Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: unknown, P. 137020 - 137020
Published: Nov. 1, 2024
Language: Английский
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Detecting and quantifying mycotoxins using LFIA are challenging due to the need for high sensitivity accuracy. To address this, a dual-mode colorimetric-SERS was developed detecting deoxynivalenol (DON). Rhodium nanocores provided strong plasmonic properties as SERS substrate, while silver nanoparticles created electromagnetic "hotspots" enhance signal sensitivity. Finite element modeling optimized field intensity, Prussian blue generated distinct at 2156 cm-1, effectively reducing background interference. This achieved detection limit of 4.21 pg/mL, 37 times lower than that colloidal gold-based (0.156 ng/mL). Machine learning algorithms, including ANN KNN, enabled precise classification quantification contamination, achieving 98.8% accuracy an MSE 0.57. These results underscore platform's potential analyzing harmful substances in complex matrices demonstrate important role machine learning-enhanced nanosensors advancing technologies.
Language: Английский
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Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110967 - 110967
Published: Feb. 1, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Since the 1980s, surface enhanced Raman scattering (SERS) has been used for rapid and sensitive detection of biomolecules. Whether a label-free or labeled assay is adopted, SERS demonstrated low limits in variety biological matrices. However, analysis confined to laboratory due several reasons such as reproducibility scalability, both which have discussed at length literature. Another possible issue with lack widespread adoption that its application point use (POU) testing only now being fully explored advent portable spectrometers. Researchers are investigating how can be output on POU platforms lateral flow assays, wearable sensors, volatile organic compound (VOC) human healthcare monitoring, favorable results rival gold standard approaches. obstacle faces interpretation wealth information obtained from platform. To combat this, machine learning shown provide quick accurate generated data, leading discrimination many clinically relevant This review will discuss advancements combined strength bring produce powerful platform monitoring.
Language: Английский
Citations
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Chemosensors, Journal Year: 2025, Volume and Issue: 13(3), P. 112 - 112
Published: March 19, 2025
The increasing prevalence of pathogen outbreaks underscores the urgent need for rapid, accurate, and cost-effective diagnostic tools. Colorimetric detection has gained significant attention among available techniques due to its simplicity, portability, potential point-of-care applications. nanomaterial-based colorimetric field continues evolve, with innovations focusing on improving sensitivity, specificity, robustness, cost-effectiveness, friendly analysis. Additionally, efforts address limitations, such as stability environmental impact, pave way more sustainable reliable solutions. This review highlights recent advances in nanomaterials last five years.
Language: Английский
Citations
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Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Pathogenic Escherichia coli (E. coli) is a widespread and clinically significant foodborne pathogen. Due to its high mutation rates phenotypic diversity, rapid identification of subtypes remains challenging prone false positives when detecting single strains. In this study, we developed plasmonic sensor array with high-dimensional signal readouts (ζ-potential, dynamic light-scattering (DLS), surface-enhanced Raman scattering (SERS), ultraviolet-visible (UV-vis) absorption spectra) for the selective discrimination pathogenic E. coli, integrated bacterial culture methods. The units demonstrated strong encoding capabilities, facilitating differentiation subtle variations among various strains showing excellent anti-interference performance. realized different strains, mixture identification, even quantitative detection. Remarkably, working concentration was notably low, at 104 CFU/mL. Finally, by incorporating isolation culture, designed obtained 100% accuracy in real food samples. These findings highlight array's potential applications safety monitoring clinical diagnostics, offering sensitive, rapid, reliable tool pathogen detection complex
Language: Английский
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Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1355, P. 344017 - 344017
Published: April 5, 2025
Language: Английский
Citations
0
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
This study presents the development of a dual-function microdroplet sensor utilizing surface-enhanced Raman scattering (SERS) technology to identify and quantify Influenza A COVID-19 viruses. The proposed microfluidic device incorporates compartments for two-phase segmented droplet generation, merging, splitting, detection. Both viral strains were identified by isolating magnetic antibody-antigen complexes from liquid medium using magnetized bar embedded in channel. Concurrent spectroscopic readings obtained as suspended droplets containing residual SERS-active nanoparticles traversed interrogation zone focused laser beam. Precise quantitative analysis was accomplished correcting characteristic peak intensities both viruses with internal standards, while ensemble averaging signals multiple ensured high reproducibility. SERS represents novel vitro diagnostic approach capable rapidly distinguishing between sensitivity When coupled portable spectrophotometer, shows significant potential tool swift situ detection pathogens.
Language: Английский
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Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162799 - 162799
Published: April 1, 2025
Language: Английский
Citations
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Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 2, 2025
Over the years, evolution of point-of-care testing (POCT) has been driven by technological advancements in materials, design, and artificial intelligence, as well breakthrough developments wearable technologies. These innovations are shifting diagnostics from centralized medical facilities to individual homes, meeting growing demand for personalized healthcare. This Review explores recent binding-based assay technologies over past two focusing on platforms such traditional flow assays (lateral vertical flow), fully integrated microfluidic devices, biosensor-integrated systems POCT applications. It emphasizes role optical electrochemical detection methods, which essential ensuring sensitivity, specificity, reliability required a POCT. offer advantages including ease use, high diagnostic accuracy, rapid clinical assessment, cost-effectiveness manufacturing consumables. Additionally, highlights current challenges future perspectives delivering healthcare through portable that operate sample-in, result-out basis.
Language: Английский
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Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137283 - 137283
Published: Jan. 18, 2025
Language: Английский
Citations
0