Paper‐in‐Tip Bipolar Electrospray Mass Spectrometry for Real‐Time Chemical Reaction Monitoring DOI
Yunwei Li,

Lixuan Zhu,

Xiaomeng Wu

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(30)

Published: May 8, 2024

Abstract Capturing short‐lived intermediates at the molecular level is key to understanding mechanism and dynamics of chemical reactions. Here, we have developed a paper‐in‐tip bipolar electrolytic electrospray mass spectrometry platform, in which piece triangular conductive paper incorporated into plastic pipette tip serves not only as an emitter but also electrode (BPE), thus triggering both electrolysis simultaneously upon application high voltage. The induces pair redox reactions on sides BPE, enabling electro‐oxidation electro‐reduction processes regardless positive or negative ion mode, facilitating access complementary structural information for elucidation. Our method enables real‐time monitoring transient (such N,N‐dimethylaniline radical cation, dopamine o‐quinone (DAQ) sulfenic acid with half‐lives ranging from microseconds minutes) DAQ cyclization rate constant 0.15 s −1 ). This platform provides insights electrocatalytic such Fe (III)‐catalyzed oxidation quinone species physiological pH neuromelanin formation.

Language: Английский

Paper‐in‐Tip Bipolar Electrospray Mass Spectrometry for Real‐Time Chemical Reaction Monitoring DOI
Yunwei Li,

Lixuan Zhu,

Xiaomeng Wu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(30)

Published: May 8, 2024

Abstract Capturing short‐lived intermediates at the molecular level is key to understanding mechanism and dynamics of chemical reactions. Here, we have developed a paper‐in‐tip bipolar electrolytic electrospray mass spectrometry platform, in which piece triangular conductive paper incorporated into plastic pipette tip serves not only as an emitter but also electrode (BPE), thus triggering both electrolysis simultaneously upon application high voltage. The induces pair redox reactions on sides BPE, enabling electro‐oxidation electro‐reduction processes regardless positive or negative ion mode, facilitating access complementary structural information for elucidation. Our method enables real‐time monitoring transient (such N,N‐dimethylaniline radical cation, dopamine o‐quinone (DAQ) sulfenic acid with half‐lives ranging from microseconds minutes) DAQ cyclization rate constant 0.15 s −1 ). This platform provides insights electrocatalytic such Fe (III)‐catalyzed oxidation quinone species physiological pH neuromelanin formation.

Language: Английский

Citations

1
Ambient catalyst-free oxidation reactions of aromatic amines using water radical cations DOI Creative Commons
Xiaoping Zhang,

Pinghua Hu,

Minmin Duan

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(39), P. 16125 - 16132

Published: Jan. 1, 2024

Hydroxyl quaternization through the direct oxidation reaction of aromatic amines, facilitated by water radical cations within microdroplets, is explored.

Language: Английский

Citations

0
In-situ reaction monitoring and kinetics study of photochemical reactions by optical focusing inductive electrospray mass spectrometry DOI

Yongyi Li,

Jin Han,

Xiangyu Wang

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110708 - 110708

Published: Dec. 1, 2024

Language: Английский

Citations

0
Paper‐in‐Tip Bipolar Electrospray Mass Spectrometry for Real‐Time Chemical Reaction Monitoring DOI
Yunwei Li,

Lixuan Zhu,

Xiaomeng Wu

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(30)

Published: May 8, 2024

Abstract Capturing short‐lived intermediates at the molecular level is key to understanding mechanism and dynamics of chemical reactions. Here, we have developed a paper‐in‐tip bipolar electrolytic electrospray mass spectrometry platform, in which piece triangular conductive paper incorporated into plastic pipette tip serves not only as an emitter but also electrode (BPE), thus triggering both electrolysis simultaneously upon application high voltage. The induces pair redox reactions on sides BPE, enabling electro‐oxidation electro‐reduction processes regardless positive or negative ion mode, facilitating access complementary structural information for elucidation. Our method enables real‐time monitoring transient (such N,N‐dimethylaniline radical cation, dopamine o‐quinone (DAQ) sulfenic acid with half‐lives ranging from microseconds minutes) DAQ cyclization rate constant 0.15 s −1 ). This platform provides insights electrocatalytic such Fe (III)‐catalyzed oxidation quinone species physiological pH neuromelanin formation.

Language: Английский

Citations

0