Dual-Nanozyme Cascade for System-Wide Specific Colorimetric Detection of Aminoglycoside Antibiotics

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Antibiotic contamination has been a significant concern in environmental monitoring. Nanozyme-based colorimetric sensors can provide valuable support for in-field detection. However, the development of sensing elements capable identifying an entire class specific antibiotics using single material poses considerable challenge. In this work, we present compartmentalized dual-nanozyme cascade composite (Au@mPDA/PAA-Cu2MI, AmPC) designed detection aminoglycoside (AGs), and analyze catalytic mechanisms dual-enzyme system detail. The AmPC possesses both analogue glucose oxidase-like (aGOx-like) peroxidase-like (POD-like) activities. process, AGs with sugar structure serve as initial substrate reaction, while resulting H2O2 acts second Using gentamicin (GMC) proof concept, established range 0.1-10 μg/mL, limit (LOD) 91 ng/mL. addition, validated response other employed principal component analysis (PCA) differentiating among various AGs. This approach enables nanozymes to selectively recognize their targets through mechanism. Furthermore, it facilitates simultaneous identification antibiotics, highlighting its potential applications.

Language: Английский

Defect-Engineered Magnetic Bismuth Nanomedicine for Dual-Modal Imaging and Synergistic Lung Tumor Therapy

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101680 - 101680

Published: March 1, 2025

Language: Английский