New insights into lipid and fatty acid metabolism from Raman spectroscopy. DOI Creative Commons

Justin C. Greig,

William J. Tipping, Duncan Graham

et al.

The Analyst, Journal Year: 2024, Volume and Issue: 149(19), P. 4789 - 4810

Published: Jan. 1, 2024

One of the challenges facing biology is to understand metabolic events at a single cellular level. While approaches examine dynamics protein distribution or report on spatiotemporal location signalling molecules are well-established, tools for dissection metabolism in living cells less common. Advances Raman spectroscopy, such as stimulated scattering (SRS), beginning offer new insights into range experimental systems, including model organisms and clinical samples, across disciplines. Despite power imaging, it remains relatively under-used technique approach biological problems, part because specialised nature analysis. To raise profile this method, here we consider some key studies which illustrate how spectroscopy has revealed fatty acid lipid systems. The powerful non-invasive offers suite biomolecular scientists address within informs underpins function. We potential applications, discuss recent advances, direction travel research area.

Language: Английский

Illuminating life processes by vibrational probes DOI
Naixin Qian, Zhilun Zhao, Elsy El Khoury

et al.

Nature Methods, Journal Year: 2025, Volume and Issue: 22(5), P. 928 - 944

Published: May 1, 2025

Language: Английский

Citations

1
Advancements of UV-Vis Spectroscopy in Drug Discovery DOI

Rashmi Rashmi,

A. Sagar,

Vijay Kumar Juyal

et al.

Advances in chemical and materials engineering book series, Journal Year: 2025, Volume and Issue: unknown, P. 97 - 132

Published: Feb. 14, 2025

UV-Vis spectroscopy is a crucial and advanced analytical tool in the pharmaceutical industry, analyzing compounds by measuring light absorption 200-400 nm range. Recent advancements have improved its sensitivity, precision, speed, aiding rapid drug screening real-time monitoring. It assesses identity, strength, purity of compounds, as well raw materials, intermediates. also for evaluating stability, solubility, bioavailability, enhancing development regulatory compliance. Overall, plays pivotal role refining lead ensuring quality control, adhering to standards, solidifying importance industry.

Language: Английский

Citations

0
New insights into lipid and fatty acid metabolism from Raman spectroscopy. DOI Creative Commons

Justin C. Greig,

William J. Tipping, Duncan Graham

et al.

The Analyst, Journal Year: 2024, Volume and Issue: 149(19), P. 4789 - 4810

Published: Jan. 1, 2024

One of the challenges facing biology is to understand metabolic events at a single cellular level. While approaches examine dynamics protein distribution or report on spatiotemporal location signalling molecules are well-established, tools for dissection metabolism in living cells less common. Advances Raman spectroscopy, such as stimulated scattering (SRS), beginning offer new insights into range experimental systems, including model organisms and clinical samples, across disciplines. Despite power imaging, it remains relatively under-used technique approach biological problems, part because specialised nature analysis. To raise profile this method, here we consider some key studies which illustrate how spectroscopy has revealed fatty acid lipid systems. The powerful non-invasive offers suite biomolecular scientists address within informs underpins function. We potential applications, discuss recent advances, direction travel research area.

Language: Английский

Citations

3