Analytical Sciences,
Journal Year:
2024,
Volume and Issue:
40(4), P. 765 - 772
Published: Feb. 15, 2024
As
one
of
the
most
fundamental
thiol
compounds
in
human
body,
cysteine
(Cys)
is
involved
maintaining
redox
balance.
Abnormal
Cys
levels
can
lead
to
various
diseases.
In
this
work,
we
successfully
synthesized
a
fluorescent
probe
(CTBA)
that
specifically
detect
using
acrylate
as
reaction
site,
and
CTBA
has
met
selectivity
anti-interference
for
detection
under
optimized
conditions.
The
linear
range
between
0.05
100
μM
limit
0.0381
μM.
Finally,
used
content
three
bovine
serum
samples
test
results
are
satisfactory.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(9)
Published: Jan. 10, 2024
The
concept
of
molecular
design,
integrating
diagnostic
and
therapeutic
functions,
aligns
with
the
general
trend
modern
medical
advancement.
Herein,
we
rationally
designed
smart
molecule
ER-ZS
for
endoplasmic
reticulum
(ER)-targeted
diagnosis
treatment
in
cell
animal
models
by
combining
hemicyanine
dyes
ER-targeted
functional
groups
(p-toluenesulfonamide).
Owing
to
its
ability
target
ER
a
highly
specific
response
viscosity,
demonstrated
substantial
fluorescence
turn-on
only
after
binding
ER,
independent
other
physiological
environments.
In
addition,
ER-ZS,
being
small
molecule,
allows
nonalcoholic
fatty
liver
disease
(NAFLD)
via
imaging
based
on
high
stress.
Importantly,
is
type
I
photosensitizer,
producing
O
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
96(1), P. 272 - 280
Published: Dec. 22, 2023
Fluorescence
analysis
is
an
increasingly
important
contributor
to
the
early
diagnosis
of
kidney
diseases.
To
achieve
precise
visualization
kidneys
and
related
diseases,
asymmetric
pyrrolopyrrolidone
(DPP)
dye
platform
with
C-aromatic
substituents
N-lipophilic/hydrophilic
modification
was
constructed.
Based
on
these,
we
developed
renal-clearable,
water-soluble,
injury
biomarker
leucine
aminopeptidase
(LAP)
activated
ratiometric
fluorescent
probe
DPP-S-L.
In
mouse
model
cisplatin-induced
acute
during
development
type
2
diabetes
diabetic
disease,
visualized
for
first
time
upregulation
LAP
in
urine
by
dual-channel
fluorescence
signal
diagnosed
earlier
more
sensitively
than
blood/urine
enzyme
detection
tissue
analysis.
This
study
showcases
excellent
DPP
renal-clearable
design
strategy
that
extended
determination
other
biomarkers
disease
diagnosis.
