Amplified electrochemiluminescence of Ru(dcbpy)32+ via coreactant active sites on nitrogen-doped graphene quantum dots
Lingyue Guo,
No information about this author
Libo Li,
No information about this author
Lijun Luo
No information about this author
et al.
Talanta,
Journal Year:
2025,
Volume and Issue:
286, P. 127554 - 127554
Published: Jan. 13, 2025
Language: Английский
Nanomaterials-Integrated CRISPR/Cas Systems: Expanding the Toolbox for Optical Detection
ACS Sensors,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Nanomaterials-integrated
CRISPR/Cas
systems
have
rapidly
emerged
as
powerful
next-generation
platforms
for
optical
biosensing.
These
integrated
harness
the
precision
of
CRISPR/Cas-mediated
nucleic
acid
detection
while
leveraging
unique
properties
nanomaterials
to
achieve
enhanced
sensitivity
and
expanded
analytical
capabilities,
thereby
broadening
their
diagnostic
potential.
By
incorporating
a
diverse
range
nanomaterials,
these
effectively
expand
toolbox
detection,
offering
adaptable
solutions
tailored
various
challenges.
This
review
provides
comprehensive
overview
successfully
into
CRISPR/Cas-based
sensing
systems.
It
examines
multiple
modalities,
including
fluorescence,
electrochemiluminescence,
colorimetry,
surface-enhanced
Raman
spectroscopy,
highlighting
how
facilitate
signal
amplification,
enable
multiplexing,
support
development
point-of-care
applications.
Additionally,
practical
applications
in
critical
fields
such
healthcare
diagnostics
environmental
monitoring
are
showcased.
While
offer
considerable
advantages,
several
real-world
challenges
complexity
assay
workflows,
impact
cost,
regulatory
hurdles
must
be
addressed
before
widespread
implementation
can
achieved.
identifying
obstacles
proposing
strategic
solutions,
we
aim
pave
way
continued
advancement
adoption
nanomaterial-integrated
biosensing
technologies.
Language: Английский
Development and application of DNA hydrogels in biosensing: Current status and future implications
Microchemical Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 113664 - 113664
Published: April 1, 2025
Language: Английский
Electrochemiluminescence Biosensor Based on an Efficient Antifouling Cell Membrane Hydrogel for the Direct Detection of Alkaline Phosphatase in Human Serum and Cell Lysate
Qiongwei Wu,
No information about this author
Zhengjun Dong,
No information about this author
Fan Geng
No information about this author
et al.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 19, 2025
Electrochemiluminescence
(ECL)
biosensors
are
an
ideal
choice
for
the
real-time
and
sensitive
detection
of
biomarkers.
However,
there
many
interfering
biomolecules
in
human
serum
or
cell
lysate
that
can
affect
ECL
signal
through
nonspecific
interface
adsorption.
To
solve
this
issue,
efficient
antifouling
biosensor
based
on
a
red
blood
membrane
(RBCM)
hydrogel
was
developed
direct
alkaline
phosphatase
(ALP)
lysate.
Among
them,
RBCM
prepared
by
embedding
purified
vesicles
into
[1,2-distearoyl-sn-glycerol-3-phosphoethanolamine]-[polyethylene]-[acrylamide]
(DSPE-PEG-AM),
which
endowed
with
high
stability
biocompatibility.
Meanwhile,
compared
to
RBCM,
constructed
improved
electron
transfer
rate
interface.
Furthermore,
luminescent
copper
nanosheets
(Cu
NSs)
quencher
MnO2
NSs
were
encapsulated
hydrogel,
greatly
reduced
distance
between
Cu
NSs,
thereby
effectively
improving
quenching
efficiency.
In
presence
ALP,
l-ascorbic
acid
2-phosphate
trisodium
salt
hydrolyzed
ascorbic
acid,
thus
disrupting
structure
restore
signal.
Based
above
sensing
strategies,
achieved
ultrasensitive
ALP
wide
linear
range
(10-5
104
U·L-1)
limit
as
low
3.4
×
10-6
U·L-1
(3δ/k),
demonstrating
potential
application
value
clinical
diagnosis.
Language: Английский
Progress in electrochemiluminescence of metal nanoclusters
Chemical Physics Reviews,
Journal Year:
2024,
Volume and Issue:
5(4)
Published: Dec. 1, 2024
Metal
nanoclusters
(NCs)
composed
of
metal
atoms
and
ligands
show
promise
as
electrochemiluminescent
(ECL)
materials
due
to
their
optical
electrochemical
properties.
This
review
provides
a
comprehensive
overview
the
ECL
mechanisms,
advantages,
roles
NCs
luminophores,
catalysts,
quenchers,
substrates,
carriers.
Insights
into
factors
that
influence
in
will
lay
foundation
for
future
research.
In
addition,
applications
metallic
NC-based
detection
platforms
are
summarized,
potential
research
directions
presented.
Language: Английский