19F-Labeled NMR Probes for the Detection and Discrimination of Nitrogen-Containing Analytes DOI
Yanchuan Zhao,

Guangxing Gu,

Chenyang Wang

et al.

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract The development of 19F-labeled NMR probes has become a pivotal tool in analytical chemistry. Recent advancements probe design enable precise identification nitrogen-containing analytes, significantly enhancing the analysis these biologically important analytes complex mixtures. This short review highlights recent progress with based on covalent derivatization and dynamic exchange strategies, which yield distinct 19F signals for each analyte. These strategies facilitate separation-free multicomponent chiral discrimination. Discussions will cover principles, scope, limitations, to enhance sensitivity resolving ability. By addressing current challenges, hold potential revolutionize detection relevant molecules, catalyzing new discoveries chemical biochemical research. 1 Introduction 2 19F-Labeled Probes Based Covalent Derivatization 2.1 Non-Chiral 2.2 Chiral 3 Dynamic Ligand Exchange 3.1 3.2 4 Conclusion Outlook

Language: Английский

Exploring the Chiral Match–Mismatch Effect in the Chiral Discrimination of Nitriles DOI

Guangxing Gu,

Yining Sun,

Chenyang Wang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

This study tackles the challenge of enantiodifferentiation nitrile compounds, which is typically difficult to resolve using nuclear magnetic resonance (NMR) due significant distance between chiral center and nitrogen atom involved in molecular interactions. We have developed novel 19F-labeled probes, each featuring two centers, exploit "match-mismatch" effect, thereby enhancing enantiodiscrimination. strategy effectively differentiates analytes with quaternary carbon centers as well those similar substituents at center. Our approach not only provides a method for precise probe performance optimization but also offers rapid efficient technique screening reaction conditions asymmetric synthesis.

Language: Английский

Citations

0
19F NMR-Based Lithium Sensors Using 19F-Labeled Aza-Crown Ethers: Regioisomeric and Substituent Effects DOI

Donghyeon Lee,

Yanchuan Zhao, Byungjin Koo

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112762 - 112762

Published: March 1, 2025

Language: Английский

Citations

0
Chiral Optical Sensing of Amino Acids with 2-Trifluoromethyl Benzaldehyde for Ophiopogon japonicus Authentication DOI

Xijian Wu,

Zhongbo Su, Biling Huang

et al.

Journal of Natural Products, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

The detection and analysis of chiral molecules have long been challenging in analytical chemistry. This study introduces a novel approach that utilizes 2-trifluoromethyl benzaldehyde as small-molecule probe capable forming stable Schiff base with amino acids aqueous solution under alkaline conditions. acid bases present strong Cotton effect UV absorption at wavelengths exceeding 260 nm, enabling analysis, including assignment absolute configuration, enantiomeric composition, total concentration. An application this method was the authentication herbal medicine Ophiopogon japonicus. Using principal component orthogonal partial least squares discriminant we successfully differentiated O. japonicus samples collected two distinct locations 20 samples. rapid convenient offers new to quality control medicine.

Language: Английский

Citations

0
19F NMR-Based Chiral Analysis of Organoboron Compounds via Chiral Recognition of Fluorine-Labeled Boronates with Cobalt Complexes DOI Creative Commons

Hahyoun Park,

Cham Bi Seo,

Jaesook Yun

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(10), P. 3771 - 3776

Published: Sept. 16, 2024

This study aims to develop a method for the chiral analysis of organoboron compounds using nuclear magnetic resonance (NMR) spectroscopy. It addresses longstanding challenge associated with these compounds, which often require derivatization and pretreatment prior chromatographic analysis. Our utilizes tridentate ligands facilitate effective ligand exchange incorporates fluorine labels, allowing precise discrimination

Language: Английский

Citations

0
19F-Labeled NMR Probes for the Detection and Discrimination of Nitrogen-Containing Analytes DOI
Yanchuan Zhao,

Guangxing Gu,

Chenyang Wang

et al.

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract The development of 19F-labeled NMR probes has become a pivotal tool in analytical chemistry. Recent advancements probe design enable precise identification nitrogen-containing analytes, significantly enhancing the analysis these biologically important analytes complex mixtures. This short review highlights recent progress with based on covalent derivatization and dynamic exchange strategies, which yield distinct 19F signals for each analyte. These strategies facilitate separation-free multicomponent chiral discrimination. Discussions will cover principles, scope, limitations, to enhance sensitivity resolving ability. By addressing current challenges, hold potential revolutionize detection relevant molecules, catalyzing new discoveries chemical biochemical research. 1 Introduction 2 19F-Labeled Probes Based Covalent Derivatization 2.1 Non-Chiral 2.2 Chiral 3 Dynamic Ligand Exchange 3.1 3.2 4 Conclusion Outlook

Language: Английский

Citations

0