Sensitive Electrochemical Detection of Carcinoembryonic Antigen Based on Biofunctionalized Nanochannel Modified Carbonaceous Electrode

Molecules, Journal Year: 2024, Volume and Issue: 29(4), P. 858 - 858

Published: Feb. 15, 2024

The convenient construction of carbon-based electrochemical immunosensors with high performance is highly desirable for the efficient detection tumor biomarkers. In this work, an immunosensor was fabricated by integrating a biofunctionalized mesoporous silica nanochannel film electrode, which can enable sensitive determination carcinoembryonic antigen (CEA) in serum. commonly used carbonaceous glassy carbon electrode (GCE), employed as supporting and pre-treated through polarization to achieve stable binding vertically ordered amino groups (NH2-VMSF) without use any adhesive layer. To fabricate immunorecognition interface, antibodies were covalently immobilized after on outer surface NH2-VMSF derivatized aldehyde groups. presence sites within high-density nanochannels facilitate migration negatively charged redox probes (Fe(CN)63-/4-) electrostatic adsorption, leading generation signals. CEA, formation immunocomplexes recognitive interface reduce signal Fe(CN)63-/4- electrode. Based principle, CEA achieved. be determined range from 0.01 ng mL−1 100 limit 6.3 pg mL−1. exhibited selectivity, fetal bovine serum

Language: Английский

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A versatile gold leaf immunosensor with a novel surface functionalization strategy based on protein L and trastuzumab for HER2 detection

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

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In Vivo Electrochemical Biosensing Technologies for Neurochemicals: Recent Advances in Electrochemical Sensors and Devices

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

In vivo electrochemical sensing of neurotransmitters, neuromodulators, and metabolites plays a critical role in real-time monitoring various physiological or psychological processes the central nervous system. Currently, advanced biosensors technologies have been emerging as prominent ways to meet surging requirements neurotransmitters neuromodulators ranging from single cells brain slices, even entire brain. This review introduces fundamental working principles summarizes achievements biosensing including voltammetry, amperometry, potentiometry, field-effect transistor (FET), organic (OECT). According elaborate feature technology, versatile strategies devoted solve issues associated with neurochemicals under an intricate environment. Voltammetry is universal technique investigate complex matrices which could realize miniaturization electrodes, while amperometry serves well-suited approach offering high temporal resolution favorable for fast oxidation–reduction kinetics neurochemicals. Potentiometry realizes quantitative analysis by recording potential difference reduced invasiveness compatibility. FET OECT serve amplification higher sensitivity than traditional technologies. Furthermore, we point out current shortcomings address challenges perspectives

Language: Английский

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Nanomaterial based analytical methods for breast cancer biomarker detection

Materials Today Advances, Journal Year: 2022, Volume and Issue: 14, P. 100219 - 100219

Published: Feb. 16, 2022

Female breast cancer is the leading cause of global incidence and fifth mortality worldwide in 2020. Breast can be categorized into different subtypes according to expression biomarkers such as estrogen receptors (ER), progesterone (PR) human epidermal growth factor receptor 2 (HER2). The analysis these also indispensable for systemic treatment decisions cancer. In this review, we summarized recent progress detection blood utilizing nanomaterials. attractive physical, chemical, optical electronic properties various nanomaterials facilitated improved performance detection. relatively non-invasive provide useful biological information that complementary imaging examination immunohistochemistry.

Language: Английский

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Microfluidic paper-based analytical devices for cancer diagnosis

Sensors and Actuators B Chemical, Journal Year: 2022, Volume and Issue: 379, P. 133243 - 133243

Published: Dec. 28, 2022

Language: Английский

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Peptide nucleic acid and antifouling peptide based biosensor for the non-fouling detection of COVID-19 nucleic acid in saliva

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 225, P. 115101 - 115101

Published: Jan. 25, 2023

Language: Английский

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Nitrogen and fluoride co-doped graphdiyne with metal-organic framework (MOF)-derived NiCo2O4–Co3O4 nanocages as sensing layers for ultra-sensitive pesticide detection

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1252, P. 341012 - 341012

Published: March 3, 2023

Language: Английский

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Towards sense and sensitivity-based electrochemical biosensors for liquid biopsy-based breast cancer detection

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 163, P. 117050 - 117050

Published: April 6, 2023

Language: Английский

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Early detection of tumour-associated antigens: Assessment of point-of-care electrochemical immunoassays

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 160, P. 116981 - 116981

Published: Feb. 10, 2023

Language: Английский

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A Comprehensive Review on Electrochemical Nano Biosensors for Precise Detection of Blood-Based Oncomarkers in Breast Cancer

Biosensors, Journal Year: 2023, Volume and Issue: 13(4), P. 481 - 481

Published: April 16, 2023

Breast cancer (BC), one of the most common and life-threatening cancers, has highest incidence rate among women. Early diagnosis BC oncomarkers is considered effective strategy for detecting treating BC. Finding type stage in women as soon possible greatest ways to stop its negative effects on medical treatment. The development biosensors early, sensitive, selective detection recently attracted much attention. An electrochemical nano biosensor (EN) a very suitable option powerful tool diagnosis. This comprehensive review provides information about prevalence pathobiology BC, recent advances clinically available oncomarkers, point-of-care (POC) various using nanomaterial-based signal amplification techniques.

Language: Английский

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