Current Analytical Strategies for mRNA-Based Therapeutics
Molecules,
Journal Year:
2025,
Volume and Issue:
30(7), P. 1629 - 1629
Published: April 6, 2025
Recent
advancements
in
mRNA
technology,
utilized
vaccines,
immunotherapies,
protein
replacement
therapies,
and
genome
editing,
have
emerged
as
promising
increasingly
viable
treatments.
The
rapid,
potent,
transient
properties
of
mRNA-encoded
proteins
make
them
attractive
tools
for
the
effective
treatment
a
variety
conditions,
ranging
from
infectious
diseases
to
cancer
single-gene
disorders.
capability
rapid
large-scale
production
therapeutics
fueled
global
response
COVID-19
pandemic.
For
clinical
implementation,
it
is
crucial
deeply
characterize
control
important
attributes
such
purity/integrity,
identity,
structural
quality
features,
functionality.
This
implies
use
powerful
advanced
analytical
techniques
characterization
mRNA.
Improvements
electrophoresis,
chromatography,
mass
spectrometry,
sequencing,
functionality
assessments
significantly
enhanced
detail
information
available
product
process
characterization,
well
routine
stability
release
testing.
Here,
we
review
latest
mRNA-based
therapeutics,
typically
employed
by
biopharmaceutical
industry
eventual
market
release.
Language: Английский
Exploring the potential of oligonucleotide mapping with liquid chromatography – mass spectrometry to study the primary structure of mRNA
TrAC Trends in Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 118309 - 118309
Published: May 1, 2025
Language: Английский