Enhancing Clinical Precision in Lung Cancer Tissue Biopsy through Elevated Response-Threshold of an Endoplasmic Reticulum-Targeted Fluorogenic Probe DOI Creative Commons

Zhiyang Yuwen,

Xing‐Long Chen, Kexin Chen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101654 - 101654

Published: March 11, 2025

Lung carcinoma is the leading cause of mortality globally, posing a significant public health concern. Fluorescent-mediated tumor imaging emerging as novel diagnostic and therapeutic approach in clinical practice. Nevertheless, traditional probes lack accuracy diagnosing tumors due to overlap baseline values certain biomarkers between normal cells both exhibit turn-on fluorescence, rendering it impossible distinguish tissue from with high resolution. We introduce sensing strategy that constructs probe an elevated biomarker response-threshold targeting ability for endoplasmic reticulum (ER), enabling precise distinction cells, successfully develop such probe. Elevating advantageous minimizing interference cells. Additionally, ER ensures probe's response range consistent content ER, collectively enhancing differentiation cancer Using this probe, distinct bright fluorescence signal could be observed confocal tissues tumor-bearing mice after intravenous injection, stark contrast limited emanating tissues. Furthermore, demonstrated exceptional precision distinguishing lung para-cancer tissue. This work presents more reliable detection strategy, capable accurate diagnosis even when highly expressed It promises valuable tool future applications, particularly intraoperative assisted resection.

Language: Английский

Enhancing Clinical Precision in Lung Cancer Tissue Biopsy through Elevated Response-Threshold of an Endoplasmic Reticulum-Targeted Fluorogenic Probe DOI Creative Commons

Zhiyang Yuwen,

Xing‐Long Chen, Kexin Chen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101654 - 101654

Published: March 11, 2025

Lung carcinoma is the leading cause of mortality globally, posing a significant public health concern. Fluorescent-mediated tumor imaging emerging as novel diagnostic and therapeutic approach in clinical practice. Nevertheless, traditional probes lack accuracy diagnosing tumors due to overlap baseline values certain biomarkers between normal cells both exhibit turn-on fluorescence, rendering it impossible distinguish tissue from with high resolution. We introduce sensing strategy that constructs probe an elevated biomarker response-threshold targeting ability for endoplasmic reticulum (ER), enabling precise distinction cells, successfully develop such probe. Elevating advantageous minimizing interference cells. Additionally, ER ensures probe's response range consistent content ER, collectively enhancing differentiation cancer Using this probe, distinct bright fluorescence signal could be observed confocal tissues tumor-bearing mice after intravenous injection, stark contrast limited emanating tissues. Furthermore, demonstrated exceptional precision distinguishing lung para-cancer tissue. This work presents more reliable detection strategy, capable accurate diagnosis even when highly expressed It promises valuable tool future applications, particularly intraoperative assisted resection.

Language: Английский

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