A HClO-activated BODIPY based ratiometric fluorescent probe with dual near-infrared channels for differentiating cancerous cells from normal cells and surgical guidance of tumor resection

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 275, P. 117247 - 117247

Published: Feb. 7, 2025

Language: Английский

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A High Signal-to-Noise Ratio NIR Fluorescent Probe for Viscosity Detection in NAFLD Diagnosis

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137581 - 137581

Published: March 1, 2025

Language: Английский

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Recent Progress in Molecular Probes for Imaging of Acute Kidney Injury

Chemical & Biomedical Imaging, Journal Year: 2024, Volume and Issue: 2(8), P. 526 - 541

Published: May 1, 2024

Acute kidney injury (AKI), a prevalent and complex clinical condition associated with elevated risks of morbidity mortality, necessitates the meticulous detection monitoring damage globally. Biomedicine has shown keen interest in molecular probes detectors for AKI due to their sensitivity, rapidity, cost-effectiveness. Bioimaging technologies play significant role identifying quantifying indicators, enhancing diagnostic approaches, potentially refining therapies immediate control. Molecular serve as valuable tools drug screening, uncovering renoprotective components, signaling pathways, nephrotoxic effects drugs. This review comprehensively summarizes latest advancements probes, emphasizing exceptional efficacy various characteristics, including renal cleanability, multichannel capability, near-infrared-II responsiveness, reactivity toward reactive oxygen species. These offer enhanced benefits assessing evaluating therapeutic medications while simultaneously reducing toxic effects. Additionally, delves into future potentials challenges this field, aiming inspire development enhancement bioimaging early diagnosis treatment diseases.

Language: Английский

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Multicomponent synthesis and photophysical properties of meso-thienyl BODIPY-pyrrolo[3,4-b]pyridin-5-ones. An experimental and theoretical study

Journal of Luminescence, Journal Year: 2024, Volume and Issue: 273, P. 120698 - 120698

Published: May 27, 2024

Language: Английский

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Screening Anti-Parkinson’s Disease Drugs in Living Mouse Brains via a Peroxynitrite-Activated Fluorescent Probe

Chemical & Biomedical Imaging, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Screening anti-Parkinson's disease (PD) drugs at in vivo brain level is imperative for managing PD yet currently remains unaccomplished. Peroxynitrite (ONOO–) has been implicated progression. Thus, developing ONOO–-based imaging tools anti-PD drug screening holds promise early prognosis and treatment of PD. Consequently, a near-infrared (NIR) fluorescence probe, BOB-Cl-PN, with high specificity, good sensitivity (LOD = 24 nM), rapid response (<60 s), was devised to investigate ONOO– relationships. Utilizing NIR imaging, BOB-Cl-PN effectively monitored fluctuations 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced cell models, establishing cellular throughput (cHTS) system drugs. In live animal BOB-Cl-PN's ability penetrate the blood–brain barrier enabled flux mouse brains. Moreover, served as an contrast potential traditional Chinese medicines therapy, identifying fisetin having best therapeutic index among 10 medicines. This study constructs sensitive, efficient monitoring dynamics brains provides valuable platform

Language: Английский

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Integration of Melanin-Resveratrol Nanosystem for the Diagnostic-therapeutic of Renal Fibrosis

Chemical Research in Chinese Universities, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Language: Английский

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