Screening drug-induced liver injury through two independent parameters of lipid droplets and peroxynitrite with a π-extended coumarin-based NIR fluorescent probe

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 410, P. 135659 - 135659

Published: March 19, 2024

Language: Английский

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Advances in Organic Fluorescent Probes for Intracellular Zn2+ Detection and Bioimaging

Molecules, Journal Year: 2024, Volume and Issue: 29(11), P. 2542 - 2542

Published: May 28, 2024

Zinc ions (Zn2+) play a key role in maintaining and regulating protein structures functions. To better understand the intracellular Zn2+ homeostasis signaling role, various fluorescent sensors have been developed that allow monitoring of concentrations bioimaging live cells real time. This review highlights recent development organic probes for detection imaging Zn2+, including design construction probes, response mechanisms, their applications to on-site. Finally, current challenges prospects are discussed.

Language: Английский

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An ɑ-ketoamide-based fluorescent probe via aggregation induced emission for ONOO- detection in vivo

Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 128064 - 128064

Published: April 1, 2025

Language: Английский

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A FRET/TICT based multifunctional fluorescent probe for the monitoring of SO2 derivatives and viscosity in living cells and real samples

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 325, P. 125074 - 125074

Published: Aug. 31, 2024

Language: Английский

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Multifunctional Sensors for Successive Detection of Endogenous ONOO^– and Mitochondrial Viscosity: Discriminating Normal to Cancer Models

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(41), P. 16289 - 16297

Published: Sept. 30, 2024

Diagnosing cancer in its early stages can play an important role prolonging the lifespan of patients, which demands use powerful tools to detect biomarkers accurately. However, since most fluorescent probes described for diagnosis are limited recognizing a single molecule, achieving high accuracy criteria remains difficult. Here, sensor

Language: Английский

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Splitting and Aggregation of Carbon Dots: Wavelength-Shifted and Ratiometric Fluorescence Sensing of Peroxynitrite

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Peroxynitrite (ONOO

Language: Английский

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A novel ultra-sensitive fluorescent probe for monitoring and imaging drug-induced/inhibited ferroptosis-mediated liver injury model via peroxynitrite fluctuations

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112833 - 112833

Published: Jan. 1, 2025

Language: Английский

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An imidazo-pyridin derivative as fluorescent probe for the peroxynitrite detection in pulmonary permissive hypercapnia

Analytical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

The physiological and pathological processes in lungs indicated that ONOO- acted as an informative indicator for pulmonary functioning status with the corresponding dynamics, especially permissive hypercapnia. Herein, peroxynitrite (ONOO-) detection imaging living lung cells, imidazo-pyridin derived fluorescent probe IDPD-ONOO was developed. recognized to exhibit a fluorescence response at 490 nm excitation wavelength 355 nm. advantages of developed included practical linear range (0-100 μM), high sensitivity (Limit Detection 0.005 rapid (within 15 min), pH tolerance (7.0-9.0), selectivity, low cyto-toxicity. Furthermore, achieved intracellular both exogenous endogenous level, which meaningful research on mechanism optimized optical implements.

Language: Английский

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Ratiometric fluorescent probe for triphosgene detection and its application in electrospun fluorescent fibers

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126149 - 126149

Published: April 1, 2025

Language: Английский

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A Novel “Double-Responsive” and “Dual-Targeted” Multifunctional Fluorescent Probe Monitors the Level Changes of ONOO^– in Mitochondria during Cell Pyroptosis

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Pyroptosis, often referred to as inflammatory necrosis, is a type of programmed cell death, characterized by the swelling cells until membranes rupture, resulting in release intracellular substances and strong response. Lipid droplets mitochondria play important roles cellular activities. A correlation exists between pyroptosis mitochondrial dysfunction, which can be reflected through physiological functions involves changes microenvironment morphology. In this work, "double-responsive" "dual-targeted" fluorescent probe named WD-2 was constructed. It has excellent response performance viscosity ONOO-, simultaneously monitor relevant levels lipid mitochondria. Its remarkable targeting ability toward been verified colocalization experiments. imaging experiments, interaction during nutritional stress preliminarily studied. With help doxorubicin hydrochloride, level ONOO- were explored, providing new perspective for understanding mechanism process.

Language: Английский

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