Near-infrared lipid droplet polarity fluorescent probe based on phenothiazine derivative for diagnosis of non-alcoholic fatty liver and tumors DOI

Aobo Sun,

Jiale Li, Jie Wang

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126430 - 126430

Published: May 1, 2025

Language: Английский

Uncovering the Fluctuation of Peroxynitrite during Early Embryonic Development Using an Integrative Nanobeacon DOI
Xiaowen Liu, Shuanghong Sun,

Xinchao Xia

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Embryonic development is the beginning of life, and various kinds bioactive molecules are implicated in this crucial process. Especially its early stage, some important biochemical reactions regulating physiological balance may be resuscitated. Thus, revealing dynamic changes during embryonic to elucidation biological phenomena. Peroxynitrite (ONOO-) a typical signaling molecule intercellular communication. However, up now, no work has studied fluctuation ONOO- due low content, especially mammals. Herein, polymeric nanobeacon that integrates an ONOO--responsive degradable scaffold fluorescence amplification module, named IFN, was designed selectively sense with high sensitivity. By virtue specific dye, sensitively detected range 0-4.5 μM detection limit 20.4 nM. From attractive results, sudden increase content after fertilization observed mammalian model, while level decreased slightly at four-cell eight-cell stages, finally reaching equilibrium throughout morula blastocyst stages. This phenomenon resuscitation ovotids, activation life events by fertilization, subsequent establishment balance. not only suggests plays positive role normal but also highlights molecular occurring initial phase life. Furthermore it opens new avenues for monitoring chemical development.

Language: Английский

Citations

0
Recent advances in fluorescent probes for bioimaging lipid droplets associated diseases DOI

Wenli Jiang,

Kexin Du, Jing Zhang

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112792 - 112792

Published: March 1, 2025

Language: Английский

Citations

0
Near-infrared lipid droplet polarity fluorescent probe based on phenothiazine derivative for diagnosis of non-alcoholic fatty liver and tumors DOI

Aobo Sun,

Jiale Li, Jie Wang

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126430 - 126430

Published: May 1, 2025

Language: Английский

Citations

0