus
accelerating
reactions.
In
this
feature
article,
we
discuss
significant
during
electro-oxidation
reaction,
summarize
detailed
strategies
recent
advances
promoting
including
modulation
crystallinity,
active
phase
engineering,
defect
elemental
incorporation
constructing
hierarchical
nanostructures.
We
anticipate
that
article
will
offer
helpful
guidance
design
optimization
related
conversion
applications.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(47), P. 21674 - 21682
Published: Nov. 17, 2022
Asymmetric
sp3
C–H
functionalization
has
been
demonstrated
to
substantially
expedite
target
molecule
synthesis,
spanning
from
feedstocks
upgradation
late-stage
modification
of
complex
molecules.
Herein,
we
report
a
highly
efficient
and
sustainable
method
for
enantioselective
benzylic
cyanation
by
merging
electrophoto-
copper
catalysis.
A
novel
catalytic
system
allows
one
independently
regulate
the
hydrogen
atom
transfer
step
radical
formation
speciation
Cu(II)/Cu(I)
effectively
capture
transient
intermediate,
through
tuning
electronic
property
anthraquinone-type
photocatalyst
simply
modulating
applied
current,
respectively.
Such
decoupled
relay
catalysis
enables
unified
approach
diverse
alkylarenes,
many
which
are
much
less
reactive
or
even
unreactive
using
existing
relying
on
coupled
relay.
Moreover,
current
protocol
is
also
amenable
bioactive
molecules,
including
natural
products
drugs.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(41)
Published: Aug. 26, 2022
Herein,
an
electroreductive
carboxylation
of
organic
carbon-halogen
bonds
(X=Br
and
Cl)
promoted
by
catalytic
amounts
naphthalene
as
mediator
is
reported.
This
transformation
proceeds
smoothly
under
mild
conditions
with
a
broad
substrate
scope
59
examples,
affording
the
valuable
versatile
carboxylic
acids
in
moderate
to
excellent
yields
without
need
costly
transition
metal,
wasted
stoichiometric
metal
reductants,
or
sacrificial
anodes.
Further
late-stage
carboxylations
natural
product
drug
derivatives
demonstrate
its
synthetic
utility.
Mechanistic
studies
confirmed
activation
via
single-electron
transfer
key
role
this
reaction.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(45)
Published: June 16, 2023
Abstract
Electrochemistry
utilizes
electrons
as
a
potent,
controllable,
and
traceless
alternative
to
chemical
oxidants
or
reductants,
typically
offers
more
sustainable
option
for
achieving
selective
organic
synthesis.
Recently,
the
merger
of
electrochemistry
with
readily
available
electrophiles
has
been
recognized
viable
increasingly
popular
methodology
efficiently
constructing
challenging
C−C
C‐heteroatom
bonds
in
manner
complex
molecules.
In
this
mini‐review,
we
have
systematically
summarized
most
recent
advances
electroreductive
cross‐electrophile
coupling
(eXEC)
reactions
during
last
decade.
Our
focus
on
electrophiles,
including
aryl
alkyl
(pseudo)halides,
well
small
molecules
such
CO
2
,
SO
D
O.
