ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(48), P. 45700 - 45707
Published: Nov. 22, 2023
This
study
showcases
the
creation
of
a
biosensor
strip
designed
for
rapid,
precise,
and
highly
sensitive
electrochemical
detection
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
These
strips
were
crafted
by
affixing
monoclonal
antibody
(mAb)
specific
to
SARS-CoV-2
onto
surface
commercially
screen-printed
carbon
electrode
(SPCE)
modified
with
polyaniline-titania
nanotubes
(PANi-TNT).
The
transportable
sensing
device
was
constructed
pairing
mAb
functionalized
portable
potentiostat
wirelessly
connected
either
Windows
or
Android
device.
Fast
conjugation
between
spike
protein
immobilized
anti-SARS-CoV-2
triggered
change
in
charge
electron
mobility
biosensing
layer
produce
detectable
current
during
chronoamperometric
scanning
presence
phosphate
buffer
solution
(PBS).
excellent
sensitivity
specificity
sensor
toward
detected
as
analytical
analysis
demonstrated
linearity
range
80
200
copies/μL
limit
25.59
from
dose-response
standard
fitted
curve.
Through
experimental
validation,
strip's
ability
specifically
detect
established,
distinguishing
it
human
coronavirus-OC43
(HCoV-OC43),
HCoV-NL63,
HCoV-229E,
adenovirus.
results
these
tests
indicate
that
possess
potential
future
dependable
easily
point-of-care
diagnostic
devices,
enabling
swift,
sensitive,
precise
saliva
nasopharyngeal
fluid
individuals
infected
virus.
Chemosensors,
Journal Year:
2022,
Volume and Issue:
10(7), P. 287 - 287
Published: July 20, 2022
Rapid
and
early
diagnosis
of
lethal
coronavirus
disease-19
(COVID-19)
caused
by
the
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
is
an
important
issue
considering
global
human
health,
economy,
education,
other
activities.
The
advancement
understanding
chemistry/biochemistry
structure
SARS-CoV-2
virus
has
led
to
development
low-cost,
efficient,
reliable
methods
for
COVID-19
over
“gold
standard”
real-time
reverse
transcription-polymerase
chain
reaction
(RT-PCR)
due
its
several
limitations.
This
electrochemical
sensors/biosensors
rapid,
fast,
low-cost
detection
from
patient’s
biological
fluids
detecting
components
virus,
including
structural
proteins
(antigens),
nucleic
acid,
antibodies
created
after
infection.
review
comprehensively
summarizes
state-of-the-art
research
progress
biosensors
diagnosis.
They
include
spike
protein,
nucleocapsid
whole
antibodies.
also
outlines
different
methods,
design
strategies
highlighting
current
challenges
future
perspectives.
Biosensors,
Journal Year:
2023,
Volume and Issue:
13(4), P. 490 - 490
Published: April 19, 2023
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
has
caused
an
ongoing
disease
(COVID-19)
outbreak
and
a
rising
demand
for
the
development
of
accurate,
timely,
cost-effective
diagnostic
tests
SARS-CoV-2
as
well
other
viral
infections
in
general.
Currently,
traditional
virus
screening
methods
such
plate
culturing
real-time
PCR
are
considered
gold
standard
with
accurate
sensitive
results.
However,
these
still
require
sophisticated
equipment,
trained
personnel,
long
analysis
time.
Alternatively,
integration
microfluidic
biosensor
technologies,
microfluidic-based
biosensors
offer
ability
to
perform
sample
preparation
simultaneous
detection
many
analyses
one
platform.
High
sensitivity,
accuracy,
portability,
low
cost,
high
throughput,
can
be
achieved
using
single
This
review
presents
recent
advances
from
works
demonstrate
advantages
merging
two
technologies
sensing
viruses.
Different
platforms
classified
into
main
sections:
immunoassays
molecular
assays.
Moreover,
available
commercial
analyzed.
The Analyst,
Journal Year:
2023,
Volume and Issue:
148(14), P. 3359 - 3370
Published: Jan. 1, 2023
A
polyaniline
functionalized
NiFeP
nanosheet
array-based
electrochemical
immunosensor
using
Au/Cu
2
O
nanocubes
as
a
signal
amplifier
is
fabricated
for
the
detection
of
SARS-CoV-2
nucleocapsid
protein
(SARS-CoV-2
NP).
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
2(1), P. 34 - 57
Published: May 10, 2023
In
December
2019,
an
outbreak
of
unknown
pneumonia
emerged
in
Wuhan
City,
Hubei
Province,
China.
It
was
later
identified
as
the
SARS-CoV-2
virus
and
has
since
infected
over
9
million
people
more
than
213
countries
worldwide.
Massive
papers
on
topic
that
have
already
been
published
are
necessary
to
be
analyzed
discussed.
This
paper
used
combination
systematic
literature
network
analysis
content
develop
a
comprehensive
discussion
related
use
nanotechnology
materials
environmental
human
protection.
Its
is
shown
various
efforts
made
control
transmission
this
pandemic.
Nanotechnology
plays
crucial
role
modern
vaccine
design,
nanomaterials
essential
tools
for
antigen
delivery,
adjuvants,
mimics
viral
structures.
addition,
also
reported
protection
defence
treating
To
eradicate
pandemics
now
future,
successful
treatments
must
enable
rapid
discovery,
scalable
manufacturing,
global
distribution.
review,
we
discuss
current
approaches
COVID-19
development
highlight
critical
combating
body
environment.
Analytica Chimica Acta,
Journal Year:
2023,
Volume and Issue:
1281, P. 341926 - 341926
Published: Oct. 17, 2023
The
outbreak
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
which
was
first
reported
in
early
January
2020,
continues
to
devastate
the
worlds
public
health
system.
Herein,
we
report
on
development
a
novel
metal-enhanced
fluorescence
(MEF)
and
electrochemical
biosensor
for
SARS-CoV-2
spike
(S)
protein.
To
develop
MEF
biosensor,
SiO
