ACS Sensors,
Journal Year:
2023,
Volume and Issue:
8(10), P. 3882 - 3891
Published: Sept. 22, 2023
Diabetic
cataract
(DC)
surgery
carries
risks
such
as
slow
wound
healing,
macular
edema,
and
progression
of
retinopathy
is
faced
with
a
deficiency
effective
drugs.
In
this
context,
we
proposed
protocol
to
evaluate
the
drug's
efficacy
using
lipid
droplets
(LDs)
marker.
For
purpose,
fluorescent
probe
PTZ-LD
for
LDs
detection
developed
based
on
phenothiazine
unit.
The
displays
polarity-dependent
emission
variations,
i.e.,
lower
polarity
leading
stronger
intensity.
Especially,
exhibits
photostability
superior
that
Nile
Red,
commercial
staining
dye.
Using
probe,
formation
in
DC-modeled
human
lens
epithelial
(HLE)
cells
validated,
interplay
LDs-LDs
LDs-others
are
investigated.
Unexpectedly,
transfer
between
visualized.
Moreover,
therapeutic
various
drugs
HLE
assessed.
Ultimately,
more
were
found
tissues
from
DC
patients
than
first
time.
We
anticipate
work
can
attract
attention
important
roles
during
progression.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(9)
Published: Jan. 10, 2024
The
concept
of
molecular
design,
integrating
diagnostic
and
therapeutic
functions,
aligns
with
the
general
trend
modern
medical
advancement.
Herein,
we
rationally
designed
smart
molecule
ER-ZS
for
endoplasmic
reticulum
(ER)-targeted
diagnosis
treatment
in
cell
animal
models
by
combining
hemicyanine
dyes
ER-targeted
functional
groups
(p-toluenesulfonamide).
Owing
to
its
ability
target
ER
a
highly
specific
response
viscosity,
demonstrated
substantial
fluorescence
turn-on
only
after
binding
ER,
independent
other
physiological
environments.
In
addition,
ER-ZS,
being
small
molecule,
allows
nonalcoholic
fatty
liver
disease
(NAFLD)
via
imaging
based
on
high
stress.
Importantly,
is
type
I
photosensitizer,
producing
O
