Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 454, P. 214356 - 214356

Published: Dec. 14, 2021

Language: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 476, P. 214908 - 214908

Published: Nov. 7, 2022

Language: Английский

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Recent advances and perspectives in reaction-based fluorescent probes for imaging peroxynitrite in biological systems

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 474, P. 214848 - 214848

Published: Oct. 7, 2022

Language: Английский

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An Activatable Near‐Infrared Afterglow Theranostic Prodrug with Self‐Sustainable Magnification Effect of Immunogenic Cell Death

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(40)

Published: Aug. 2, 2022

Abstract Herein, we report an activatable near‐infrared (NIR) afterglow theranostic prodrug that circumvents high background noise interference caused by external light excitation. The can release hydroxycamptothecin (HCPT) in response to the intratumoral peroxynitrite level associated with immunogenic cell death (ICD), and synchronously activate signal monitor drug process cold‐to‐hot tumor transformation. itself is ICD inducer achieved photodynamic therapy (PDT). PDT initiates recruits first‐arrived neutrophils secrete trigger HCPT release. Intriguingly, demonstrate significantly amplify PDT‐mediated process. thus shows a self‐sustainable magnification effect establishing “ICD‐HCPT release‐amplified ICD” cycling loop. In vivo studies eradicate existing tumors prevent further recurrence through antitumor immune response.

Language: Английский

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Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3916 - 3968

Published: Jan. 23, 2024

Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological pathological states. Therefore, it is crucial to design imaging systems capable real-time detection dynamic changes for accurate diagnosis effective treatment diseases. Recently, ratiometric has emerged as a widely used technique sensing due its advantage circumventing limitations inherent conventional intensity-dependent signal readout methods while also providing built-in self-calibration correction. Here, recent progress probes their applications outlined. Ratiometric classified according mechanisms, photoacoustic imaging, optical including photoluminescence self-luminescence magnetic resonance dual-modal discussed. The such pH, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, hypoxia discussed detail. Additionally, this Review presents an overview challenges faced field along future research directions.

Language: Английский

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A near-infrared fluorescent probe for ratiometric imaging peroxynitrite in Parkinson's disease model

Sensors and Actuators B Chemical, Journal Year: 2022, Volume and Issue: 359, P. 131393 - 131393

Published: Jan. 28, 2022

Language: Английский

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From Mitochondria to Atherosclerosis: The Inflammation Path

Biomedicines, Journal Year: 2021, Volume and Issue: 9(3), P. 258 - 258

Published: March 5, 2021

Inflammation is a key process in metazoan organisms due to its relevance for innate defense against infections and tissue damage. However, inflammation also implicated pathological processes such as atherosclerosis. Atherosclerosis chronic inflammatory disease of the arterial wall where unstable atherosclerotic plaque rupture causing platelet aggregation thrombosis may compromise lumen, leading acute or ischemic syndromes. In this review, we will focus on role mitochondria atherosclerosis while keeping link. Mitochondria are main source cellular energy. Under stress, capable controlling through production reactive oxygen species (ROS) release mitochondrial components, DNA (mtDNA), into cytoplasm extracellular matrix, they act danger signals when recognized by immune receptors. Primary secondary dysfunctions associated with initiation progression elevating ROS, altering dynamics energy supply, well promoting inflammation. Knowing understanding pathways behind mitochondrial-based atheroma essential discovering alternative complementary treatments.

Language: Английский

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A novel aggregation-induced emission fluorescent probe to visualize peroxynitrite levels during Golgi stress

Sensors and Actuators B Chemical, Journal Year: 2022, Volume and Issue: 358, P. 131513 - 131513

Published: Feb. 1, 2022

Language: Английский

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Construction of HClO activated near-infrared fluorescent probe for imaging hepatocellular carcinoma

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1252, P. 341009 - 341009

Published: March 1, 2023

Language: Английский

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Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications

Theranostics, Journal Year: 2023, Volume and Issue: 13(5), P. 1716 - 1744

Published: Jan. 1, 2023

Peroxynitrite (ONOO-), owing to its high oxidative and nitrating stress, is associated with several physiological processes in addition various pathological processes, including those related neurodegenerative diseases cancer. Detection of ONOO- at the cellular level great significance understand pathogenesis. To this end, a variety fluorescent probes based on small molecules nanoparticles (NPs) have been engineered applied as excellent tools for imaging cells well their diverse biological applications. In review, we highlight representative cases recognition mechanism emphasize response type (ratiometric, two-photon, long-wavelength/near-infrared, targeting) detection last five years. We further discuss design strategy, sensing mechanism, application bio-imaging describe NP-based according nanoplatforms.

Language: Английский

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