Lipid droplets targeting fluorescent probes with AIE properties for the diagnosis of fatty liver tissue DOI

Jie Wang,

Sichen Zhang, Jiale Li

et al.

Journal of Industrial and Engineering Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Visualizing dynamic interactions between mitochondria and lysosomes in living cells using novel pH-sensitive fluorescent probes in dual-channel DOI

Meng-Nan Li,

Jing-Yu Zhao,

Wenli Wang

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 412, P. 135743 - 135743

Published: April 4, 2024

Language: Английский

Citations

11
Monitoring the Mitochondrial Viscosity Changes During Cuproptosis with Iridium(III) Complex Probe via In Situ Phosphorescence Lifetime Imaging DOI
Gang Yang,

Ying Qing Zhao,

Lan Zhang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(15), P. 5931 - 5939

Published: April 4, 2024

Cuproptosis is a novel copper-dependent form of programmed cell death, displaying important regulatory functions in many human diseases, including cancer. However, the relationship between changes mitochondrial viscosity, key factor associated with cellular malfunction, and cuproptosis still unclear. Herein, we prepared phosphorescent iridium (Ir) complex probe for precisely monitoring viscosity during cuprotosis via phosphorescence lifetime imaging. The Ir possessed microsecond lifetimes (up to 1 μs), which could be easily distinguished from autofluorescence improve imaging contrast sensitivity. Benefiting long lifetime, excellent selectivity, targeting abilities, monitor increase (from 46.8 68.9 cP) quantitative manner. Moreover, through situ fluorescence imaging, successfully monitored zebrafish treated lipopolysaccharides or elescolomol-Cu2+, were well-known inducers. We anticipate that this new will useful tool in-depth understanding biological effects cuproptosis.

Language: Английский

Citations

4
A multipurpose mitochondrial NIR probe for imaging ferroptosis and mitophagy DOI

Deeksha Rajput,

Nachiket Pradhan,

Shabnam Mansuri

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(19), P. 4698 - 4707

Published: Jan. 1, 2024

A dicationic styrylpyridinium fluorophore for selective staining of mitochondria and investigation the associated physiological processes is described

Language: Английский

Citations

4
A “turn-on” intracellular pH probe for the quantitative monitoring of lysosomal alkalization in living cells DOI

H. Ke,

Jiaqi Yang,

Wanping Zhang

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 277, P. 117285 - 117285

Published: Feb. 19, 2025

Language: Английский

Citations

0
Hydroxyl and phenyl co-modified carbon nitride-based ratiometric fluorescent nanoprobe for monitoring mitochondrial pH in live cells and differentiating cell death DOI
Jingru Chen, Xiaomin Zhang, Heng Lu

et al.

Talanta, Journal Year: 2025, Volume and Issue: 291, P. 127843 - 127843

Published: Feb. 26, 2025

Language: Английский

Citations

0
A novel FRET-based fluorescent probe capable of simultaneously imaging lipid droplets and the endoplasmic reticulum with two distinct fluorescence signals in HeLa cells DOI
Tianzhen Liu,

Xiao-Hui Chi,

Bing-Yu Wei

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126262 - 126262

Published: April 1, 2025

Language: Английский

Citations

0
Monophenyl luminescent material with dual-state emission and pH sensitivity for cell imaging DOI Creative Commons
Yuxin Jin,

Bingli Jiang,

Huajian Song

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(16), P. 10942 - 10952

Published: Jan. 1, 2024

Dual-state emission (DSE) luminescent materials are a newly discovered category of that exhibit efficient light in multiple states, including dilute solutions, highly concentrated aggregated states and solid states. These effectively address the aggregation-caused quenching (ACQ) observed traditional organic with large conjugated planes, as well limitations aggregation-induced (AIE) materials, which typically do not emit solutions. The design development DSE for organelle imaging applications has attracted considerable interest. In this context, study presents synthesis novel compound, DMSS-AM, characterised by intramolecular hydrogen bonding D-π-A structure. As monophenyl material, DMSS-AM exhibits properties fluorescence quantum yields 22.1% solution 14.0% state. particular, it unique pH-responsive properties, facilitating targeted detection lysosomal pH changes. Confocal laser scanning microscopy cells demonstrated emitters at both low high concentrations affect image quality bio-imaging applications. This advance is expected to significantly broaden applicability future

Language: Английский

Citations

3
Dual-functional fluorescent probe for imaging ROS and hypoxia dynamic in cancer cells DOI
Yingchun Wu,

Chunying Wei

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 419, P. 136417 - 136417

Published: Aug. 5, 2024

Language: Английский

Citations

2
Nonlinear amplification of nano bowl surface concavity on the critical response threshold to biosignals DOI Creative Commons
Xuefeng Li, Liang Xin,

Cuiqin Yang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 8, 2024

Polymer nanoparticles that can sharply sense and detect biological signals in cells are promising candidates for biomedical theranostic nanomaterials. However, the response ability of current polymer assemblies poorly matches requirement trace concentration level (10

Language: Английский

Citations

2
“Three-key-and-lock” near-infrared fluorescent probe for dual-channel tracking ONOO− in mitochondria and viscosity in lysosomes in ferroptosis and drug-induced liver injury DOI
Yunfan Liu, Xuyan Wang, Nanyan Fu

et al.

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 225, P. 112102 - 112102

Published: March 16, 2024

Language: Английский

Citations

2