Lipid droplets targeting fluorescent probes with AIE properties for the diagnosis of fatty liver tissue DOI

Jie Wang,

Sichen Zhang, Jiale Li

et al.

Journal of Industrial and Engineering Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Versatile organic fluorescent probes for visualizing the dynamics of lipid droplets DOI

Mingyue Cao,

Yunting Liu,

Caihong Xiang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216181 - 216181

Published: Sept. 5, 2024

Language: Английский

Citations

20
New AIE Emitters from the Unexpected Boron Tribromide/Boron Trichloride‐mediated Cyclization Reaction and Application for Fluorescence Imaging of Lipid Droplets DOI Creative Commons
Yichen Hu, Xin Gao, Junlong Ma

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

ABSTRACT The aberrant behavior of lipid droplets (LDs) is often indicative cellular dysfunction, which may contribute to the development a range diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and atherosclerosis (AS). Consequently, there an urgent need develop fluorescence probes targeting LDs monitor progression disease. In this study, unanticipated one‐pot boron tribromide (BBr₃)/boron trichloride (BCl₃)‐promoted cyclization reaction was discovered, yielding bromo‐/chloro‐substituted triphenylamine (TPA) derivative ( TPA‐Br / TPA‐Cl ). successfully transformed into new TPA‐containing donor‐acceptor (D–A) molecules show typical aggregation induced emission (AIE) property. Among these AIE emitters, TPA‐N shows most promising specificity, lowest toxicity best photo‐stability. Ex vivo studies further demonstrate that can be used image fatty AS plaque quickly effectively.

Language: Английский

Citations

1
Detecting Changes in Singlet Oxygen and Viscosity during Apoptosis-Ferroptosis Mediated Photodynamic Therapy and Establishing Visual Imaging of Fatty Liver DOI

Yingshu Dai,

Limei Xiao,

Jie Liao

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Cancer is a serious global health threat, and photodynamic therapy (PDT) an effective treatment method for cancer. This works by generating large amount of singlet oxygen (1O2) under the influence light, which induces apoptosis in tumor cells, leading to their destruction. However, resistance cells limits development PDT, thus combination ferroptosis provides new perspective PDT. During PDT ferroptosis, levels 1O2 microenvironment (viscosity) within often change. To address this, this study developed novel fluorescent probe, NI–QM-OH, based on TICT–ICT effect, capable monitoring changes viscosity during The probe exhibits excellent selectivity, high sensitivity, low LOD (0.38 μM), has been successfully applied bioimaging HepG2, HeLa, MCF-7 as well zebrafish. Most importantly, NI–QM–OH also enables visualization diagnosis fatty liver disease (both alcoholic nonalcoholic).

Language: Английский

Citations

0
A potent fluorescent probe for HOCl with dual NIR emissions: achieving the early diagnosis of polystyrene microplastics-induced liver injury involved in ferroptosis DOI
Jianwei Cui,

James T. C. Teng,

Peini Xiang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138087 - 138087

Published: March 1, 2025

Language: Английский

Citations

0
Recent advances in fluorescent probes for bioimaging lipid droplets associated diseases DOI

Wenli Jiang,

Kexin Du, Jing Zhang

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112792 - 112792

Published: March 1, 2025

Language: Английский

Citations

0
Synthesis and performance research of an AIE molecule DOI

Yuehua Liang,

Jiuzhi Wei,

Juan Zhang

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 116420 - 116420

Published: April 1, 2025

Language: Английский

Citations

0
A Novel “Double-Responsive” and “Dual-Targeted” Multifunctional Fluorescent Probe Monitors the Level Changes of ONOO– in Mitochondria during Cell Pyroptosis DOI
Di Wei,

Yingshu Dai,

Xixian Yan

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Pyroptosis, often referred to as inflammatory necrosis, is a type of programmed cell death, characterized by the swelling cells until membranes rupture, resulting in release intracellular substances and strong response. Lipid droplets mitochondria play important roles cellular activities. A correlation exists between pyroptosis mitochondrial dysfunction, which can be reflected through physiological functions involves changes microenvironment morphology. In this work, "double-responsive" "dual-targeted" fluorescent probe named WD-2 was constructed. It has excellent response performance viscosity ONOO-, simultaneously monitor relevant levels lipid mitochondria. Its remarkable targeting ability toward been verified colocalization experiments. imaging experiments, interaction during nutritional stress preliminarily studied. With help doxorubicin hydrochloride, level ONOO- were explored, providing new perspective for understanding mechanism process.

Language: Английский

Citations

0
Innovative Application of Conventional Hydrazone Analogues as Photocages with Ultrahigh Photolysis Efficiency for Dynamic Bioimaging and Prodrug Construction DOI
Hongmei Wu,

Yongxiao Sun,

Yanbing Ke

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137907 - 137907

Published: May 1, 2025

Language: Английский

Citations

0
Trends in small-molecule probes for lipid droplets DOI
Yi Tu, Wenjie Zhang,

Jiaqian Yan

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118287 - 118287

Published: May 1, 2025

Language: Английский

Citations

0
Ratiometric Red-Emitting Probe with Large Stokes Shift and AIE/ESIPT Characteristics for Acetylcholinesterase Imaging DOI
Chunbai Xiang, Qihang Ding, Ting Jiang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Overexpression of acetylcholinesterase (AChE) plays a pivotal role in disrupting acetylcholine (ACh) signaling, contributing to the neurodegenerative processes observed Alzheimer's disease (AD). Detecting AChE activity is crucial for understanding progression and developing effective therapeutic strategies. In this study, we present novel fluorescent probe, DPHP-AChE, which leverages large Stokes shifts (188 nm) ratiometric fluorescence outputs based on aggregation-induced emission (AIE) excited-state intramolecular proton transfer (ESIPT) mechanisms. This probe enables efficient reliable imaging living systems, offering enhanced sensitivity increased resistance aggregation-caused quenching (ACQ). The shift improves signal-to-noise ratio facilitates more accurate real-time quantification expression. We believe that innovative approach opens up new possibilities specific detection AChE, can be further extended diagnosis monitoring AChE-related pathologies.

Language: Английский

Citations

0