Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158797 - 158797
Published: Dec. 1, 2024
Language: Английский
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: Jan. 11, 2025
Language: Английский
Citations
1
Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The microfluidic-based technique that combines efficient isolation of EVs and multiple detection EV cargos like proteins, nucleic acids, glycans at bulk, single/single cell level to further demystify heterogeneity.
Language: Английский
Citations
0
Analytical and Bioanalytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 22, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: May 22, 2025
Extracellular vesicles (EVs) are lipid membrane-bound involved in cell-cell communication, particularly the context of cancer. Immunotherapy, a rapidly evolving field oncology, is type cancer treatment relying on body’s own immune system to fight mutated cells. Recently, significance immunotherapeutic resistance has been increasingly acknowledged owing heightened prevalence and its commonly advanced stage upon diagnosis. However, complexity heterogeneity tumor cells pose challenges immunotherapy, role EVs remains unclear. Recent studies focused as heterogeneous groups nanoparticles intercellular within microenvironment (TME). EVs, which include exosomes, shed microvesicles, while apoptotic bodies carry diverse range molecular cargo, including proteins, nucleic acids, lipids, other bioactive molecules. The versatility make them fascinating area study, with promising implications for future immunology medicine. This brief review highlights involvement (e.g., PD-L1 transfer, miRNA-mediated pathways) focus their biogenesis, secretion, functional roles cancer, underscoring potential diagnostic therapeutic tools.
Language: Английский
Citations
0
Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 128049 - 128049
Published: March 1, 2025
Language: Английский
Citations
0
Biosensors and Bioelectronics X, Journal Year: 2024, Volume and Issue: 19, P. 100514 - 100514
Published: July 5, 2024
Nanozyme cascade have garnered substantial interest in recent years due to their distinctive properties. However, the conventional stepwise reaction undergoes tedious two-step operation process owing incompatibility of conditions. Moreover, most reported nanozymes exhibit favorable catalytic performance only acidic medium, which greatly restricts usage especially biochemical analysis. To address above challenges, we developed gold nanoparticles/calcium hexacyanoferrate (Ⅲ)/nitrogen-doped graphitic alkyne (AuNPs/CaHF NPs/N-GDY) nanozyme with superior activity at neutral pH comparable that acidic. Specifically, AuNPs/CaHF NPs/N-GDY simultaneously possessed glucose oxidase-like (GOx) and peroxidase-like (HRP) activities, could induce one-step presence glucose, resulting 5-fold enhancement efficiency compared reaction. Besides, tripedal DNA walker was equipped sufficient walking legs walk on directional highly controllable stepped track, reducing possibility derailment boosting efficiency. As a proof concept, novel electrochemical biosensor constructed for miRNA-21 sensitive detection physiological pH, successfully applied human serum samples as well practical intracellular analysis, offering great potential biomedical research clinical diagnosis.
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158797 - 158797
Published: Dec. 1, 2024
Language: Английский
Citations
0